Rabbit Polyclonal SLC44A4 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SLC44A4 aa 50-200.
Images
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human SLC44A4 aa 50-200. The exact immunogen used to generate this antibody is proprietary information. Database link Q53GD3
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/20.00000 - 1/50.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target data
Function
Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity) (PubMed:23651124, PubMed:28013291). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis (PubMed:24379411, PubMed:26741288). Isoform 3. Has also thiamine pyrophosphate transporter activity.
Alternative names
C6orf29, CTL4, NG22, TPPT1, UNQ441/PRO874, SLC44A4, Choline transporter-like protein 4, Solute carrier family 44 member 4, Thiamine pyrophosphate transporter 1, hTPPT1
Recommended products
Rabbit Polyclonal SLC44A4 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SLC44A4 aa 50-200.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human SLC44A4 aa 50-200. The exact immunogen used to generate this antibody is proprietary information. Database link Q53GD3
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SLC44A4 also known as a choline transporter-like protein functions primarily as a sodium-independent choline transporter. This protein helps in transporting choline across membranes which is essential for phospholipid synthesis and acetylcholine production. SLC44A4 has an approximate mass of 82 kDa. The expression of SLC44A4 is most notable in the epithelial cells of the colon and small intestine where it plays a significant role in maintaining choline homeostasis.
- Biological function summary
SLC44A4 plays a role in maintaining cellular choline levels and contributes to phospholipids and cell membrane biosynthesis. It is part of a broader group that facilitates choline transport across cellular membranes. While it functions independently its activity has implications for cellular membrane integrity and signaling. Choline being a precursor for acetylcholine indicates that SLC44A4 has a potential indirect role in neurotransmission although primarily emphasized in epithelial tissues.
- Pathways
SLC44A4 links to phosphatidylcholine biosynthesis and the Kennedy pathway both critical for cell membrane formation and maintenance. Within these pathways SLC44A4 functions alongside key enzymes such as choline kinase and CTP: phosphocholine cytidylyltransferase. These enzymes and SLC44A4 work together to ensure the effective supply of choline for membrane phospholipid synthesis indicating an integrated role in cellular membrane processes.
- Associated diseases and disorders
Altered expression or function of SLC44A4 has been associated with certain gastrointestinal disorders including inflammatory bowel disease (IBD). This is due to its critical role in epithelial integrity and function. Furthermore dysfunction in choline transport mechanisms implicates SLC44A4 in cognitive disorders given the importance of choline in neurotransmitter synthesis. The protein's potential interaction with enzymes like choline kinase amplifies this connection as it further influences choline's availability for acetylcholine synthesis in neural tissues even though these effects are more pronounced in intestinal contexts.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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3 product images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC44A4 antibody (ab188308)
Immunohistochemical analysis of paraffin-embedded Human fallopian tube tissue tissue labeling SLC44A4 with ab188308 at 1/20 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC44A4 antibody (ab188308)
Immunohistochemical analysis of paraffin-embedded Human prostate tissue tissue labeling SLC44A4 with ab188308 at 1/20 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC44A4 antibody (ab188308)
Immunohistochemical analysis of paraffin-embedded Human duodenum tissue tissue labeling SLC44A4 with ab188308 at 1/20 dilution.
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