Rabbit Polyclonal SLC40A1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 27 publications. Immunogen corresponding to Synthetic Peptide within Human SLC40A1.
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- Frontiers in endocrinology 13:10488182023PTH 1-34 promoted bone formation by regulating iron metabolism in unloading-induced bone loss.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJingmin Che,Weihao Ren,Xin Chen,Fang Wang,Gejing Zhang,Peng ShangPubMed 36818465
- Frontiers in immunology 13:9855382023Low circulatory Fe and Se levels with a higher IL-6/IL-10 ratio provide nutritional immunity in tuberculosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSandeep R Kaushik,Sukanya Sahu,Hritusree Guha,Sourav Saha,Ranjit Das,Rukuwe-U Kupa,Wetetsho Kapfo,Trinayan Deka,Rumi Basumatary,Asunu Thong,Arunabha Dasgupta,Bidhan Goswami,Amit Kumar Pandey,Lahari Saikia,Vinotsole Khamo,Anjan Das,Ranjan Kumar NandaPubMed 36713405
- Journal of orthopaedic translation 38:126-14020221-2 T static magnetic field combined with Ferumoxytol prevent unloading-induced bone loss by regulating iron metabolism in osteoclastogenesis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGejing Zhang,Chenxiao Zhen,Jiancheng Yang,Zheyuan Zhang,Youde Wu,Jingmin Che,Peng ShangPubMed 36381248
- Redox biology 57:1025092022Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhuo Pei,Yifei Qin,Xianghui Fu,Fengfan Yang,Fei Huo,Xue Liang,Shijie Wang,Hongyong Cui,Peng Lin,Gang Zhou,Jiangna Yan,Jiao Wu,Zhi-Nan Chen,Ping ZhuPubMed 36302319
- Redox report : communications in free radical research 27:119-1272022Norcantharidin down-regulates iron contents in the liver and spleen of lipopolysaccharide-treated mice.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJie Zheng,Jiao-Jiao Wang,Hui-Min Ma,Meng-Qi Shen,Zhong-Ming Qian,Yu-Xin BaoPubMed 35735222
- Nature communications 13:6762022TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJiao Wu,Zhuan Feng,Liang Chen,Yong Li,Huijie Bian,Jiejie Geng,Zhao-Hui Zheng,Xianghui Fu,Zhuo Pei,Yifei Qin,Liu Yang,Yilin Zhao,Ke Wang,Ruo Chen,Qian He,Gang Nan,Xuejun Jiang,Zhi-Nan Chen,Ping ZhuPubMed 35115492
- Biomolecules 12:2021Esophageal Cancer Stem-like Cells Resist Ferroptosis-Induced Cell Death by Active Hsp27-GPX4 Pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChen-Chi Liu,Hsin-Hsien Li,Jiun-Han Lin,Ming-Chen Chiang,Tien-Wei Hsu,Anna Fen-Yau Li,David Hung-Tsang Yen,Han-Shui Hsu,Shih-Chieh HungPubMed 35053196
- Redox biology 46:1021312021Fibroblast growth factor 21 attenuates iron overload-induced liver injury and fibrosis by inhibiting ferroptosis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAimin Wu,Bin Feng,Jie Yu,Lijun Yan,Lianqiang Che,Yong Zhuo,Yuheng Luo,Bing Yu,De Wu,Daiwen ChenPubMed 34530349
- Journal of cellular and molecular medicine 25:5671-56802021The detrimental effect of iron on OA chondrocytes: Importance of pro-inflammatory cytokines induced iron influx and oxidative stress.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXingzhi Jing,Ting Du,Tao Li,Xiaoxia Yang,Guodong Wang,Xiaoyang Liu,Zhensong Jiang,Xingang CuiPubMed 33942503
- Cellular signalling 84:1100242021Iron overload induces apoptosis of osteoblast cells via eliciting ER stress-mediated mitochondrial dysfunction and p-eIF2α/ATF4/CHOP pathway in vitro.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJingmin Che,Huanhuan Lv,Jiancheng Yang,Bin Zhao,Sibo Zhou,Tongyao Yu,Peng ShangPubMed 33901579
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.01% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human SLC40A1. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NP59
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
| Rat | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 20 µg/mL | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
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Target data
Function
Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis (PubMed:15692071, PubMed:22178646, PubMed:22682227, PubMed:24304836, PubMed:29237594, PubMed:29599243, PubMed:30247984). Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (By similarity). When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma (PubMed:22682227, PubMed:29237594, PubMed:32814342).
Alternative names
FPN, FPN1, IREG1, SLC11A3, MSTP079, SLC40A1, Ferroportin, Ferroportin-1, Iron-regulated transporter 1, Solute carrier family 40 member 1
Recommended products
Rabbit Polyclonal SLC40A1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 27 publications. Immunogen corresponding to Synthetic Peptide within Human SLC40A1.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.01% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human SLC40A1. The exact immunogen used to generate this antibody is proprietary information. Database link Q9NP59
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SLC40A1 also known as ferroportin or solute carrier family 40 member 1 is a transmembrane protein which functions as an iron transporter. This protein plays a role in exporting iron from cells into the bloodstream. The molecular weight of SLC40A1 is approximately 62 kDa. It is highly expressed in cells involved in iron storage and metabolism such as enterocytes in the duodenum and macrophages which process senescent red blood cells.
- Biological function summary
The function of this transporter is important for iron homeostasis in human body. SLC40A1 helps balance iron levels by moving iron across intestinal cells into the plasma. It does not function as part of a larger protein complex but its activity is controlled by hepcidin a hormone that degrades SLC40A1 and regulates iron flow into the circulation.
- Pathways
SLC40A1 is essential in the iron homeostasis pathway and the hepcidin regulation pathway. These pathways ensure iron supply matches body demands. It is closely related to hepcidin due to their interactive roles in this regulatory system. Hepcidin binds to SLC40A1 leading to its internalization and degradation which decreases iron export.
- Associated diseases and disorders
Mutations in SLC40A1 can lead to diseases like hemochromatosis characterized by excessive iron accumulation and anemia as iron transport becomes inefficient. Through these conditions SLC40A1 connects to hepcidin where disruption in their interaction contributes to disease pathology. Managing SLC40A1 activity is therefore important for maintaining proper iron levels and preventing related health issues.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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3 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC40A1 antibody (ab78066)
ab78066, at 20μg/ml, staining SLC40A1 in human skeletal muscle by Immunohistochemistry using formalin-fixed, paraffin-embedded tissue.
A heat induced antigen retrieval step was performed using pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC40A1 antibody (ab78066)
Immunohistochemical staining of paraffin embedded, formalin fixed, kidney renal tubular epithelium using ab78066 at 20 μg/mL.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC40A1 antibody (ab78066)
Negative control - immunohistochemical staining of paraffin embedded, formalin fixed, breast epithelium using ab78066 at 20 μg/mL.
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