Anti-SLCO1B3/OATP1B3 antibody [CL3770]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

SLCO1B3 also known as OATP1B3 is an organic anion transporting polypeptide with a mass of approximately 84 kDa. It functions as a transporter involved in the uptake of various endogenous and exogenous compounds. Mechanically OATP1B3 facilitates the movement of bile acids hormones and drugs across the basolateral membrane in hepatocytes. It is expressed mainly in the liver where it plays a significant role in drug metabolism and disposition.

Biological function summary

OATP1B3 impacts several physiological processes notably the clearance and systemic availability of drugs and endogenous compounds. It is not considered part of a larger protein complex but works closely with other transporters to regulate the hepatobiliary system. Through its selective transport of substrates OATP1B3 contributes to maintaining homeostasis and proper liver function ensuring efficient detoxification and excretion.

Pathways

OATP1B3 plays a role in the enterohepatic circulation of bile acids and drug metabolism pathways. The transporter influences the pharmacokinetics of many drugs and interacts with related proteins such as CYP3A4 which metabolizes these substrates following their uptake. By mediating hepatic uptake OATP1B3 serves as a gatekeeper within the drug metabolism and disposition process managing entry into the liver for further processing by these enzyme systems.

Associated diseases and disorders

OATP1B3 has associations with liver-related conditions such as cholestasis and liver cancer. Impaired function or expression of OATP1B3 can lead to altered pharmacokinetics contributing to drug-induced liver injury. Additionally it interacts with proteins like MRP2 which is involved in the excretion of conjugated bile acids. Understanding the role of OATP1B3 in these diseases provides insights into potential therapeutic strategies and drug development.