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AB272588

Anti-SLC25A11 antibody

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Rabbit Polyclonal SLC25A11 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SLC25A11 aa 50-200.

View Alternative Names

SLC20A4, SLC25A11, Mitochondrial 2-oxoglutarate/malate carrier protein, Alpha-oxoglutarate carrier, OGCP, Solute carrier family 25 member 11

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC25A11 antibody (AB272588)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC25A11 antibody (AB272588)

Paraffin-embedded formalin-fixed Human prostate tissue stained for SLC25A11 using ab272588 at 1/50 in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SLC25A11 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.

Q02978

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Proteins & Peptides

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Recombinant Human SLC25A11 protein (GST tag N-Terminus)

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Primary Antibodies

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Primary Antibodies

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZFR antibody (AB272572)

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Primary Antibodies

AB272580

Anti-ZFAND5 antibody

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The SLC25A11 protein also known as the mitochondrial 2-oxoglutarate/malate carrier protein plays an important role in transporting substrates across the inner mitochondrial membrane. It specifically facilitates the exchange of 2-oxoglutarate and malate between the mitochondria and the cytosol. SLC25A11 has a molecular mass of approximately 33 kDa. Expression of SLC25A11 occurs across various tissues with significant levels in the liver and skeletal muscle where high energy turnover is required.
Biological function summary

SLC25A11 is integral to mitochondrial function and energy metabolism. It is part of a transporter complex involved in the tricarboxylic acid (TCA) cycle supporting the conversion of nutrients into energy. This process is essential for maintaining the cellular energy levels needed for various physiological functions. The efficient transport of 2-oxoglutarate and malate helps in balancing the redox and carbon status in cells contributing to overall cellular homeostasis.

Pathways

SLC25A11 is essential in the TCA cycle and the malate-aspartate shuttle. These pathways are vital for energy production and the regulation of cellular metabolism. In the TCA cycle SLC25A11 works closely with other proteins like isocitrate dehydrogenase participating in the decarboxylation and oxidation processes. In the malate-aspartate shuttle SLC25A11 collaborates with malate dehydrogenase enabling effective NADH transfer into the mitochondria a critical step for ATP generation.

SLC25A11 is linked to metabolic and mitochondrial disorders. Mutations or dysfunction in SLC25A11 can contribute to conditions such as mitochondrial diseases where energy production is impaired. This protein also shows associations with some forms of cancer where altered metabolism is a hallmark. Connections with other proteins like fumarate hydratase highlight its role in pathways that when disrupted may lead to disease progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Catalyzes the transport of 2-oxoglutarate (alpha-oxoglutarate) across the inner mitochondrial membrane in an electroneutral exchange for malate (PubMed : 25637873, PubMed : 38937634). Can also exchange 2-oxoglutarate for other dicarboxylic acids such as malonate, succinate, maleate and oxaloacetate, although with lower affinity (By similarity). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (PubMed : 38937634). Does not transport glutathione (PubMed : 25637873). Contributes to several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, gluconeogenesis from lactate, and nitrogen metabolism (By similarity). Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae (PubMed : 21448454). Involved in the regulation of apoptosis (By similarity).
See full target information SLC25A11
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Product promise

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