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AB254806

Anti-SLFN14 antibody

5

(1 Review)

|

(2 Publications)

Rabbit Polyclonal SLFN14 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Protein SLFN14 aa 100-250.

View Alternative Names

Protein SLFN14, SLFN14

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLFN14 antibody (AB254806)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLFN14 antibody (AB254806)

Paraffin-embedded human cerebral cortex tissue stained for SLFN14 using ab254806 at 1/50 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Protein SLFN14 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.

P0C7P3

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AB129153

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HMGA1 antibody [EPR7839] (AB129153)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLFN14 also known as Schlafen family member 14 is a protein with a molecular weight of approximately 100 kDa. It is mainly found in the cytoplasm with high expression in hematopoietic tissues such as the spleen. Its mechanical role involves nucleotide hydrolysis and regulatory effects on protein synthesis by interacting with ribosomes. This action modulates translation processes controlling the production of certain proteins.
Biological function summary

SLFN14 influences cell proliferation and differentiation. It associates and functions within complexes that regulate immune responses and cellular growth. By modulating ribosomal dynamics it directly impacts the synthesis of proteins essential for maintaining homeostasis in rapidly dividing cells such as those in the immune system.

Pathways

SLFN14 exerts influence on the immune response and cell cycle regulation pathways. It interacts with proteins involved in the innate immune response like IFN-inducible proteins facilitating adaptations to immunogenic stimuli. Its function ties into cell cycle regulation providing checkpoints that ensure genomic stability primarily through interactions with cyclins and cyclin-dependent kinases that mediate cell progression.

SLFN14 mutations relate to thrombocytopenia and bone marrow failure syndromes. Abnormalities in SLFN14 can disrupt platelet production leading to bleeding disorders. Its interaction with proteins like GATA binding protein 1 (GATA1) underlines its role in these conditions where faulty regulation of hematopoiesis contributes to the pathophysiology. Researchers continue to study SLFN14's exact mechanism in these diseases to develop targeted therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Protein SLFN14. Shows no ribosome-associated and endoribonuclease activities.. C-terminally truncated SLFN14 endoribonuclease. Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs (PubMed : 25996083). May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs (Probable). Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner (By similarity). Involved in correct maturation of megakaryocytes and especially important for proplatelet extension.
See full target information Protein SLFN14
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Viruses 16: PubMed38675845

2024

Schlafen14 Impairs HIV-1 Expression in a Codon Usage-Dependent Manner.

Applications

Unspecified application

Species

Unspecified reactive species

Carlos Valenzuela,Sergio Saucedo,Manuel Llano

Molecular medicine reports 24: PubMed34581421

2021

RHBDD1 promotes proliferation, migration, invasion and EMT in renal cell carcinoma via the EGFR/AKT signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Mingyang Li,Licheng Cai,Xingyuan Wang,Yipeng Yu,Wengang Jian,Guochang Bao,Zhiming Gao,Junsheng Guo,Jian Zhang,Chunsheng Li,Cheng Zhang
View all publications
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Product promise

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