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Rabbit Polyclonal SLC25A11 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SLC25A11 aa 50-200.

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Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC25A11 antibody (AB272588), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human SLC25A11 aa 50-200. The exact immunogen used to generate this antibody is proprietary information. Database link Q02978

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-P
Human
Tested
Mouse
Predicted
Rat
Predicted
Cow
Predicted

Tested
Tested

Species

Human

Dilution info

1/20.00000 - 1/50.00000

Notes

Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Predicted
Predicted

Species

Mouse, Rat, Cow

Dilution info

-

Notes

-

Target data

Function

Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate. Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity. Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed:21448454). Involved in the regulation of apoptosis (By similarity). Helps protect from cytotoxic-induced apoptosis by modulating glutathione levels in mitochondria (By similarity).

Alternative names

Recommended products

Rabbit Polyclonal SLC25A11 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SLC25A11 aa 50-200.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human SLC25A11 aa 50-200. The exact immunogen used to generate this antibody is proprietary information. Database link Q02978
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The SLC25A11 protein also known as the mitochondrial 2-oxoglutarate/malate carrier protein plays an important role in transporting substrates across the inner mitochondrial membrane. It specifically facilitates the exchange of 2-oxoglutarate and malate between the mitochondria and the cytosol. SLC25A11 has a molecular mass of approximately 33 kDa. Expression of SLC25A11 occurs across various tissues with significant levels in the liver and skeletal muscle where high energy turnover is required.

Biological function summary

SLC25A11 is integral to mitochondrial function and energy metabolism. It is part of a transporter complex involved in the tricarboxylic acid (TCA) cycle supporting the conversion of nutrients into energy. This process is essential for maintaining the cellular energy levels needed for various physiological functions. The efficient transport of 2-oxoglutarate and malate helps in balancing the redox and carbon status in cells contributing to overall cellular homeostasis.

Pathways

SLC25A11 is essential in the TCA cycle and the malate-aspartate shuttle. These pathways are vital for energy production and the regulation of cellular metabolism. In the TCA cycle SLC25A11 works closely with other proteins like isocitrate dehydrogenase participating in the decarboxylation and oxidation processes. In the malate-aspartate shuttle SLC25A11 collaborates with malate dehydrogenase enabling effective NADH transfer into the mitochondria a critical step for ATP generation.

Associated diseases and disorders

SLC25A11 is linked to metabolic and mitochondrial disorders. Mutations or dysfunction in SLC25A11 can contribute to conditions such as mitochondrial diseases where energy production is impaired. This protein also shows associations with some forms of cancer where altered metabolism is a hallmark. Connections with other proteins like fumarate hydratase highlight its role in pathways that when disrupted may lead to disease progression.

Product promise

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1 product image

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC25A11 antibody (ab272588), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC25A11 antibody (ab272588)

    Paraffin-embedded formalin-fixed Human prostate tissue stained for SLC25A11 using ab272588 at 1/50 in immunohistochemical analysis.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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