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AB254754

Anti-SLC41A1 antibody

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(1 Publication)

Rabbit Polyclonal SLC41A1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC41A1 aa 350-450.

View Alternative Names

Solute carrier family 41 member 1, SLC41A1

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC41A1 antibody (AB254754)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC41A1 antibody (AB254754)

Paraffin-embedded human heart muscle tissue stained for SLC41A1 using ab254754 at 1/50 dilution in immunohistochemical analysis.

Western blot - Anti-SLC41A1 antibody (AB254754)
  • WB

Supplier Data

Western blot - Anti-SLC41A1 antibody (AB254754)

All lanes:

Western blot - Anti-SLC41A1 antibody (ab254754) at 0.4 µg/mL

All lanes:

RT4 (Human urinary bladder cancer cell line) whole cell lysate

Predicted band size: 55 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human SLC41A1 aa 350-450. The exact immunogen used to generate this antibody is proprietary information.

Q8IVJ1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLC41A1 also known as Solute Carrier Family 41 Member 1 functions mechanically as a magnesium transporter. It plays a role in the cellular transport of magnesium ions across membranes. This transporter protein has an approximate molecular mass of 51 kDa. Expression of SLC41A1 occurs in various tissues but shows higher levels in heart muscle and the kidneys indicating its significant relevance in these areas.
Biological function summary

SLC41A1 contributes to maintaining intracellular magnesium homeostasis. It forms part of a larger magnesium ion transport system that helps cells regulate vital activities such as enzyme activation and nucleic acid stability. The proper function of SLC41A1 ensures magnesium's availability for biochemical reactions highlighting the importance of its regulation within cellular environments.

Pathways

SLC41A1 plays a role in magnesium-related transport and homeostasis pathways. It interacts with other proteins involved in magnesium handling such as CNNM2 and TRPM7 to maintain proper magnesium levels within the cell. These pathways are critical for maintaining cellular equilibrium and ensuring that magnesium-dependent processes proceed efficiently.

Abnormalities in SLC41A1 function link to conditions like hypomagnesemia and Parkinson's disease. Mutations or dysregulation of this transporter can disrupt magnesium levels contributing to neurological and metabolic disturbances. Studies also suggest connections between SLC41A1 and proteins such as MPP family proteins in the pathogenesis of Parkinson's disease.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Na(+)/Mg(2+) ion exchanger that acts as a predominant Mg(2+) efflux system at the plasma membrane (PubMed : 18367447, PubMed : 22031603, PubMed : 23661805, PubMed : 23976986). Transporter activity is driven by the inwardly directed electrochemical gradient for Na(+) ions, thus directly depends on the extracellular Na(+) ion concentration set by Na(+)/K(+) pump (PubMed : 22031603, PubMed : 23661805). Generates circadian cellular Mg(2+) fluxes that feed back to regulate clock-controlled gene expression and metabolism and facilitate higher energetic demands during the day (PubMed : 27074515). Has a role in regulating the activity of ATP-dependent enzymes, including those operating in Krebs cycle and the electron transport chain (By similarity).
See full target information SLC41A1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of medical sciences 21:3069-3082 PubMed39628683

2024

SLC41A1 overexpression correlates with immune cell infiltration in HCC and promotes its malignant progression.

Applications

Unspecified application

Species

Unspecified reactive species

Gang Chen,Zhipeng Du,Caijun Rao
View all publications
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Product promise

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