AB239511

Anti-SLC40A1 antibody [C8]

Name: Anti-SLC40A1 antibody [C8] (ab239511) | Abcam
Brand: Abcam Limited
SKU: AB239511
Price: 525 USD
Availability: InStock

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(14 Publications)

Mouse Monoclonal SLC40A1 antibody. Suitable for WB and reacts with Human samples. Cited in 14 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC40A1 aa 100-350.

View Alternative Names

FPN, FPN1, IREG1, SLC11A3, MSTP079, SLC40A1, Ferroportin, Ferroportin-1, Iron-regulated transporter 1, Solute carrier family 40 member 1

1 Images

Supplier Data

Western blot - Anti-SLC40A1 antibody [C8] (AB239511)

All lanes:

Western blot - Anti-SLC40A1 antibody [C8] (ab239511) at 5 µg/mL

All lanes:

Recombinant human SLC40A1 protein

Predicted band size: 63 kDa

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Key facts

Host species

Mouse

Clonality

Monoclonal

Clone number

Isotype

IgG2b

Light chain type

kappa

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Recombinant Fragment Protein within Human SLC40A1 aa 100-350. The exact immunogen used to generate this antibody is proprietary information.

Q9NP59

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "notRecommended", "WB-species-dilution-info": "0.5-5 µg/mL", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A/G

Purification notes

Purified from TCS.

Storage buffer

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLC40A1 also known as ferroportin or solute carrier family 40 member 1 is a transmembrane protein which functions as an iron transporter. This protein plays a role in exporting iron from cells into the bloodstream. The molecular weight of SLC40A1 is approximately 62 kDa. It is highly expressed in cells involved in iron storage and metabolism such as enterocytes in the duodenum and macrophages which process senescent red blood cells.

Biological function summary

The function of this transporter is important for iron homeostasis in human body. SLC40A1 helps balance iron levels by moving iron across intestinal cells into the plasma. It does not function as part of a larger protein complex but its activity is controlled by hepcidin a hormone that degrades SLC40A1 and regulates iron flow into the circulation.

Pathways

SLC40A1 is essential in the iron homeostasis pathway and the hepcidin regulation pathway. These pathways ensure iron supply matches body demands. It is closely related to hepcidin due to their interactive roles in this regulatory system. Hepcidin binds to SLC40A1 leading to its internalization and degradation which decreases iron export.

Mutations in SLC40A1 can lead to diseases like hemochromatosis characterized by excessive iron accumulation and anemia as iron transport becomes inefficient. Through these conditions SLC40A1 connects to hepcidin where disruption in their interaction contributes to disease pathology. Managing SLC40A1 activity is therefore important for maintaining proper iron levels and preventing related health issues.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis (PubMed : 15692071, PubMed : 22178646, PubMed : 22682227, PubMed : 24304836, PubMed : 29237594, PubMed : 29599243, PubMed : 30247984). Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (By similarity). When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma (PubMed : 22682227, PubMed : 29237594, PubMed : 32814342).

See full target information SLC40A1

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Publications (14)

Recent publications for all applications. Explore the full list and refine your search

American journal of cancer research 15:3434-3448 PubMed40948531

2025

Differentiating early-stage nasopharyngeal carcinoma from adenoidal hypertrophy via SLC40A1 expression and developing a prognostic model for disease progression.

Applications

Unspecified application

Species

Unspecified reactive species

Hongwei Wang,Suqing Qi,Chaobing Liu,Zhenhua Qiao,Chao Zhang

World journal of gastrointestinal oncology 17:104522 PubMed40487942

2025

Simvastatin inhibits proliferation and migration, promotes oxidative stress and ferroptosis in colon cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Liu,Hao Ge,Zhi-Min Fan,Ting Lu,Lei He,Meng Li,Hao-Ran Zhao,Qiang Leng

Journal of molecular neuroscience : MN 75:63 PubMed40317390

2025

Electroacupuncture Inhibits Ferroptosis by Modulating Iron Metabolism and Oxidative Stress to Alleviate Cerebral Ischemia-Reperfusion Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Yaoyao Liu,Qi Wang,Ziwen Hou,Ying Gao,Peng Li

Molecular medicine reports 31: PubMed40183404

2025

α‑ketoglutarate protects against septic cardiomyopathy by improving mitochondrial mitophagy and fission.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Wu,Qiong Ma,Bo-Tao Li,Shuang Shi,Gong-Chang Guan,Jun-Kui Wang,Bao-Yao Xue,Zhong-Wei Liu

Frontiers in pharmacology 15:1503064 PubMed39619616

2024

Tetramethylpyrazine inhibits ferroptosis in spinal cord injury by regulating iron metabolism through the NRF2/ARE pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jingwei Tao,Jingya Zhou,Hanjie Zhu,Lin Xu,Jizhou Yang,Xiaohong Mu,Xiao Fan

Heliyon 10:e33675 PubMed39071725

2024

Acupuncture improve proteinuria in diabetic kidney disease rats by inhibiting ferroptosis and epithelial-mesenchymal transition.

Applications

Unspecified application

Species

Unspecified reactive species

J I Yue,Z H A N G Xin-Yuan,X I A O Yun-Ming,Z H U A N G Zi-Hao,Y A N G Xiao-Hui,L I Xin-Ju

Environmental science and pollution research international 30:111051-111061 PubMed37801247

2023

PM 2.5 juvenile exposure-induced spermatogenesis dysfunction by triggering testes ferroptosis and antioxidative vitamins intervention in adult male rats.

Applications

Unspecified application

Species

Unspecified reactive species

Xiang Liu,Yaya Ai,Mingchen Xiao,Cao Wang,Zhen Shu,Jia Yin,Yu Chu,Qing Xiao,Bin Liu

Redox biology 62:102708 PubMed37116254

2023

17β-oestradiol inhibits ferroptosis in the hippocampus by upregulating DHODH and further improves memory decline after ovariectomy.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Tian,Yuan Xie,Zaixin Guo,Penghui Feng,Yang You,Qi Yu

Neurochemical research 48:2542-2551 PubMed37061657

2023

Dithiolethiones D3T and ACDT Protect Against Iron Overload-Induced Cytotoxicity and Serve as Ferroptosis Inhibitors in U-87 MG Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Neha Kulkarni,Rajitha Gadde,Swati Betharia

Cancer cell international 23:5 PubMed36639654

2023

Heat shock protein 27 deficiency promotes ferrous ion absorption and enhances acyl-Coenzyme A synthetase long-chain family member 4 stability to promote glioblastoma cell ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Kai Zhang,Yue Wu,Guangliang Chen,Hao Wang,Yongsheng Liu,Youxin Zhou

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-SLC40A1 antibody [C8]

Western blot - Anti-SLC40A1 antibody [C8] (AB239511)

Key facts

Host species

Clonality

Clone number

Isotype

Light chain type

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (14)

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