Anti-SLC24A6 antibody

Target data

Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed : 15060069, PubMed : 20018762, PubMed : 22829870, PubMed : 23056385, PubMed : 24898248, PubMed : 28130126, PubMed : 28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion : calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion : acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed : 23056385). Required for store-operated Ca(2+) entry (SOCE) and Ca(2+) release-activated Ca(2+) (CRAC) channel regulation : sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed : 28219928). Involved in B-lymphocyte chemotaxis (By similarity). Able to transport Ca(2+) in exchange of either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange (PubMed : 15060069, PubMed : 28130126). In contrast to other members of the family its function is independent of K(+) (PubMed : 15060069).