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AB239583

Anti-SLC40A1 antibody [C2]

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(19 Publications)

Mouse Monoclonal SLC40A1 antibody. Suitable for WB and reacts with Human samples. Cited in 19 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC40A1 aa 100-350.

View Alternative Names

FPN, FPN1, IREG1, SLC11A3, MSTP079, SLC40A1, Ferroportin, Ferroportin-1, Iron-regulated transporter 1, Solute carrier family 40 member 1

1 Images
Western blot - Anti-SLC40A1 antibody [C2] (AB239583)
  • WB

Supplier Data

Western blot - Anti-SLC40A1 antibody [C2] (AB239583)

All lanes:

Western blot - Anti-SLC40A1 antibody [C2] (ab239583) at 5 µg/mL

All lanes:

Recombinant human SLC40A1 protein

Predicted band size: 63 kDa

false

Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

C2

Isotype

IgG2b

Light chain type

kappa

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human SLC40A1 aa 100-350. The exact immunogen used to generate this antibody is proprietary information.

Q9NP59

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A/G
Purification notes
Purified from TCS.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLC40A1 also known as ferroportin or solute carrier family 40 member 1 is a transmembrane protein which functions as an iron transporter. This protein plays a role in exporting iron from cells into the bloodstream. The molecular weight of SLC40A1 is approximately 62 kDa. It is highly expressed in cells involved in iron storage and metabolism such as enterocytes in the duodenum and macrophages which process senescent red blood cells.
Biological function summary

The function of this transporter is important for iron homeostasis in human body. SLC40A1 helps balance iron levels by moving iron across intestinal cells into the plasma. It does not function as part of a larger protein complex but its activity is controlled by hepcidin a hormone that degrades SLC40A1 and regulates iron flow into the circulation.

Pathways

SLC40A1 is essential in the iron homeostasis pathway and the hepcidin regulation pathway. These pathways ensure iron supply matches body demands. It is closely related to hepcidin due to their interactive roles in this regulatory system. Hepcidin binds to SLC40A1 leading to its internalization and degradation which decreases iron export.

Mutations in SLC40A1 can lead to diseases like hemochromatosis characterized by excessive iron accumulation and anemia as iron transport becomes inefficient. Through these conditions SLC40A1 connects to hepcidin where disruption in their interaction contributes to disease pathology. Managing SLC40A1 activity is therefore important for maintaining proper iron levels and preventing related health issues.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis (PubMed : 15692071, PubMed : 22178646, PubMed : 22682227, PubMed : 24304836, PubMed : 29237594, PubMed : 29599243, PubMed : 30247984). Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (By similarity). When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma (PubMed : 22682227, PubMed : 29237594, PubMed : 32814342).
See full target information SLC40A1
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Publications (19)

Recent publications for all applications. Explore the full list and refine your search

Journal of orthopaedic surgery and research 20:835 PubMed40999516

2025

Neuregulin 4 inhibits synovial macrophage pro-inflammatory polarization via ErbB4/Stat5b/NF-κB signaling to alleviate osteoarthritis progression.

Applications

Unspecified application

Species

Unspecified reactive species

Daoliang Jiang,Xiaoli Xu,Wenjing Yang,Mengjia Tang,Yuping Zhang,Lingfeng Shi,Jiongyu Hu

Frontiers in pharmacology 16:1567942 PubMed40535769

2025

Pomolic acid induces ferroptosis-mediated cell death in non-small cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Wenbin Ji,Yanbin Zhang,Wenhao Ji,Hui Zhang,Biao Qin,Xiao-Liang Xing,Zaiqi Zhang

Journal of cellular and molecular medicine 29:e70609 PubMed40394754

2025

Erk1/2 Orchestrates SSPH I-Induced Oxidative Stress, Mitochondrial Dysfunction and Ferroptosis in Hepatocellular Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yuewen Sun,Ying Zhou,Dan Huang,Zhiguang Zhao,Qingrui Shao,Jianzhe Li,Xiaofang Zhao,Xudong Liu

Cell death and differentiation 32:2009-2021 PubMed40369167

2025

ARID1A loss enhances sensitivity to c-MET inhibition by dual targeting of GPX4 and iron homeostasis, inducing ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Xu Zhang,Zihuan Wang,Yilin He,Kejin Wang,Cheng Xiang,Yongfeng Liu,Yijiang Song,Aimin Li,Zhen Wang,Yingnan Yu,Wenxuan Peng,Side Liu,Joong Sup Shim,Changjie Wu

International journal of biological sciences 21:1275-1293 PubMed39897035

2025

Exosomal mediated lipid metabolism, ferritinophagy and CoQ-dependent pathway contributes to the ferroptosis of keratinocyte in SJS/TEN.

Applications

Unspecified application

Species

Unspecified reactive species

Chen Zhang,Pei Qiao,ChunYing Xiao,ZiPeng Cao,JiaoLing Chen,Hui Fang,JianKang Yang,ZeHua Kang,ErLe Dang,Shuai Shao,BingYu Pang,QingYang Li,ZhenLai Zhu,ShengXian Shen,Akito Hasegawa,Riichiro Abe,HongJiang Qiao,Gang Wang,Meng Fu

Heliyon 10:e37477 PubMed39421383

2024

Targeting ferroptosis promotes diabetic wound healing via Nrf2 activation.

Applications

Unspecified application

Species

Unspecified reactive species

Tongcai Wang,Yin Zheng,Jun Zhang,Zhongming Wu

Journal of pharmaceutical analysis 14:86-99 PubMed38352945

2024

Hydralazine represses Fpn ubiquitination to rescue injured neurons via competitive binding to UBA52.

Applications

Unspecified application

Species

Unspecified reactive species

Shengyou Li,Xue Gao,Yi Zheng,Yujie Yang,Jianbo Gao,Dan Geng,Lingli Guo,Teng Ma,Yiming Hao,Bin Wei,Liangliang Huang,Yitao Wei,Bing Xia,Zhuojing Luo,Jinghui Huang

Translational oncology 39:101817 PubMed37939630

2023

Thrombin induces ferroptosis in triple-negative breast cancer through the cPLA2α/ACSL4 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Shuo Xu,Qing-Zhang Tuo,Jie Meng,Xiao-Lei Wu,Chang-Long Li,Peng Lei

Molecules (Basel, Switzerland) 28: PubMed37375197

2023

Terpinen-4-ol Induces Ferroptosis of Glioma Cells via Downregulating JUN Proto-Oncogene.

Applications

Unspecified application

Species

Unspecified reactive species

Wenpeng Cao,Yumei Li,Zhirui Zeng,Shan Lei

Journal of neurochemistry 165:426-444 PubMed36802066

2023

CDGSH iron sulfur domain 2 over-expression alleviates neuronal ferroptosis and brain injury by inhibiting lipid peroxidation via AKT/mTOR pathway following intracerebral hemorrhage in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Ruihao Li,Xingyu Zhang,Lingui Gu,Ye Yuan,Xu Luo,Weiwei Shen,Zongyi Xie
View all publications
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