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AB75332

Anti-SLC45A2 antibody

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(1 Publication)

Rabbit Polyclonal SLC45A2 antibody. Suitable for WB, IF, ELISA and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SLC45A2.

View Alternative Names

AIM1, MATP, SLC45A2, Membrane-associated transporter protein, Melanoma antigen AIM1, Solute carrier family 45 member 2, Protein AIM-1

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ELISA, WB, IF

applications

Immunogen

Synthetic Peptide within Human SLC45A2. The exact immunogen used to generate this antibody is proprietary information.

Q9UMX9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IF" : {"fullname" : "Immunofluorescence", "shortname":"IF"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/200 - 1/2000", "WB-species-notes": "<p></p>", "IF-species-checked": "guaranteed", "IF-species-dilution-info": "1/50 - 1/500", "IF-species-notes": "<p></p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IF-species-checked": "predicted", "IF-species-dilution-info": "", "IF-species-notes": "", "ELISA-species-checked": "predicted", "ELISA-species-dilution-info": "", "ELISA-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLC45A2 also known as the membrane-associated transporter protein (MATP) is an integral membrane protein with a mass of approximately 67 kDa. It functions mechanically by transporting molecules across cell membranes specifically facilitating the transport of melanin-related compounds in melanocytes which are pigment cells in the skin. SLC45A2 is expressed notably in the skin eyes and hair follicles aligning its function with pigmentation processes.
Biological function summary

SLC45A2 plays a critical role in melanin synthesis within the melanosomes the organelles where melanin is produced and stored. It is responsible for regulating pH levels and ion balance within these organelles helping control the environment necessary for the function of tyrosinase an important enzyme in melanin production. Although not part of a complex SLC45A2's activity is integral to maintaining proper melanocyte health and function in the skin.

Pathways

SLC45A2 is essential in the melanin biosynthesis pathway where it influences tyrosinase activity by affecting melanosomal pH. This interaction aids in the conversion of tyrosine to melanin which is a major process in pigmentation. Additionally SLC45A2 associates with the MC1R signaling pathway which regulates melanocyte response to external signals highlighting the interconnected nature of pigment production mechanisms in the body.

Defects in SLC45A2 are linked to oculocutaneous albinism type 4 (OCA4) a condition characterized by reduced melanin production in the skin hair and eyes leading to lighter pigmentation and vision problems. The target also has relevance in melanoma a form of skin cancer where abnormal melanocyte function drives uncontrolled cell growth. Here SLC45A2 can potentially interact with proteins like MITF a transcription factor that regulates melanocyte activity and survival impacting the progression of pigmentation-related diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Proton-associated glucose and sucrose transporter (By similarity). May be able to transport also fructose (By similarity). Expressed at a late melanosome maturation stage where functions as proton/glucose exporter which increase lumenal pH by decreasing glycolysis (PubMed : 32966160, PubMed : 35469906). Regulates melanogenesis by maintaining melanosome neutralization that is initially initiated by transient OCA2 and required for a proper function of the tyrosinase TYR (PubMed : 32966160, PubMed : 35469906).
See full target information SLC45A2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

EBioMedicine 48:264-276 PubMed31530502

2019

Increased proton-sensing receptor GPR4 signalling promotes colorectal cancer progression by activating the hippo pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Minhao Yu,Ran Cui,Yizhou Huang,Yang Luo,Shaolan Qin,Ming Zhong
View all publications
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