AB317432
Anti-SLC31A1 / CTR1 antibody [S06-7G0]
- Recombinant
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Rabbit Recombinant Monoclonal SLC31A1 / CTR1 antibody. Suitable for WB and reacts with Human, Rat, Chinese hamster samples. Immunogen corresponding to Synthetic Peptide within Human SLC31A1.
View Alternative Names
COPT1, CTR1, SLC31A1, High affinity copper uptake protein 1, Copper transporter 1, Solute carrier family 31 member 1, hCTR1, Copt1, Ctr1, High affinity copper uptake protein 1, Copper transporter 1, Liver regeneration-related protein LRRGT00200, Solute carrier family 31 member 1, rCTR1
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Reactivity data
{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" }, "Chinese hamster": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }
Product details
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free batch production
For more information, read more on recombinant antibodies.
Properties and storage information
Form
Liquid
Purification technique
Affinity purification
Storage buffer
pH: 7.4 Preservative: 0.01% Sodium azide Constituents: 55.08% Water, 40% Glycerol (glycerin, glycerine), 0.98% Tris glycine, 0.88% Sodium chloride, 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
Product protocols
For this product, it's our understanding that no specific protocols are required. You can visit:
- Visit the General protocols
- Visit the Troubleshooting
Target data
High affinity copper uptake protein 1. Uniporter that mediates the transport of copper(1+) from the extracellular space to the cytoplasm, across the plasma membrane (PubMed : 11734551, PubMed : 16135512, PubMed : 17525160, PubMed : 19740744, PubMed : 20451502, PubMed : 20569931, PubMed : 23658018) and delivers directly copper(1+) to specific chaperone such as ATOX1, via a copper(1+)- mediated transient interaction between the C-terminal domain and a copper(1+) chaperone, thus controlling intracellular copper(1+) levels (PubMed : 11734551, PubMed : 16135512, PubMed : 17525160, PubMed : 19740744, PubMed : 20451502, PubMed : 20569931, PubMed : 23658018, PubMed : 26745413). May function in copper(1+) import from the apical membrane thus may drive intestinal copper absorption (By similarity). The copper(1+) transport mechanism is sodium-independent, saturable and of high-affinity (PubMed : 11734551). Also mediates the uptake of silver(1+) (PubMed : 20569931). May function in the influx of the platinum-containing chemotherapeutic agents (PubMed : 20451502, PubMed : 20569931). The platinum-containing chemotherapeutic agents uptake is saturable (By similarity). In vitro, mediates the transport of cadmium(2+) into cells (PubMed : 33294387). Also participates in the first step of copper(2+) acquisition by cells through a direct transfer of copper(2+) from copper(2+) carriers in blood, such as ALB to the N-terminal domain of SLC31A1, leading to copper(2+) reduction and probably followed by copper(1+) stabilization (PubMed : 30489586). In addition, functions as a redox sensor to promote angiogenesis in endothelial cells, in a copper(1+) transport independent manner, by transmitting the VEGF-induced ROS signal through a sulfenylation at Cys-189 leadin g to a subsequent disulfide bond formation between SLC31A1 and KDR (PubMed : 35027734). The SLC31A1-KDR complex is then co-internalized to early endosomes, driving a sustained VEGFR2 signaling (PubMed : 35027734).. Truncated CTR1 form. Mobilizes copper(1+) out of the endosomal compartment, making copper(1+) available for export out of the cells.
Additional targets
Slc31a1,Slc31a1
Product promise
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