AB234729

Anti-SLCO1C1 antibody

Name: Anti-SLCO1C1 antibody (ab234729) | Abcam
Brand: Abcam Limited
SKU: AB234729

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(4 Publications)

Rabbit Polyclonal SLCO1C1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SLCO1C1 aa 50-350.

View Alternative Names

OATP14, OATP1C1, OATPF, SLC21A14, SLCO1C1, Solute carrier organic anion transporter family member 1C1, Organic anion transporter 1C1, Organic anion transporter F, Organic anion transporter polypeptide-related protein 5, Organic anion-transporting polypeptide 14, Solute carrier family 21 member 14, Thyroxine transporter, OATP-F, OAT-RP-5, OATP-RP5, OATP-14

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLCO1C1 antibody (AB234729)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLCO1C1 antibody (AB234729)

Paraffin-embedded human testis tissue stained for SLCO1C1 with ab234729 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-SLCO1C1 antibody (AB234729)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SLCO1C1 antibody (AB234729)

HepG2 (human liver hepatocellular carcinoma cell line) cells stained for SLCO1C1 using ab234729 at a dilution of 1/100 in ICC/IF. Secondary antibody is an Alexa-Fluor^®488-conjugated Goat Anti-Rabbit IgG (H+L).

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human SLCO1C1 aa 50-350. The exact immunogen used to generate this antibody is proprietary information.

Q9NYB5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein G

Purification notes

Purity >95%

Storage buffer

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLCO1C1 also known as OATP1C1 is an important protein that functions as a solute carrier transporting organic ions across cell membranes. This protein has a molecular mass of approximately 76 kDa. SLCO1C1 is mainly expressed in the brain particularly in the blood-brain barrier and the choroid plexus. By mediating the passage of hormones and other molecules into the brain it plays a pivotal role in maintaining central nervous system function.

Biological function summary

This transporter facilitates the uptake of thyroid hormones such as thyroxine (T4) and triiodothyronine (T3) into the brain. Thyroid hormones are critical for brain development and function and SLCO1C1 plays a significant role in regulating their levels in the central nervous system. It does not work alone interacting with other proteins like thyroid hormone receptors to ensure proper hormone signaling in neuronal tissues.

Pathways

Thyroid hormone transport involves SLCO1C1 as well as its engagement with hormonal signaling pathways. These pathways include the regulation of metabolic processes and neural development which are essential for normal physiological function. SLCO1C1 also interacts with proteins such as MCT8 another thyroid hormone transporter integrating thyroid hormone distribution into the broader metabolic network within the brain.

Abnormal function or expression of SLCO1C1 can contribute to central nervous system disorders including neurological conditions linked to thyroid hormone imbalances like Allan-Herndon-Dudley syndrome. Research indicates that mutations or dysfunctions in SLCO1C1 along with related proteins like MCT8 could impair normal thyroid hormone transport leading to developmental and cognitive issues. Understanding SLCO1C1's role in these disorders offers possibilities for therapeutic interventions targeting thyroid hormone regulation in the brain.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones L-thyroxine (T4), L-thyroxine sulfate (T4S), and 3,3',5'-triiodo-L-thyronine (reverse T3, rT3) at the plasma membrane (PubMed : 12351693, PubMed : 18566113, PubMed : 19129463). Regulates T4 levels in different brain regions by transporting T4, and also by serving as an export pump for T4S, which is a source of T4 after hydrolysis by local sulfatases (PubMed : 18566113). Increases the access of these substrates to the intracellular sites where they are metabolized by the deiodinases (PubMed : 18566113). Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol (17beta-estradiol 17-O-(beta-D-glucuronate)), estrone-3-sulfate (E1S) and sulfobromophthalein (BSP) are transported with much lower efficiency (PubMed : 12351693, PubMed : 19129463). Transports T4 and E1S in a pH-insensitive manner (PubMed : 19129463). Facilitates the transport of thyroid hormones across the blood-brain barrier and into glia and neuronal cells in the brain (PubMed : 30296914).

See full target information SLCO1C1

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Journal of translational medicine 23:69 PubMed39810250

2025

Lactate accumulation promotes immunosuppression and fibrotic transformation of bone marrow microenvironment in myelofibrosis.

Applications

Unspecified application

Species

Unspecified reactive species

Mariarita Spampinato,Cesarina Giallongo,Sebastiano Giallongo,Enrico La Spina,Andrea Duminuco,Lucia Longhitano,Rosario Caltabiano,Lucia Salvatorelli,Giuseppe Broggi,Elisabetta P Pricoco,Vittorio Del Fabro,Ilaria Dulcamare,Antonio Massimo DI Mauro,Alessandra Romano,Francesco Di Raimondo,Giovanni Li Volti,Giuseppe A Palumbo,Daniele Tibullo

International journal of molecular sciences 24: PubMed37298594

2023

Thyroid Hormone Transporters MCT8 and OATP1C1 Are Expressed in Projection Neurons and Interneurons of Basal Ganglia and Motor Thalamus in the Adult Human and Macaque Brains.

Applications

Unspecified application

Species

Unspecified reactive species

Ting Wang,Yu Wang,Ana Montero-Pedrazuela,Lucía Prensa,Ana Guadaño-Ferraz,Estrella Rausell

Neuro-oncology advances 4:vdac166 PubMed36382105

2022

Single-cell image analysis reveals over-expression of organic anion transporting polypeptides (OATPs) in human glioblastoma tissue.

Applications

Unspecified application

Species

Unspecified reactive species

Elizabeth Cooper,Zoe Woolf,Molly E V Swanson,Jason Correia,Patrick Schweder,Edward Mee,Peter Heppner,Clinton Turner,Richard L M Faull,Emma L Scotter,William A Denny,Peter J Choi,Mike Dragunow,Jiney Jose,Thomas I-H Park

Frontiers in endocrinology 12:664839 PubMed34122338

2021

Decreased Expression of Ileal Thyroid Hormone Transporters in a Hypothyroid Patient: A Case Report.

Applications

Unspecified application

Species

Unspecified reactive species

Chae Won Chung,Eun Young Mo,Gyung Seo Jung,Yoo Hyung Kim,Sun Wook Cho,Do Joon Park,Jeong Mo Bae,Young Joo Park

View all publications

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Product promise

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-SLCO1C1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLCO1C1 antibody (AB234729)

Immunocytochemistry/ Immunofluorescence - Anti-SLCO1C1 antibody (AB234729)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

Product promise