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AB198726

Anti-Slit3 antibody

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(3 Publications)

Rabbit Polyclonal SLIT3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human SLIT3.

View Alternative Names

KIAA0814, MEGF5, SLIL2, UNQ691/PRO1336, SLIT3, Slit homolog 3 protein, Slit-3, Multiple epidermal growth factor-like domains protein 5, Multiple EGF-like domains protein 5

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Slit3 antibody (AB198726)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Slit3 antibody (AB198726)

Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling Slit3 with ab198726 at 1/30 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Slit3 antibody (AB198726)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Slit3 antibody (AB198726)

Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue labeling Slit3 with ab198726 at 1/30 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human SLIT3. The exact immunogen used to generate this antibody is proprietary information.

O75094

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/25 - 1/100", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Slit3 also known as Slit Homolog 3 is a secreted protein encoded by the SLIT3 gene. It belongs to the Slit family of proteins and has a mass of approximately 160 kDa. These proteins typically have a leucine-rich domain and immunoglobulin-like repeats. Slit3 is expressed in various tissues including the heart lung and kidney but shows highest expression in the fetal lung. It operates in the extracellular space where it interacts with cell surface receptors to relay information essential for cellular functions.
Biological function summary

Slit3 regulates cellular migration and axon guidance by binding to Roundabout (Robo) receptors. This interaction plays a critical role in neuronal development and vascularization processes. In addition Slit3 can influence endothelial cell behavior and is a part of the axon guidance complex. By contributing to angiogenesis and neural patterning Slit3 impacts both developmental and repair mechanisms within the organism.

Pathways

The Slit3 protein participates in the axon guidance and angiogenesis signaling pathways. Slit3 interacts with Robo receptors to mediate cellular repulsion and navigation of the growth cones influencing nervous system architecture. The protein is closely related to other Slit family members particularly Slit1 and Slit2 which share similar roles in regulating guidance cues and vascular formation ensuring proper tissue development and injury response.

Disruptive mutations or altered expression of Slit3 have been linked to congenital diaphragmatic hernias and tumorigenesis. Congenital diaphragmatic hernia a defect that affects the diaphragm development connects to abnormal Slit3-mediated signaling that impacts tissue differentiation. Additionally changes in Slit3 expression might contribute to cancer progression by affecting tumor angiogenesis; this interaction involves proteins such as Robo1 and Robo4 making them potential targets in disease modulation.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.
See full target information SLIT3
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

PeerJ 11:e14850 PubMed36793891

2023

Abnormal expression of induces intravillous vascularization dysplasia in ectopic pregnancy.

Applications

Unspecified application

Species

Unspecified reactive species

Qian Zhu,Xiaoya Zhao,Duo Zhang,Wei Xia,Jian Zhang

Oral diseases 26:182-192 PubMed31696592

2019

Gingival crevicular fluid levels of SLIT3 are increased in periodontal disease.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Zhong,Youmei Peng,Erli Yue,Bin Huang,Wei Zhang,Zhe Zhao,Jinhua Jiang,Qingduan Wang,Hongyu Zhao

Nature medicine 24:823-833 PubMed29785024

2018

Targeting skeletal endothelium to ameliorate bone loss.

Applications

Unspecified application

Species

Unspecified reactive species

Ren Xu,Alisha Yallowitz,An Qin,Zhuhao Wu,Dong Yeon Shin,Jung-Min Kim,Shawon Debnath,Gang Ji,Mathias P Bostrom,Xu Yang,Chao Zhang,Han Dong,Pouneh Kermani,Sarfaraz Lalani,Na Li,Yifang Liu,Michael G Poulos,Amanda Wach,Yi Zhang,Kazuki Inoue,Annarita Di Lorenzo,Baohong Zhao,Jason M Butler,Jae-Hyuck Shim,Laurie H Glimcher,Matthew B Greenblatt
View all publications
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Product promise

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