Anti-SLFN14 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

SLFN14 also known as Schlafen family member 14 is a protein with a molecular weight of approximately 100 kDa. It is mainly found in the cytoplasm with high expression in hematopoietic tissues such as the spleen. Its mechanical role involves nucleotide hydrolysis and regulatory effects on protein synthesis by interacting with ribosomes. This action modulates translation processes controlling the production of certain proteins.

Biological function summary

SLFN14 influences cell proliferation and differentiation. It associates and functions within complexes that regulate immune responses and cellular growth. By modulating ribosomal dynamics it directly impacts the synthesis of proteins essential for maintaining homeostasis in rapidly dividing cells such as those in the immune system.

Pathways

SLFN14 exerts influence on the immune response and cell cycle regulation pathways. It interacts with proteins involved in the innate immune response like IFN-inducible proteins facilitating adaptations to immunogenic stimuli. Its function ties into cell cycle regulation providing checkpoints that ensure genomic stability primarily through interactions with cyclins and cyclin-dependent kinases that mediate cell progression.

Associated diseases and disorders

SLFN14 mutations relate to thrombocytopenia and bone marrow failure syndromes. Abnormalities in SLFN14 can disrupt platelet production leading to bleeding disorders. Its interaction with proteins like GATA binding protein 1 (GATA1) underlines its role in these conditions where faulty regulation of hematopoiesis contributes to the pathophysiology. Researchers continue to study SLFN14's exact mechanism in these diseases to develop targeted therapeutic strategies.