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AB122727

Anti-SLC7A6OS antibody

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(2 Publications)

Rabbit Polyclonal SLC7A6OS antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLC7A6OS aa 1-150.

View Alternative Names

Probable RNA polymerase II nuclear localization protein SLC7A6OS, ADAMS proteinase-related protein, Solute carrier family 7 member 6 opposite strand transcript, SLC7A6OS

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC7A6OS antibody (AB122727)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLC7A6OS antibody (AB122727)

ab122727, at 1/500 dilution, staining SLC7A6OS in paraffin-embedded Human testis tissue by Immunohistochemistry.

Immunocytochemistry/ Immunofluorescence - Anti-SLC7A6OS antibody (AB122727)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SLC7A6OS antibody (AB122727)

Immunocytochemistry/Immunofluorescence analysis of U-2 OS cells labelling SLC7A6OS with ab122727 shows positivity in the nucleus but is excluded from the nucleoli.

Western blot - Anti-SLC7A6OS antibody (AB122727)
  • WB

Supplier Data

Western blot - Anti-SLC7A6OS antibody (AB122727)

All lanes:

Western blot - Anti-SLC7A6OS antibody (ab122727) at 0.4 µg/mL

Lane 1:

Control (vector only transfected) - HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate

Lane 2:

SLC7A6OS over-expression - HEK-293T whole cell lysate, Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa)

Predicted band size: 35 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human SLC7A6OS aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q96CW6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle|Store undiluted
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLC7A6OS also known as C20orf51 or JmjN domain containing 1 is a protein that does not have a well-characterized function yet but researchers have identified it in some cellular processes. It has an approximate mass of 60 kDa. SLC7A6OS expresses broadly across different tissues in the human body including the liver and brain. In cells it appears to localize to both cytoplasm and nucleus indicating roles in diverse cellular environments.
Biological function summary

This protein appears to associate with certain cellular processes though not well-understood. Some studies suggest that it associates with complexes involved in protein degradation and RNA splicing. In these processes SLC7A6OS might contribute to regulation or stability of protein interactions or RNA molecules. This suggests a potential role in maintenance of cellular functions although the precise mechanisms remain to be fully elucidated.

Pathways

SLC7A6OS might interact within regulatory networks involving protein turnover or gene expression control. Specifically researchers postulate a possible involvement in the ubiquitin-proteasome pathway due to its association with protein degradation machinery. This pathway plays an essential role in controlling protein levels in cells. The protein might also connect indirectly with components of the spliceosome a complex important for mRNA processing although direct connections require further research.

Scientists are exploring links between SLC7A6OS and neurodegenerative conditions given its expression in brain tissue. Researchers are investigating its potential association with disorders like Alzheimer's disease where protein aggregation and degradation are key features. SLC7A6OS might interact or co-regulate with proteins involved in these diseases such as tau proteins or ubiquitin ligases linked to protein degradation. Understanding its role in these conditions can help reveal potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Directs RNA polymerase II nuclear import.
See full target information SLC7A6OS
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

International journal of medical sciences 20:1235-1239 PubMed37575271

2023

Prognostic and Clinical Implications of UNC13C expression in Hepatocellular Carcinoma Patients.

Applications

Unspecified application

Species

Unspecified reactive species

V Bharath Kumar,Chien-Hsun Lee,Tzu-Cheng Su,Chia-Chieh Lin,Zuhair M Mohammedsaleh,Chung-Min Yeh,Rudolf Kiefer,Shu-Hui Lin

Annals of neurology 89:402-407 PubMed33085104

2020

Progressive Myoclonus Epilepsy Caused by a Homozygous Splicing Variant of SLC7A6OS.

Applications

Unspecified application

Species

Unspecified reactive species

Laure Mazzola,Karen L Oliver,Audrey Labalme,Betül Baykan,Mikko Muona,Tarja H Joensuu,Carolina Courage,Nicolas Chatron,Giuseppe Borsani,Eudeline Alix,Francis Ramond,Renaud Touraine,Melanie Bahlo,Nerses Bebek,Samuel F Berkovic,Anna-Elina Lehesjoki,Gaetan Lesca
View all publications
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