JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB140974

Anti-SLC5A6 antibody

0

(1 Review)

|

(1 Publication)

Rabbit Polyclonal SLC5A6 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SLC5A6.

View Alternative Names

SMVT, SLC5A6, Sodium-dependent multivitamin transporter, Na(+)-dependent multivitamin transporter, hSMVT, Solute carrier family 5 member 6

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC5A6 antibody (AB140974)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC5A6 antibody (AB140974)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human placenta tissue labeling SLC5A6 with ab140974 at 10 µg/ml.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human SLC5A6. The exact immunogen used to generate this antibody is proprietary information.

Q9Y289

Specificity

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

style
left-column

Alternative Products

Primary Antibodies

AB137214

Anti-SLC5A6 antibody

Western blot - Anti-SLC5A6 antibody (AB137214)

  • 1
  • 1

Complementary Products

Primary Antibodies

AB234723

Anti-TBC1D24 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TBC1D24 antibody (AB234723)

  • 0
  • 0
Proteins & Peptides

AB217407

Recombinant human Vitronectin/S-Protein (Animal Free)

  • 0
  • 0
Proteins & Peptides

AB280753

Recombinant Human PD1 protein

Mass Spectrometry - Recombinant Human PD1 protein (AB280753)

  • 0
  • 0
Proteins & Peptides

AB198115

Recombinant Human Histone H4 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human Histone H4 protein (His tag N-Terminus) (AB198115)

  • 0
  • 0
style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Bat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Elephant": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Hamster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Platypus": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLC5A6 also known as the sodium-dependent multivitamin transporter (SMVT) mechanically functions as a transmembrane protein responsible for the uptake of vital water-soluble vitamins and cofactors such as biotin pantothenic acid and lipoate. The protein has an approximate molecular mass of 72 kDa. It is expressed in various tissues with high levels observed in the intestines kidneys and placenta indicating its role in nutrient absorption and metabolic processes.
Biological function summary

SLC5A6 is essential for the efficient transport of vitamins across cell membranes using sodium gradient as the driving force. It transports vitamins into cells where they participate as coenzymes in several enzymatic reactions. This transporter does not form part of a larger protein complex but functions individually to link dietary intake with cellular nutrient requirements. The absorption through SLC5A6 impacts various biosynthetic processes as biotin and pantothenate contribute to fatty acid synthesis and energy metabolism.

Pathways

The role of SLC5A6 in nutrient absorption connects it to critical metabolic pathways such as the biotin and CoA biosynthetic pathways. Its function impacts cellular metabolism by providing essential cofactors for carboxylation reactions and energy production. SLC5A6 interacts with enzymes that rely on these vitamin-derived cofactors maintaining cellular metabolic equilibrium essential for cell growth and energy balance.

Mutations or dysfunction in SLC5A6 can lead to conditions like biotinidase deficiency which results in various neurological and dermatological symptoms. There are connections between SLC5A6 malfunctions and certain metabolic disorders due to impaired nutrient uptake linking this transporter to proteins involved in biotin metabolism. Research indicates possible associations of SLC5A6 with neurological disorders as biotin deficiency impacts brain functions and development.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide (PubMed : 10329687, PubMed : 15561972, PubMed : 19211916, PubMed : 20980265, PubMed : 21570947, PubMed : 22015582, PubMed : 25809983, PubMed : 25971966, PubMed : 27904971, PubMed : 28052864, PubMed : 31754459). Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+) : substrate is 2 : 1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake (PubMed : 10329687, PubMed : 20980265). Required for biotin and pantothenate uptake in the intestine across the brush border membrane (PubMed : 19211916). Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (By similarity). Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier (PubMed : 25809983).
See full target information SLC5A6
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncotarget 9:13733-13747 PubMed29568390

2018

Characterization of brain tumor initiating cells isolated from an animal model of CNS primitive neuroectodermal tumors.

Applications

Unspecified application

Species

Unspecified reactive species

Sergey Malchenko,Simone T Sredni,Jerusha Boyineni,Yingtao Bi,Naira V Margaryan,Maheedhara R Guda,Yulia Kostenko,Tadanori Tomita,Ramana V Davuluri,Kiran Velpula,Mary J C Hendrix,Marcelo B Soares
View all publications
style
left-column
style
left-column
style
right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com