Anti-SLC29A4/PMAT antibody

Target data

Electrogenic voltage-dependent transporter that mediates the transport of a variety of endogenous bioactive amines, cationic xenobiotics and drugs (PubMed : 15448143, PubMed : 16099839, PubMed : 16873718, PubMed : 17018840, PubMed : 17121826, PubMed : 20592246, PubMed : 20858707, PubMed : 22396231, PubMed : 31537831). Utilizes the physiologic inside-negative membrane potential as a driving force to facilitate cellular uptake of organic cations (PubMed : 15448143, PubMed : 20592246, PubMed : 22396231). Functions as a Na(+)- and Cl(-)-independent bidirectional transporter (PubMed : 15448143, PubMed : 16099839, PubMed : 22396231, PubMed : 31537831). Substrate transport is pH-dependent and enhanced under acidic condition, which is most likely the result of allosteric changes in the transporter structure (PubMed : 16873718, PubMed : 17018840, PubMed : 20592246, PubMed : 22396231, PubMed : 31537831). Implicated in monoamine neurotransmitters uptake such as serotonin, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the central nervous system (PubMed : 15448143, PubMed : 16099839, PubMed : 17018840, PubMed : 17121826, PubMed : 20858707, PubMed : 22396231). Also responsible for the uptake of bioactive amines and drugs through the blood-cerebrospinal fluid (CSF) barrier, from the CSF into choroid plexus epithelial cells, thereby playing a significant role in the clearance of cationic neurotoxins, xenobiotics and metabolic waste in the brain (By similarity). Involved in bidirectional transport of the purine nucleoside adenosine and plays a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia (PubMed : 16873718, PubMed : 20592246, PubMed : 31537831). May be involved in organic cation uptake from the tubular lumen into renal tubular cells, thereby contributing to organic cation reabsorption in the kidney (PubMed : 17018840). Also transports guanidine (PubMed : 16099839).