Anti-SLC7A14 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The SLC7A14 protein also known by alternate names like solute carrier family 7 member 14 is a transmembrane protein that functions as a transporter. It has a molecular mass of approximately 80 kDa. SLC7A14 is expressed prominently in retinal cells and the central nervous system indicating a specialized role in neural tissues. It seems to span the cellular membrane to facilitate the flux of specific amino acids or their derivatives therefore playing a role in cellular homeostasis and signaling.

Biological function summary

The SLC7A14 protein contributes to the broader role of maintaining proper cellular communication and transport activities. It forms part of the larger solute carrier family known for their role in amino acid transport across cell membranes. While SLC7A14 has not been described as part of a large protein complex its function complements other amino acid transporters ensuring the distribution and balance of these essential molecules within neural tissue.

Pathways

SLC7A14's role extends to involvement in neurotransmitter and metabolic pathways. It participates in amino acid transport connecting to pathways like the mammalian target of rapamycin (mTOR) signaling and glutamate metabolism important for energy balance and synaptic function. Related proteins include other members of the SLC7 family such as SLC7A8 and SLC7A10 which share similar transport capabilities but differ in substrate specificity and expression patterns.

Associated diseases and disorders

SLC7A14 has been associated with retinal degenerative conditions such as retinitis pigmentosa. Mutations in the SLC7A14 gene can lead to defects in retinal cells disrupting visual signal processing. This protein also hints at a possible link with neurodegenerative disorders given its expression in the central nervous system and its role in amino acid transport though research continues to explore these connections. In retinitis pigmentosa SLC7A14 may interact with proteins involved in photoreceptor maintenance or survival highlighting its relevance in ocular health.