Rabbit Polyclonal SLC24A6 antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human SLC8B1.
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Publications
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- Journal of advanced research 31:35-472021Sleep/wake calcium dynamics, respiratory function, and ROS production in cardiac mitochondria.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEngy A Abdel-Rahman,Salma Hosseiny,Abdullah Aaliya,Mohamed Adel,Basma Yasseen,Abdelrahman Al-Okda,Yasmine Radwan,Saber H Saber,Nada Elkholy,Eslam Elhanafy,Emily E Walker,Juan P Zuniga-Hertz,Hemal H Patel,Helen R Griffiths,Sameh S AliPubMed 34194831
- Nature 586:287-2912020Na controls hypoxic signalling by the mitochondrial respiratory chain.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPablo Hernansanz-Agustín et. al.PubMed 32728214
- Journal of experimental & clinical cancer research 39:1442020IFI6 depletion inhibits esophageal squamous cell carcinoma progression through reactive oxygen species accumulation via mitochondrial dysfunction and endoplasmic reticulum stress.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhenchuan Liu et. al.PubMed 32727517
- Biochimica et biophysica acta. Bioenergetics 1861:1482502020Transport of Ca and Ca-dependent permeability transition in heart mitochondria in the early stages of Duchenne muscular dystrophy.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMikhail V Dubinin et. al.PubMed 32569663
- Nature communications 8:13992017PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress.Applications:Unspecified applicationReactive species:Unspecified reactive speciesEn Huang et. al.PubMed 29123128
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.88% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human SLC8B1. The exact immunogen used to generate this antibody is proprietary information. Database link Q6J4K2
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/1000.00000 | Notes - |
Target data
Function
Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:15060069, PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28130126, PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange (PubMed:15060069, PubMed:28130126). In contrast to other members of the family its function is independent of K(+) (PubMed:15060069).
Alternative names
NCKX6, NCLX, SLC24A6, SLC8B1, Mitochondrial sodium/calcium exchanger protein, Na(+)/K(+)/Ca(2+)-exchange protein 6, Sodium/potassium/calcium exchanger 6, Solute carrier family 24 member 6, Solute carrier family 8 member B1
Recommended products
Rabbit Polyclonal SLC24A6 antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human SLC8B1.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS, 0.88% Sodium chloride- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human SLC8B1. The exact immunogen used to generate this antibody is proprietary information. Database link Q6J4K2
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SLC24A6 also known as the sodium/potassium/calcium exchanger 6 or NCKX6 is a membrane protein involved in the exchange of ions. This protein enables the transport of Na+ Ca2+ and K+ ions across cellular membranes. Its molecular mass is approximately 73 kDa. SLC24A6 is expressed in several tissues particularly in the brain where its function is important for maintaining ion balance within neuronal cells.
- Biological function summary
There are important roles that SLC24A6 plays in cellular homeostasis and signal transduction. As part of a complex network of ion transporters SLC24A6 aids in regulating calcium ion concentration within cells. This regulation is essential for neuronal signaling and overall cellular communication. The ability to exchange ions efficiently allows cells to respond accurately to physiological changes.
- Pathways
SLC24A6 is involved in important signaling cascades such as the calcium signaling pathway and calcineurin signaling pathway. In the calcium signaling pathway it helps modulate intracellular calcium levels which influence various cellular processes like muscle contraction and neurotransmitter release. SLC24A6 also interacts with other ion exchangers and transporters playing a role alongside proteins such as calmodulin which further affect neuronal function.
- Associated diseases and disorders
SLC24A6 has been associated with conditions like bipolar disorder and schizophrenia. Studies suggest that dysfunction in ion homeostasis due to altered SLC24A6 activity can lead to these neurological disorders. Proteins such as DISC1 implicated in multiple mental health conditions are also connected to dysregulation observed in these diseases highlighting the involvement of SLC24A6 within complex genetic and biochemical networks contributing to mental health disorders.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-SLC24A6 antibody (ab136975)
All lanes: Western blot - Anti-SLC24A6 antibody (ab136975) at 1/500 dilution
All lanes: HeLa cell lysate at 30 µg
Predicted band size: 64 kDa
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