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AB133722

Anti-SLC44A2 antibody

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(1 Publication)

Rabbit Polyclonal SLC44A2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SLC44A2 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

CTL2, PSEC0210, SLC44A2, Choline transporter-like protein 2, Solute carrier family 44 member 2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC44A2 antibody (AB133722)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC44A2 antibody (AB133722)

Immunohistochemical analysis of formalin-fixed, paraffin embedded Human kidney tissue labelling SLC44A2 with ab133722 at 10μg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC44A2 antibody (AB133722)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC44A2 antibody (AB133722)

Immunohistochemical analysis of formalin-fixed, paraffin embedded Human prostate tissue labelling SLC44A2 with ab133722 at 10 μg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human SLC44A2 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q8IWA5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-80°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLC44A2 also known as choline transporter-like protein 2 (CTL2) is a membrane protein involved in the transport of choline and other organic cations. It has a molecular mass of approximately 80 kDa. Researchers have identified its expression in diverse tissues including the inner ear kidney and immune cells like monocytes neutrophils and dendritic cells.
Biological function summary

SLC44A2 contributes to cellular choline uptake which is important for synthesizing phosphatidylcholine a major phospholipid in cell membranes. It plays a role in hearing and immune response. This protein is part of the solute carrier family and works alongside other transporters to ensure adequate levels of choline in the cellular environment.

Pathways

Researchers have linked SLC44A2 to the phospholipid biosynthesis pathway and the acetylcholine synthesis pathway. It is important for ensuring cell membrane integrity and cellular communication. The choline transporter activity of SLC44A2 connects it with pathways involving other proteins like choline kinase and acetyl-CoA which are essential for synthesizing structural and signaling molecules in cells.

SLC44A2 associates with autoimmune inner ear disease and thrombotic disorders. Variants in SLC44A2 may affect auditory function implicating them in hereditary hearing loss. In the context of thrombotic disorders SLC44A2's expression on neutrophils connects it to mechanisms involving proteins like tissue factor contributing to blood coagulation processes and potential clot formation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Isoform 1. Choline/H+ antiporter, mainly in mitochondria (PubMed : 10677542, PubMed : 20665236, PubMed : 23651124, PubMed : 33789160). Also acts as a low-affinity ethanolamine/H+ antiporter, regulating the supply of extracellular ethanolamine (Etn) for the CDP-Etn pathway, redistribute intracellular Etn and balance the CDP-Cho and CDP-Etn arms of the Kennedy pathway (PubMed : 33789160).. Isoform 3. Does not exhibit choline transporter activity.
See full target information SLC44A2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of inflammation research 17:7261-7274 PubMed39429850

2024

Activating Transcription Factor 6 Mediates Inflammation in Experimental Varicocele-Induced Epididymal Epithelial Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yin-Shan Jin,Yuan-Qing Cui,Yan-Ping Xu,Jie Chen,Xue-Bao Zhang,Xiong Wang
View all publications
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Product promise

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