Skip to main content

Rabbit Recombinant Monoclonal SLCO2B1/OATP2B1 antibody. Carrier free. Suitable for WB and reacts with Human samples.

Be the first to review this product! Submit a review

Images

Western blot - Anti-SLCO2B1/OATP2B1 antibody [EPR22212-37] - BSA and Azide free (AB245829), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

pH: 7.2 - 7.4
Constituents: PBS

Form

Liquid

Clonality

Monoclonal

Immunogen

  • The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
IPFlow CytWBIHC-PICC/IF
Human
Not recommended
Not recommended
Tested
Not recommended
Not recommended

Not recommended
Not recommended

Species

Human

Dilution info

-

Notes

-

Not recommended
Not recommended

Species

Human

Dilution info

-

Notes

-

Tested
Tested

Species

Human

Dilution info

-

Notes

-

Not recommended
Not recommended

Species

Human

Dilution info

-

Notes

-

Not recommended
Not recommended

Species

Human

Dilution info

-

Notes

-

Associated Products

Select an associated product type

3 products for Alternative Product

    1 products for Alternative Version

      Target data

      Function

      Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost.

      Alternative names

      Solute carrier organic anion transporter family member 2B1, Organic anion transporter B, Organic anion transporter polypeptide-related protein 2, Solute carrier family 21 member 9, OATP-B, OATP-RP2, OATPRP2, SLCO2B1, KIAA0880, OATP2B1, OATPB, SLC21A9

      Recommended products

      1. Loading...
      2. Loading...
      3. Loading...
      4. Loading...

      Rabbit Recombinant Monoclonal SLCO2B1/OATP2B1 antibody. Carrier free. Suitable for WB and reacts with Human samples.

      Alternative names

      Solute carrier organic anion transporter family member 2B1, Organic anion transporter B, Organic anion transporter polypeptide-related protein 2, Solute carrier family 21 member 9, OATP-B, OATP-RP2, OATPRP2, SLCO2B1, KIAA0880, OATP2B1, OATPB, SLC21A9

      Key facts

      Isotype

      IgG

      Form

      Liquid

      Clonality

      Monoclonal

      Immunogen
      • The exact immunogen used to generate this antibody is proprietary information.
      Carrier free

      Yes

      Clone number

      EPR22212-37

      Purification technique

      Affinity purification Protein A

      Concentration
      Loading...

      Storage

      Shipped at conditions

      Blue Ice

      Appropriate long-term storage conditions

      +4°C

      Storage information

      Do Not Freeze

      Notes

      ab245829 is the carrier-free version of Anti-SLCO2B1/OATP2B1 antibody [EPR22212-37] ab245246.

      Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

      This product is a recombinant monoclonal antibody, which offers several advantages including:

      • - High batch-to-batch consistency and reproducibility
      • - Improved sensitivity and specificity
      • - Long-term security of supply
      • - Animal-free batch production

      For more information, read more on recombinant antibodies.

      Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. The carrier-free buffer and high concentration allow for increased conjugation efficiency.

      This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

      Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

      This product is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar® is a trademark of Fluidigm Canada Inc.

      Supplementary info

      Activity summary

      The SLCO2B1 also known as OATP2B1 is a member of the organic anion transporting polypeptides family. It functions as a transporter responsible for mediating the uptake of various drugs hormones and other organic compounds. This protein has a molecular mass of about 80 kDa. SLCO2B1 is primarily expressed in the human intestine and liver with significant presence in the brain lung and placenta. It plays a role in the absorption and clearance of pharmacologically relevant compounds.

      Biological function summary

      SLCO2B1 regulates the transport of endogenous and exogenous substrates across cell membranes. It does not form part of a larger protein complex but interacts with many substrates such as steroid hormones and therapeutic agents. SLCO2B1 influences how drugs are distributed and eliminated affecting the pharmacokinetics and bioavailability in tissues where it is expressed.

      Pathways

      SLCO2B1 integrates into processes related to drug metabolism and transport. It is important in the absorption and elimination phases within the pharmacokinetic pathway and has a role in the metabolism of steroid hormones. In this context SLCO2B1 cooperates with other transporters and metabolizing enzymes including cytochrome P450s to control the intracellular concentration of various substances.

      Associated diseases and disorders

      SLCO2B1 plays a role in influencing drug efficacy and toxicity impacting personalized medicine approaches for individuals with specific genetic transporter variants. SLCO2B1 has implications in cardiovascular diseases related to the pharmacological metabolism of drugs affecting heart rhythm. Additionally its function in hormone regulation connects it with metabolic disorders. In these diseases SLCO2B1 interacts with proteins like MDR1 which also impact drug transport and resistance.

      Product promise

      We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.

      In the unlikely event of one of our products not working as expected, you are covered by our product promise.

      Full details and terms and conditions can be found here:
      Terms & Conditions.

      1 product image

      • Western blot - Anti-SLCO2B1/OATP2B1 antibody [EPR22212-37] - BSA and Azide free (ab245829), expandable thumbnail

        Western blot - Anti-SLCO2B1/OATP2B1 antibody [EPR22212-37] - BSA and Azide free (ab245829)

        Exposure time : Lane 1: 3 seconds; Lane 2: 37 seconds.

        Blocking/Dilution buffer: 5% NFDM/TBST.

        The expression profile/ molecular weight observed is consistent with what has been described in the literature (PMID:11159893; PMID:16357150; PMID:17020956).

        This data was developed using the same antibody clone in a different buffer formulation containing PBS, BSA, glycerol, and sodium azide (Anti-SLCO2B1/OATP2B1 antibody [EPR22212-37] ab245246).

        All lanes: Western blot - Anti-SLCO2B1/OATP2B1 antibody [EPR22212-37] (Anti-SLCO2B1/OATP2B1 antibody [EPR22212-37] ab245246) at 1/1000 dilution

        Lane 1: Human placenta tissue lysate at 20 µg

        Lane 2: Human liver tissue lysate at 20 µg

        Secondary

        All lanes: Western blot - VeriBlot for IP Detection Reagent (HRP) (VeriBlot for IP Detection Reagent (HRP) ab131366) at 1/1000 dilution

        Predicted band size: 77 kDa

        Observed band size: 85 kDa

      Downloads

      Product protocols

      For this product, it's our understanding that no specific protocols are required. You can:

      Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

      For licensing inquiries, please contact partnerships@abcam.com