Rabbit Polyclonal SLC4A11 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SLC4A11 aa 50-200.
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Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human SLC4A11 aa 50-200. The exact immunogen used to generate this antibody is proprietary information. Database link Q8NBS3
Reactivity data
Select an application| IHC-P | |
|---|---|
| Human | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target data
Function
Multifunctional transporter with an impact in cell morphology and differentiation. In the presence of borate B(OH)4(-), acts as a voltage-dependent electrogenic Na(+)-coupled B(OH)4(-) cotransporter controlling boron homeostasis (PubMed:15525507). At early stages of stem cell differentiation, participates in synergy with ITGA5-ITGB1 and ITGAV-ITGB3 integrins and BMPR1A to promote cell adhesion and contractility that drives differentiation toward osteogenic commitment while inhibiting adipogenesis (By similarity). In the absence of B(OH)4(-), acts as a Na(+)-coupled OH(-) or H(+) permeable channel with implications in cellular redox balance (PubMed:15525507, PubMed:28642546). Regulates the oxidative stress response in corneal endothelium by enhancing antioxidant defenses and protecting cells from reactive oxygen species (PubMed:28642546). In response to hypo-osmotic challenge, also acts as a water permeable channel at the basolateral cell membrane of corneal endothelial cells and facilitates transendothelial fluid reabsorption in the aqueous humor (PubMed:23813972, PubMed:25007886, PubMed:31273259). In the presence of ammonia, acts as an electrogenic NH3/H(+) cotransporter and may play a role in ammonia transport and reabsorption in renal Henle's loop epithelium (PubMed:27581649).
Alternative names
BTR1, SLC4A11, Solute carrier family 4 member 11, Sodium borate cotransporter 1, NaBC1
Recommended products
Rabbit Polyclonal SLC4A11 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SLC4A11 aa 50-200.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human SLC4A11 aa 50-200. The exact immunogen used to generate this antibody is proprietary information. Database link Q8NBS3
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SLC4A11 also known as solute carrier family 4 member 11 functions as a bicarbonate transporter belonging to the SLC4 family. This protein has a mass of approximately 95 kDa. SLC4A11 localizes mainly in the basolateral membranes of kidney cells and also in the corneal endothelium. It plays a vital role in maintaining ion balance and pH regulation within cells by mediating the transport of bicarbonate ions across cellular membranes.
- Biological function summary
The proper functioning of ion transport impacts cellular homeostasis and fluid regulation. SLC4A11 does not form part of a complex but interacts directly with ions and molecules. This protein contributes significantly to the maintenance of normal cell volume and osmotic balance especially in epithelial tissues where ion exchange is important for cellular function and integrity.
- Pathways
Transport of bicarbonate ions supports central metabolic pathways contributing to the regulation of intracellular pH. The protein plays a role in the bicarbonate reclamation pathway and interacts with proteins like carbonic anhydrase which catalyzes the conversion of carbon dioxide and bicarbonate. This interaction highlights SLC4A11's significance in buffering and acid-base balance within specific cell types.
- Associated diseases and disorders
Alterations in SLC4A11 lead to conditions such as congenital hereditary endothelial dystrophy (CHED) and Harboyan syndrome. Both disorders connect to ion imbalances affecting the corneal endothelium compromising cell function and vision. Mutations in this protein can disrupt its interactions with carbonic anhydrases further exacerbating pH imbalance and cellular dysfunctions associated with these diseases.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC4A11 antibody (ab251719)
Paraffin-embedded human testis tissue stained for SLC4A11 using ab251719 at 1/50 dilution in immunohistochemical analysis.
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