Anti-SLC44A2 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

SLC44A2 also known as choline transporter-like protein 2 (CTL2) is a membrane protein involved in the transport of choline and other organic cations. It has a molecular mass of approximately 80 kDa. Researchers have identified its expression in diverse tissues including the inner ear kidney and immune cells like monocytes neutrophils and dendritic cells.

Biological function summary

SLC44A2 contributes to cellular choline uptake which is important for synthesizing phosphatidylcholine a major phospholipid in cell membranes. It plays a role in hearing and immune response. This protein is part of the solute carrier family and works alongside other transporters to ensure adequate levels of choline in the cellular environment.

Pathways

Researchers have linked SLC44A2 to the phospholipid biosynthesis pathway and the acetylcholine synthesis pathway. It is important for ensuring cell membrane integrity and cellular communication. The choline transporter activity of SLC44A2 connects it with pathways involving other proteins like choline kinase and acetyl-CoA which are essential for synthesizing structural and signaling molecules in cells.

Associated diseases and disorders

SLC44A2 associates with autoimmune inner ear disease and thrombotic disorders. Variants in SLC44A2 may affect auditory function implicating them in hereditary hearing loss. In the context of thrombotic disorders SLC44A2's expression on neutrophils connects it to mechanisms involving proteins like tissue factor contributing to blood coagulation processes and potential clot formation.