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AB140831

Anti-SLC7A2/CAT2 antibody

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(3 Publications)

Rabbit Polyclonal SLC7A2/CAT2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human SLC7A2.

View Alternative Names

ATRC2, CAT2, SLC7A2, Cationic amino acid transporter 2, CAT-2, Low affinity cationic amino acid transporter 2, Solute carrier family 7 member 2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC7A2/CAT2 antibody (AB140831)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC7A2/CAT2 antibody (AB140831)

Immunohistochemical analysis of formalin-fixed, paraffin embedded Human adrenal tissue, labelling SLC7A2/CAT2 with ab140831 at 15 μg/ml followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC7A2/CAT2 antibody (AB140831)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC7A2/CAT2 antibody (AB140831)

Immunohistochemical analysis of formalin-fixed, paraffin embedded Human stomach tissue, labelling SLC7A2/CAT2 with ab140831 at 15 μg/ml followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human SLC7A2. The exact immunogen used to generate this antibody is proprietary information.

P52569

Specificity

BLAST analysis of the peptide immunogen showed no homology with other human proteins, except TPR (67%).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "15 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Bat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Hamster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLC7A2 commonly known as CAT2 functions as a cationic amino acid transporter. This protein weighs around 72 kDa and is essential for the uptake of cationic amino acids such as arginine lysine and ornithine. Expression of SLC7A2 happens in various tissues including liver kidney and skeletal muscle. It is a member of the larger solute carrier family specifically the SLC7 family which plays roles in transporting nutrients across the cell membrane.
Biological function summary

SLC7A2 contributes to the regulation of nitric oxide production by modulating the intracellular availability of arginine an important substrate for nitric oxide synthase. The protein does not appear to work as a part of a well-characterized complex but its independent activity can significantly influence cellular functions. By impacting arginine transport SLC7A2 affects various cellular processes like immune response and vascular function.

Pathways

SLC7A2 serves a role in the nitric oxide synthesis pathway and the urea cycle. It interacts indirectly with proteins such as nitric oxide synthase which requires arginine supplied by SLC7A2 for nitric oxide production. SLC7A2 influences pathways like vasodilation and immune signaling by controlling the movement and availability of its substrate amino acids.

Misregulation or mutation of SLC7A2 links to hypertensive disorders and certain metabolic syndromes. The protein's role in arginine transport connects to situations such as endothelial dysfunction where reduced nitric oxide levels lead to cardiovascular issues. Researchers study its relationship with nitric oxide synthase further to understand the mechanistic basis of these health conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Functions as a permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine); the affinity for its substrates differs between isoforms created by alternative splicing (PubMed : 28684763, PubMed : 9174363). May play a role in classical or alternative activation of macrophages via its role in arginine transport (By similarity).. Isoform 1. Functions as a permease that mediates the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine). Shows a much higher affinity for L-arginine and L-homoarginine than isoform 2.. Isoform 2. Functions as a low-affinity, high capacity permease involved in the transport of the cationic amino acids (L-arginine, L-lysine, L-ornithine and L-homoarginine).
See full target information SLC7A2
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

British journal of pharmacology 179:2193-2207 PubMed34766332

2022

Glucosylsphingosine evokes pruritus via activation of 5-HT receptor and TRPV4 in sensory neurons.

Applications

Unspecified application

Species

Unspecified reactive species

Babina Sanjel,Bo-Hyun Kim,Myung-Hyun Song,Earl Carstens,Won-Sik Shim

Cell death & disease 12:570 PubMed34108444

2021

SLC7A2 deficiency promotes hepatocellular carcinoma progression by enhancing recruitment of myeloid-derived suppressors cells.

Applications

Unspecified application

Species

Unspecified reactive species

Suhong Xia,Jingwen Wu,Wangdong Zhou,Mingyu Zhang,Kai Zhao,Jingmei Liu,Dean Tian,Jiazhi Liao

Journal of animal science 99: PubMed33247721

2020

The effects of maternal nutrition during the first 50 d of gestation on the location and abundance of hexose and cationic amino acid transporters in beef heifer uteroplacental tissues.

Applications

Unspecified application

Species

Unspecified reactive species

Matthew S Crouse,Kyle J McLean,Josephine Dwamena,Tammi L Neville,Ana Clara B Menezes,Alison K Ward,Lawrence P Reynolds,Carl R Dahlen,Bryan W Neville,Pawel P Borowicz,Joel S Caton
View all publications
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Product promise

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