AB230890

Anti-SLC6A15 antibody - N-terminal

Name: Anti-SLC6A15 antibody - N-terminal (ab230890) | Abcam
Brand: Abcam Limited
SKU: AB230890
Price: 605 USD
Availability: InStock

Be the first to review this product! Submit a review

(1 Publication)

Rabbit Polyclonal SLC6A15 antibody. N-terminal. Suitable for IHC-P, WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SLC6A15 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

B0AT2, NTT73, SBAT1, SLC6A15, Sodium-dependent neutral amino acid transporter B(0)AT2, Sodium- and chloride-dependent neurotransmitter transporter NTT73, Sodium-coupled branched-chain amino-acid transporter 1, Solute carrier family 6 member 15, Transporter v7-3

2 Images

Supplier Data

Western blot - Anti-SLC6A15 antibody - N-terminal (AB230890)

All lanes:

Western blot - Anti-SLC6A15 antibody - N-terminal (ab230890) at 1/500 dilution

Lane 1:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate

Lane 2:

Mouse brain whole cell lysate

Lane 3:

Rat brain whole cell lysate

Predicted band size: 82 kDa

true

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC6A15 antibody - N-terminal (AB230890)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC6A15 antibody - N-terminal (AB230890)

Formalin-fixed, paraffin-embedded human brain cortex tissue stained for SLC6A15 with ab230890 at a 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat, Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human SLC6A15 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9H2J7

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": " Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "" }, "Mouse": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

style

left-column

style

left-column

Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.3 Preservative: 0.01% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

style

left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLC6A15 also known as sodium-dependent amino acid transporter B(0)AT2 is a protein involved in the transport of amino acids across cellular membranes in a sodium-dependent manner. This protein's mass is approximately 73 kDa. It is expressed mostly in the brain kidney and small intestine where it plays an important role in maintaining amino acid homeostasis within cells.

Biological function summary

The transporter plays a significant role in neurotransmitter regulation by facilitating the uptake of neutral amino acids which serve as precursors for neurotransmitter synthesis. It is not known to be part of a larger complex which allows it functional specificity in the transport processes it mediates. The protein's activity impacts neurological functions and metabolic processes through its influence on amino acid availability.

Pathways

SLC6A15 significantly contributes to amino acid transport pathways particularly those critical for the central nervous system's function. This transporter interacts closely with proteins such as B0AT1 which also participates in similar transport activities. The pathways that incorporate SLC6A15 contribute to maintaining the balance of amino acids in the brain which are necessary for cognitive processes and metabolism.

SLC6A15's dysregulation has been associated with major depressive disorder and obesity. This link may be due to its vital role in amino acid supply for neurotransmitter production and metabolic regulation. Proteins such as serotonin transporter (SERT) might be affected due to alterations in amino acid availability impacting mood and metabolic balance. Understanding this protein's function in these conditions could offer insights into new therapeutic strategies.

style

left-column

style

left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

Target data

Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1 : 1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent.

See full target information SLC6A15

style

left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Human reproduction (Oxford, England) 40:119-137 PubMed39521729

2024

Upregulated let-7 expression in the follicular fluid of patients with endometriomas leads to dysfunction of granulosa cells through targeting of IGF1R.

Applications

Unspecified application

Species

Unspecified reactive species

Libing Shi,Hanqi Ying,Yongdong Dai,Yan Rong,Jianmin Chen,Feng Zhou,Shasha Wang,Shiqian Xu,Xiaomei Tong,Songying Zhang

View all publications

style

left-column

style

left-column

style

right-column

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SLC6A15 antibody - N-terminal

Western blot - Anti-SLC6A15 antibody - N-terminal (AB230890)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC6A15 antibody - N-terminal (AB230890)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Alternative Products

Primary Antibodies

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Product promise