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AB122229

Anti-SLC4A10 antibody

5

(1 Review)

|

(1 Publication)

Rabbit Polyclonal SLC4A10 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC4A10 aa 600 to C-terminus.

View Alternative Names

NBCN2, NCBE, SLC4A10, Sodium-driven chloride bicarbonate exchanger, Solute carrier family 4 member 10

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC4A10 antibody (AB122229)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC4A10 antibody (AB122229)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lymph node tissue labelling SLC4A10 with ab122229 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC4A10 antibody (AB122229)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC4A10 antibody (AB122229)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human cerebellum tissue labelling SLC4A10 with ab122229 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC4A10 antibody (AB122229)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC4A10 antibody (AB122229)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human fallopian tube tissue labelling SLC4A10 with ab122229 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC4A10 antibody (AB122229)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC4A10 antibody (AB122229)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human cerebral cortex tissue labelling SLC4A10 with ab122229 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SLC4A10 aa 600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q6U841

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLC4A10 also known as NCBE (Na+-driven Cl-/HCO3- exchanger) is a member of the SLC4 family of bicarbonate transporters. It has a molecular mass of approximately 121 kDa. This protein functions in the exchange of bicarbonate (HCO3-) and chloride (Cl-) ions in cells and tissues facilitating the regulation of intracellular pH and bicarbonate homeostasis. SLC4A10 is strongly expressed in the brain particularly in structures like the cerebellum and hippocampus and is also present in other tissues such as the eyes and intestines. Its expression pattern indicates its role in specialized physiological processes requiring ion balance.
Biological function summary

The functions of SLC4A10 are integral to neuronal ion balance and signaling. It transports ions across membranes contributing to the maintenance of pH in neural tissues important for neurotransmission and neuronal excitability. SLC4A10 does not function as part of a larger protein complex but interacts with other ion transport systems to maintain cellular ion homeostasis. Its activity ensures neurons efficiently communicate and respond to stimuli by modulating synaptic activity and plasticity supporting normal brain functions.

Pathways

SLC4A10 plays roles in acid-base balance and ion transport pathways. It contributes significantly to the bicarbonate reclamation pathway which maintains pH balance within the central nervous system. This exchanger closely interacts with other transport proteins like SLC4A3/Band 3 and SLC4A7 to coordinate bicarbonate transport. The coordinated activity among these proteins allows fine-tuning of cellular ion exchange regulation pivotal in maintaining neurotransmitter release and responsive neural activity.

SLC4A10 has associations with neurological conditions such as epilepsy and migraine. Studies have highlighted that dysfunctional SLC4A10 may lead to improper ion homeostasis which can predispose individuals to these disorders. Mutations or dysregulation of this protein can disrupt the ion balance within neurons leading to increased susceptibility to seizures and migraines. In the context of these disorders SLC4A10 may interact with other neuronal proteins such as the GABA transporter SLC6A1 affecting inhibitory signaling pathways and contributing to pathological neuronal excitability.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (PubMed : 18319254). Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (By similarity). Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (PubMed : 18319254). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similarity). Acting on presynaptic intracellular pH, it promotes GABA release, reduces the excitability of CA1 pyramidal neurons, and modulates short-term synaptic plasticity (By similarity). Required in retinal cells to maintain normal pH which is necessary for normal vision (By similarity). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (By similarity).
See full target information SLC4A10
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Molecular biology reports 51:385 PubMed38438773

2024

CDKN2A promoter methylation enhances self-renewal of glioblastoma stem cells and confers resistance to carmustine.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Wang,Yan-Feng Xi,Qi Zhao,Jiang-Hong Guo,Zhen Zhang,Mao-Bai Zhang,Jiang Chang,Yue-Qin Wu,Wen Su
View all publications
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Product promise

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