Skip to main content

Rabbit Polyclonal SLC44A2 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human SLC44A2 conjugated to Keyhole Limpet Haemocyanin.

Be the first to review this product! Submit a review

Images

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.4
Preservative: 0.1% Sodium azide
Constituents: 99% PBS

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Synthetic Peptide within Human SLC44A2 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q8IWA5
Loading...
Loading...
Loading...
Loading...
Loading...
Loading...
Loading...
Loading...

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-P
Human
Tested

Tested
Tested

Species

Human

Dilution info

10 µg/mL

Notes

Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target data

Function

Isoform 1, but not isoform 3, exhibits some choline transporter activity.

Alternative names

Recommended products

  1. Loading...
  2. Loading...
  3. Loading...
  4. Loading...

Rabbit Polyclonal SLC44A2 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human SLC44A2 conjugated to Keyhole Limpet Haemocyanin.

Alternative names

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Synthetic Peptide within Human SLC44A2 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information. Database link Q8IWA5
Purification technique

Affinity purification Immunogen

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate long-term storage conditions

-80°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

Biological function summary

SLC44A2 contributes to cellular choline uptake which is important for synthesizing phosphatidylcholine a major phospholipid in cell membranes. It plays a role in hearing and immune response. This protein is part of the solute carrier family and works alongside other transporters to ensure adequate levels of choline in the cellular environment.

Activity summary

SLC44A2 also known as choline transporter-like protein 2 (CTL2) is a membrane protein involved in the transport of choline and other organic cations. It has a molecular mass of approximately 80 kDa. Researchers have identified its expression in diverse tissues including the inner ear kidney and immune cells like monocytes neutrophils and dendritic cells.

Pathways

Researchers have linked SLC44A2 to the phospholipid biosynthesis pathway and the acetylcholine synthesis pathway. It is important for ensuring cell membrane integrity and cellular communication. The choline transporter activity of SLC44A2 connects it with pathways involving other proteins like choline kinase and acetyl-CoA which are essential for synthesizing structural and signaling molecules in cells.

Associated diseases and disorders

SLC44A2 associates with autoimmune inner ear disease and thrombotic disorders. Variants in SLC44A2 may affect auditory function implicating them in hereditary hearing loss. In the context of thrombotic disorders SLC44A2's expression on neutrophils connects it to mechanisms involving proteins like tissue factor contributing to blood coagulation processes and potential clot formation.

Product promise

We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

In the unlikely event of one of our products not working as expected, you are covered by our product promise.

Full details and terms and conditions can be found here:
Terms & Conditions.

2 product images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC44A2 antibody (ab133722), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC44A2 antibody (ab133722)

    Immunohistochemical analysis of formalin-fixed, paraffin embedded Human prostate tissue labelling SLC44A2 with ab133722 at 10 μg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC44A2 antibody (ab133722), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC44A2 antibody (ab133722)

    Immunohistochemical analysis of formalin-fixed, paraffin embedded Human kidney tissue labelling SLC44A2 with ab133722 at 10μg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Downloads

Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

There was a problem

We can’t download that datasheet. Please try again. If you need help, contact our Customer Services team at technical@abcam.com