AB110767

Anti-SLC44A1/CTL1 antibody

Name: Anti-SLC44A1/CTL1 antibody (ab110767) | Abcam
Brand: Abcam Limited
SKU: AB110767

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(13 Publications )

Rabbit Polyclonal SLC44A1/CTL1 antibody. Suitable for WB and reacts with Human samples. Cited in 13 publications.

1 Images

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Western blot - Anti-SLC44A1/CTL1 antibody (AB110767)

All lanes:

Western blot - Anti-SLC44A1/CTL1 antibody (ab110767) at 1/500 dilution

Lane 1:

Extracts from K562 cells at 30 µg

Lane 2:

Extracts from K562 cells at 30 µg with immunising peptide

Predicted band size: 73 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA, 0.88% Sodium chloride

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Storage information

Stable for 12 months at -20°C

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The target SLC44A1 also known as CTL1 is a member of the choline transporter-like family. This protein is essential for transporting choline across cell membranes. As a membrane protein it is involved in the uptake of choline a necessary precursor for the synthesis of phosphatidylcholine and acetylcholine. CTL1 has a molecular mass of approximately 70 kDa. It is expressed in various tissues including the brain liver and kidneys highlighting its importance across multiple biological systems.

Biological function summary

SLC44A1 plays a significant role in the synthesis of membrane phospholipids. It does not act alone; it forms part of a complex system involving other transporter proteins to ensure efficient choline uptake and utilization. By facilitating choline transport CTL1 supports the production of important lipids for cell membrane integrity and neurotransmission contributing to processes important for cellular communication and function.

Pathways

SLC44A1 impacts significant metabolic pathways such as the Kennedy pathway responsible for phosphatidylcholine biosynthesis. Its activity is closely associated with enzymes like choline kinase and phosphocholine cytidylyltransferase which further facilitate phospholipid biosynthesis. This pathway integration highlights its role in maintaining membrane structure and signaling functions.

SLC44A1 has implications in neurological conditions such as Alzheimer’s disease and certain types of cancer. In Alzheimer's impaired choline transport can lead to deficits in acetylcholine a neurotransmitter necessary for memory and learning. Moreover aberrant expression of CTL1 is linked with oncogenic processes in liver cancer. In these cases its interaction with proteins associated with choline metabolism and cellular growth indicates potential mechanisms underlying disease pathogenesis.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Choline/H+ antiporter (PubMed : 19357133, PubMed : 23651124, PubMed : 31855247, PubMed : 33789160). Also acts as a high-affinity ethanolamine/H+ antiporter, regulating the supply of extracellular ethanolamine (Etn) for the CDP-Etn pathway, redistribute intracellular Etn and balance the CDP-Cho and CDP-Etn arms of the Kennedy pathway (PubMed : 33789160). Involved in membrane synthesis and myelin production (PubMed : 31855247).

See full target information SLC44A1

Alternative Names

CD92, CDW92, CTL1, SLC44A1, Choline transporter-like protein 1, CDw92, Solute carrier family 44 member 1

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Publications (13)

Recent publications for all applications. Explore the full listand refine your search

Scientific reports 15:31927 PubMed40883446

2025

Choline transporter-like protein 1 in tongue squamous cell carcinoma: implications for cell proliferation and differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Nao Hashimoto,Kei Nakajima,Yoshihiko Akashi,Katsutoshi Kokubun,Keisuke Sugahara,Akira Katakura,Kenichi Matsuzaka

Discover oncology 16:640 PubMed40301147

2025

LINC00704 facilitates cell proliferation, migration, and invasion via miR-323a-3p/SLC44A1 axis in epithelial ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaojuan Kong,Lei Lei,Zhengjiao Ma

International journal of molecular sciences 23: PubMed36012189

2022

Functional Expression of Choline Transporters in Microglia and Their Regulation of Microglial M1/M2 Polarization.

Applications

Unspecified application

Species

Unspecified reactive species

Toshio Okada,Eisuke Muto,Tsuyoshi Yamanaka,Hiroyuki Uchino,Masato Inazu

Cardiovascular therapeutics 2022:9966306 PubMed35360546

2022

Upregulated miR-206 Aggravates Deep Vein Thrombosis by Regulating GJA1-Mediated Autophagy of Endothelial Progenitor Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Li,Jingping Ge,Yuanyuan Yin,Ruowen Yang,Jie Kong,Jianping Gu

Pharmaceutics 14: PubMed35214160

2022

Anticancer Activity of the Choline Kinase Inhibitor PL48 Is Due to Selective Disruption of Choline Metabolism and Transport Systems in Cancer Cell Lines.

Applications

Unspecified application

Species

Unspecified reactive species

Pablo García-Molina,Alberto Sola-Leyva,Pilar M Luque-Navarro,Alejandro Laso,Pablo Ríos-Marco,Antonio Ríos,Daniela Lanari,Archimede Torretta,Emilio Parisini,Luisa C López-Cara,Carmen Marco,María P Carrasco-Jiménez

Cells 10: PubMed33672580

2021

Functional Expression of Choline Transporters in Human Neural Stem Cells and Its Link to Cell Proliferation, Cell Viability, and Neurite Outgrowth.

Applications

Unspecified application

Species

Unspecified reactive species

Yosuke Fujita,Tomoki Nagakura,Hiroyuki Uchino,Masato Inazu,Tsuyoshi Yamanaka

International journal of molecular sciences 21: PubMed32707889

2020

Molecular and Functional Analysis of Choline Transporters and Antitumor Effects of Choline Transporter-Like Protein 1 Inhibitors in Human Pancreatic Cancer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Kaho Hirai,Saiichiro Watanabe,Nozomi Nishijima,Kaoru Shibata,Akane Hase,Tsuyoshi Yamanaka,Masato Inazu

Molecular medicine reports 21:777-785 PubMed31974614

2020

Protein kinase C promotes choline transporter‑like protein 1 function via improved cell surface expression in immortalized human hepatic cells.

Applications

Unspecified application

Species

Unspecified reactive species

Takuya Ishikawa,Hirotsugu Suwanai,Junpei Shikuma,Ryo Suzuki,Tsuyoshi Yamanaka,Masato Odawara,Masato Inazu

Biomolecules & therapeutics 28:195-201 PubMed31693854

2019

Functional Expression of Choline Transporter-Like Protein 1 in LNCaP Prostate Cancer Cells: A Novel Molecular Target.

Applications

Unspecified application

Species

Unspecified reactive species

Iwao Saiki,Miki Yara,Tsuyoshi Yamanaka,Hiroyuki Uchino,Masato Inazu

Evidence-based complementary and alternative medic 2019:1282085 PubMed31772590

2019

Tuina Massage Improves Cognitive Functions of Hypoxic-Ischemic Neonatal Rats by Regulating Genome-Wide DNA Hydroxymethylation Levels.

Applications

Unspecified application

Species

Unspecified reactive species

Yunpeng Zhang,Chao Gao,Danmei Chen,Cuiting Wang,Long Chen,Yaodong Zhang,Bing Li

View all publications

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Product promise

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Anti-SLC44A1/CTL1 antibody

Western blot - Anti-SLC44A1/CTL1 antibody (AB110767)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Alternative Names

Publications (13)

Product promise