AB229802

Anti-SLC23A2 antibody

Name: Anti-SLC23A2 antibody (ab229802) | Abcam
Brand: Abcam Limited
SKU: AB229802
Price: 490 USD
Availability: InStock
Rating: 3 (1 reviews)

(1 Review)

(5 Publications)

Rabbit Polyclonal SLC23A2 antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC23A2 aa 1-100.

View Alternative Names

KIAA0238, NBTL1, SLC23A1, SVCT2, YSPL2, SLC23A2, Solute carrier family 23 member 2, Na(+)/L-ascorbic acid transporter 2, Nucleobase transporter-like 1 protein, Sodium-dependent vitamin C transporter 2, Yolk sac permease-like molecule 2, hSVCT2

1 Images

Supplier Data

Western blot - Anti-SLC23A2 antibody (AB229802)

All lanes:

Western blot - Anti-SLC23A2 antibody (ab229802) at 1/1000 dilution

Lane 1:

SH-SY5Y (human neuroblastoma cell line from bone marrow) whole cell lysate

Lane 2:

A-375 (human malignant melanoma cell line) whole cell lysate

Secondary

All lanes:

Goat polyclonal to Rabbit IgG at 1/10000 dilution

Predicted band size: 70 kDa

Observed band size: 70 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Recombinant Fragment Protein within Human SLC23A2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q9UGH3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLC23A2 also known as SVCT2 is a sodium-dependent vitamin C transporter with a molecular mass of approximately 71 kDa. This protein functions by facilitating the active transport of vitamin C (ascorbic acid) across cellular membranes using the sodium gradient as a driving force. SLC23A2 is expressed in a variety of tissues prominently in the brain eyes and adrenal glands indicating its significant role in transporting vitamin C to vital organs that are sensitive to oxidative stress.

Biological function summary

SLC23A2 plays a pivotal role in maintaining vitamin C homeostasis within specific tissues. By actively transporting vitamin C into cells it ensures adequate antioxidant protection and collagen synthesis which are essential for tissue repair and immune function. As part of its biological role SLC23A2 does not associate with larger protein complexes but operates as an individual transporter to perform its function effectively.

Pathways

The activity of SLC23A2 is integrated into the ascorbate and aldarate metabolism pathway. It is closely related to the recycling of ascorbate impacting the body's ability to counteract oxidative stress. Additionally SLC23A2 works alongside other transport proteins such as SLC23A1 contributing to overall vitamin C homeostasis and impacting the function of the oxidative stress response pathway.

SLC23A2 has been implicated in conditions linked to vitamin C deficiency and oxidative damage. Disorders such as scurvy and neurodegenerative diseases have shown associations with altered SLC23A2 function. The transporter’s interactions with proteins involved in neuronal health and oxidative stress response suggest its potential involvement in these disorders. Understanding SLC23A2’s role in these conditions could provide therapeutic insights into managing related oxidative stress and tissue integrity issues.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Sodium/ascorbate cotransporter (PubMed : 10471399, PubMed : 10556521). Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (PubMed : 10471399).

See full target information SLC23A2

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

iScience 26:107237 PubMed37485345

2023

Light-responsive microRNA molecules in human retinal organoids are differentially regulated by distinct wavelengths of light.

Applications

Unspecified application

Species

Unspecified reactive species

Canan Celiker,Kamila Weissova,Katerina Amruz Cerna,Jan Oppelt,Birthe Dorgau,Francisco Molina Gambin,Jana Sebestikova,Majlinda Lako,Evelyne Sernagor,Petra Liskova,Tomas Barta

International journal of biological sciences 18:5168-5184 PubMed35982894

2022

Tubule-mitophagic secretion of SerpinG1 reprograms macrophages to instruct anti-septic acute kidney injury efficacy of high-dose ascorbate mediated by NRF2 transactivation.

Applications

Unspecified application

Species

Unspecified reactive species

Yin Ni,Guo-Hua Wu,Juan-Juan Cai,Run Zhang,Yang Zheng,Jing-Quan Liu,Xiang-Hong Yang,Xue Yang,Ye Shen,Jun-Mei Lai,Xiang-Ming Ye,Shi-Jing Mo

Translational oncology 14:101055 PubMed33677235

2021

Ascorbic acid analogue 6-Deoxy-6-[F] fluoro-L-ascorbic acid as a tracer for identifying human colorectal cancer with SVCT2 overexpression.

Applications

Unspecified application

Species

Unspecified reactive species

Peng He,Bing Zhang,Yuan Zou,Yan Zhang,Zhihao Zha,Yali Long,Jia Qiu,Wanqing Shen,Xiaoping Lin,Zhoulei Li,Xiangsong Zhang

Frontiers in pharmacology 11:570939 PubMed33071784

2020

Increased Tumoral Microenvironmental pH Improves Cytotoxic Effect of Pharmacologic Ascorbic Acid in Castration-Resistant Prostate Cancer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Zhoulei Li,Peng He,Ganhua Luo,Xinchong Shi,Gang Yuan,Bing Zhang,Christof Seidl,Andreas Gewies,Yue Wang,Yuan Zou,Yali Long,Dianchao Yue,Xiangsong Zhang

Frontiers in cellular neuroscience 13:429 PubMed31607868

2019

SVCT2 Promotes Neural Stem/Progenitor Cells Migration Through Activating CDC42 After Ischemic Stroke.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Yang,Kaiyuan Zhang,Xuezhu Chen,Ju Wang,Xuejiao Lei,Jun Zhong,Jishu Xian,Yulian Quan,Yongling Lu,Qianying Huang,Jingyu Chen,Hongfei Ge,Hua Feng

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SLC23A2 antibody

Western blot - Anti-SLC23A2 antibody (AB229802)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (5)

Complementary Products

Primary Antibodies

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Product promise