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Rabbit Polyclonal SLC7A14 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SLC7A14 aa 450-550.

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Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS, 40% Glycerol (glycerin, glycerine)

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human SLC7A14 aa 450-550. The exact immunogen used to generate this antibody is proprietary information. Database link Q8TBB6
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Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IHC-P
Human
Tested
Mouse
Predicted
Cow
Predicted

Tested
Tested

Species

Human

Dilution info

1/500.00000 - 1/1000.00000

Notes

Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Predicted
Predicted

Species

Mouse, Cow

Dilution info

-

Notes

-

Target data

Function

May be involved in arginine transport.

Alternative names

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Rabbit Polyclonal SLC7A14 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human SLC7A14 aa 450-550.

Alternative names

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human SLC7A14 aa 450-550. The exact immunogen used to generate this antibody is proprietary information. Database link Q8TBB6
Purification technique

Affinity purification Immunogen

Concentration
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Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

Biological function summary

The SLC7A14 protein contributes to the broader role of maintaining proper cellular communication and transport activities. It forms part of the larger solute carrier family known for their role in amino acid transport across cell membranes. While SLC7A14 has not been described as part of a large protein complex its function complements other amino acid transporters ensuring the distribution and balance of these essential molecules within neural tissue.

Activity summary

The SLC7A14 protein also known by alternate names like solute carrier family 7 member 14 is a transmembrane protein that functions as a transporter. It has a molecular mass of approximately 80 kDa. SLC7A14 is expressed prominently in retinal cells and the central nervous system indicating a specialized role in neural tissues. It seems to span the cellular membrane to facilitate the flux of specific amino acids or their derivatives therefore playing a role in cellular homeostasis and signaling.

Pathways

SLC7A14's role extends to involvement in neurotransmitter and metabolic pathways. It participates in amino acid transport connecting to pathways like the mammalian target of rapamycin (mTOR) signaling and glutamate metabolism important for energy balance and synaptic function. Related proteins include other members of the SLC7 family such as SLC7A8 and SLC7A10 which share similar transport capabilities but differ in substrate specificity and expression patterns.

Associated diseases and disorders

SLC7A14 has been associated with retinal degenerative conditions such as retinitis pigmentosa. Mutations in the SLC7A14 gene can lead to defects in retinal cells disrupting visual signal processing. This protein also hints at a possible link with neurodegenerative disorders given its expression in the central nervous system and its role in amino acid transport though research continues to explore these connections. In retinitis pigmentosa SLC7A14 may interact with proteins involved in photoreceptor maintenance or survival highlighting its relevance in ocular health.

Product promise

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1 product image

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC7A14 antibody (ab224572), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC7A14 antibody (ab224572)

    Paraffin-embedded human hippocampus tissue stained for SLC7A14 using ab224572 at 1/1000 dilution in immunohistochemical analysis.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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