Anti-SLC31A1 / CTR1 Antibody [S06-7G0]

Target data

High affinity copper uptake protein 1. Uniporter that mediates the transport of copper(1+) from the extracellular space to the cytoplasm, across the plasma membrane (PubMed : 11734551, PubMed : 16135512, PubMed : 17525160, PubMed : 19740744, PubMed : 20451502, PubMed : 20569931, PubMed : 23658018) and delivers directly copper(1+) to specific chaperone such as ATOX1, via a copper(1+)- mediated transient interaction between the C-terminal domain and a copper(1+) chaperone, thus controlling intracellular copper(1+) levels (PubMed : 11734551, PubMed : 16135512, PubMed : 17525160, PubMed : 19740744, PubMed : 20451502, PubMed : 20569931, PubMed : 23658018, PubMed : 26745413). May function in copper(1+) import from the apical membrane thus may drive intestinal copper absorption (By similarity). The copper(1+) transport mechanism is sodium-independent, saturable and of high-affinity (PubMed : 11734551). Also mediates the uptake of silver(1+) (PubMed : 20569931). May function in the influx of the platinum-containing chemotherapeutic agents (PubMed : 20451502, PubMed : 20569931). The platinum-containing chemotherapeutic agents uptake is saturable (By similarity). In vitro, mediates the transport of cadmium(2+) into cells (PubMed : 33294387). Also participates in the first step of copper(2+) acquisition by cells through a direct transfer of copper(2+) from copper(2+) carriers in blood, such as ALB to the N-terminal domain of SLC31A1, leading to copper(2+) reduction and probably followed by copper(1+) stabilization (PubMed : 30489586). In addition, functions as a redox sensor to promote angiogenesis in endothelial cells, in a copper(1+) transport independent manner, by transmitting the VEGF-induced ROS signal through a sulfenylation at Cys-189 leadin g to a subsequent disulfide bond formation between SLC31A1 and KDR (PubMed : 35027734). The SLC31A1-KDR complex is then co-internalized to early endosomes, driving a sustained VEGFR2 signaling (PubMed : 35027734).. Truncated CTR1 form. Mobilizes copper(1+) out of the endosomal compartment, making copper(1+) available for export out of the cells.

Additional targets

Slc31a1,Slc31a1