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AB191192

Anti-SLC6A15 antibody

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Rabbit Polyclonal SLC6A15 antibody. Suitable for IP, WB and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human SLC6A15 aa 650-700.

View Alternative Names

B0AT2, NTT73, SBAT1, SLC6A15, Sodium-dependent neutral amino acid transporter B(0)AT2, Sodium- and chloride-dependent neurotransmitter transporter NTT73, Sodium-coupled branched-chain amino-acid transporter 1, Solute carrier family 6 member 15, Transporter v7-3

2 Images
Immunoprecipitation - Anti-SLC6A15 antibody (AB191192)
  • IP

Supplier Data

Immunoprecipitation - Anti-SLC6A15 antibody (AB191192)

Detection of SLC6A15 in Immunoprecipitates of 293T whole cell lysates (1 mg for IP, 20% of IP loaded) using ab191192 at 6 μg/reaction for IP and 0.4 μg/ml for WB detection (Lane 1). Lane 2 represents control IgG IP. Detection : Chemiluminescence with an exposure time of 30 seconds.

All lanes:

Immunoprecipitation - Anti-SLC6A15 antibody (ab191192)

Predicted band size: 82 kDa

false

Western blot - Anti-SLC6A15 antibody (AB191192)
  • WB

Supplier Data

Western blot - Anti-SLC6A15 antibody (AB191192)

All lanes:

Western blot - Anti-SLC6A15 antibody (ab191192) at 0.1 µg/mL

Lane 1:

HeLa whole cell lysate at 50 µg

Lane 2:

293T whole cell lysate at 50 µg

Lane 3:

Jurkat whole cell lysate at 50 µg

Predicted band size: 82 kDa

true

Exposure time: 3min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IP, WB

applications

Immunogen

Synthetic Peptide within Human SLC6A15 aa 650-700. The exact immunogen used to generate this antibody is proprietary information.

Q9H2J7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-10 µg/mg of lysate", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
ab191192 was affinity purified using an epitope specific to SLC6A15 immobilized on solid support.
Storage buffer
pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLC6A15 also known as sodium-dependent amino acid transporter B(0)AT2 is a protein involved in the transport of amino acids across cellular membranes in a sodium-dependent manner. This protein's mass is approximately 73 kDa. It is expressed mostly in the brain kidney and small intestine where it plays an important role in maintaining amino acid homeostasis within cells.
Biological function summary

The transporter plays a significant role in neurotransmitter regulation by facilitating the uptake of neutral amino acids which serve as precursors for neurotransmitter synthesis. It is not known to be part of a larger complex which allows it functional specificity in the transport processes it mediates. The protein's activity impacts neurological functions and metabolic processes through its influence on amino acid availability.

Pathways

SLC6A15 significantly contributes to amino acid transport pathways particularly those critical for the central nervous system's function. This transporter interacts closely with proteins such as B0AT1 which also participates in similar transport activities. The pathways that incorporate SLC6A15 contribute to maintaining the balance of amino acids in the brain which are necessary for cognitive processes and metabolism.

SLC6A15's dysregulation has been associated with major depressive disorder and obesity. This link may be due to its vital role in amino acid supply for neurotransmitter production and metabolic regulation. Proteins such as serotonin transporter (SERT) might be affected due to alterations in amino acid availability impacting mood and metabolic balance. Understanding this protein's function in these conditions could offer insights into new therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1 : 1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent.
See full target information SLC6A15
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