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AB188308

Anti-SLC44A4 antibody

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Rabbit Polyclonal SLC44A4 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SLC44A4 aa 50-200.

View Alternative Names

C6orf29, CTL4, NG22, TPPT1, UNQ441/PRO874, SLC44A4, Choline transporter-like protein 4, Solute carrier family 44 member 4, Thiamine pyrophosphate transporter 1, hTPPT1

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC44A4 antibody (AB188308)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC44A4 antibody (AB188308)

Immunohistochemical analysis of paraffin-embedded Human prostate tissue tissue labeling SLC44A4 with ab188308 at 1/20 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC44A4 antibody (AB188308)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC44A4 antibody (AB188308)

Immunohistochemical analysis of paraffin-embedded Human fallopian tube tissue tissue labeling SLC44A4 with ab188308 at 1/20 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC44A4 antibody (AB188308)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC44A4 antibody (AB188308)

Immunohistochemical analysis of paraffin-embedded Human duodenum tissue tissue labeling SLC44A4 with ab188308 at 1/20 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SLC44A4 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.

Q53GD3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLC44A4 also known as a choline transporter-like protein functions primarily as a sodium-independent choline transporter. This protein helps in transporting choline across membranes which is essential for phospholipid synthesis and acetylcholine production. SLC44A4 has an approximate mass of 82 kDa. The expression of SLC44A4 is most notable in the epithelial cells of the colon and small intestine where it plays a significant role in maintaining choline homeostasis.
Biological function summary

SLC44A4 plays a role in maintaining cellular choline levels and contributes to phospholipids and cell membrane biosynthesis. It is part of a broader group that facilitates choline transport across cellular membranes. While it functions independently its activity has implications for cellular membrane integrity and signaling. Choline being a precursor for acetylcholine indicates that SLC44A4 has a potential indirect role in neurotransmission although primarily emphasized in epithelial tissues.

Pathways

SLC44A4 links to phosphatidylcholine biosynthesis and the Kennedy pathway both critical for cell membrane formation and maintenance. Within these pathways SLC44A4 functions alongside key enzymes such as choline kinase and CTP: phosphocholine cytidylyltransferase. These enzymes and SLC44A4 work together to ensure the effective supply of choline for membrane phospholipid synthesis indicating an integrated role in cellular membrane processes.

Altered expression or function of SLC44A4 has been associated with certain gastrointestinal disorders including inflammatory bowel disease (IBD). This is due to its critical role in epithelial integrity and function. Furthermore dysfunction in choline transport mechanisms implicates SLC44A4 in cognitive disorders given the importance of choline in neurotransmitter synthesis. The protein's potential interaction with enzymes like choline kinase amplifies this connection as it further influences choline's availability for acetylcholine synthesis in neural tissues even though these effects are more pronounced in intestinal contexts.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Choline transporter that plays a role in the choline-acetylcholine system and is required to the efferent innervation of hair cells in the olivocochlear bundle for the maintenance of physiological function of outer hair cells and the protection of hair cells from acoustic injury (By similarity) (PubMed : 23651124, PubMed : 28013291). Also described as a thiamine pyrophosphate transporter in colon, may mediate the absorption of microbiota-generated thiamine pyrophosphate and contribute to host thiamine (vitamin B1) homeostasis (PubMed : 24379411, PubMed : 26741288).. Isoform 3. Also has thiamine pyrophosphate transporter activity.
See full target information SLC44A4
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Product promise

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