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AB67238

Anti-Slitrk1 antibody

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(1 Publication)

Rabbit Polyclonal Slitrk1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SLITRK1.

View Alternative Names

KIAA1910, LRRC12, UNQ233/PRO266, SLITRK1, SLIT and NTRK-like protein 1, Leucine-rich repeat-containing protein 12

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Slitrk1 antibody (AB67238)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Slitrk1 antibody (AB67238)

Immunohistochemistry of Slitrk1 in Human brain tissue with Slitrk1 antibody at 2.5 μg/mL.

Immunocytochemistry/ Immunofluorescence - Anti-Slitrk1 antibody (AB67238)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Slitrk1 antibody (AB67238)

Immunofluorescence of Slitrk1 in Human brain tissue with ab67238 at 20 ug/mL.

Western blot - Anti-Slitrk1 antibody (AB67238)
  • WB

Unknown

Western blot - Anti-Slitrk1 antibody (AB67238)

Lane 1:

Western blot - Anti-Slitrk1 antibody (ab67238) at 1 µg/mL

Lane 2:

Western blot - Anti-Slitrk1 antibody (ab67238) at 2 µg/mL

All lanes:

human brain tissue lysate at 15 µg

Predicted band size: 78 kDa

Observed band size: 60 kDa,88 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Synthetic Peptide within Human SLITRK1. The exact immunogen used to generate this antibody is proprietary information.

Q96PX8

Specificity

This antibody is predicted to have no cross-reactivity to other Slitrk proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Slitrk1 also known as SLIT and NTRK-like protein 1 is a transmembrane protein with a mass of approximately 95 kDa. It functions mechanically by interacting with neuronal cells to influence axonogenesis and synaptogenesis. Slitrk1 has a role in the nervous system where it is primarily expressed particularly in the brain. Its structure includes leucine-rich repeat (LRR) domains facilitating its interactions with the cellular environment and other molecules.
Biological function summary

Slitrk1 influences neural development and synapse formation playing a role in the regulation of synaptic strength. It may interact with the receptor protein tyrosine phosphatase sigma (PTPσ) forming a receptor-ligand pair critical for its function in neural contexts. This interaction contributes to promoting proper neuronal connections and maintaining synaptic plasticity which is essential for cognitive processes.

Pathways

The role Slitrk1 plays in neural development connects it to the neurotrophic signaling pathway. This pathway influences neuron survival development and function. Slitrk1 is also linked with the semaphorin-plexin signaling pathway which guides axon guidance and neuronal positioning. Proteins like neurotrophin receptor TrkC and plexins may relate to Slitrk1 within these pathways influencing its downstream signaling effects.

Genetic mutations in Slitrk1 have been associated with Tourette syndrome and trichotillomania. These conditions are neurodevelopmental indicating Slitrk1’s importance in the nervous system's proper function. Slitrk1's association with PTPσ in these disorders shows its potential as a therapeutic target as PTPσ's pathway disruption could contribute to the symptoms observed in these disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed : 27273464, PubMed : 27812321). Enhances neuronal dendrite outgrowth (PubMed : 16224024, PubMed : 19640509).
See full target information SLITRK1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

PloS one 6:e23132 PubMed21829704

2011

TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding.

Applications

Unspecified application

Species

Unspecified reactive species

Masakiyo Sakaguchi,Hitoshi Murata,Ken-ichi Yamamoto,Tomoyuki Ono,Yoshihiko Sakaguchi,Akira Motoyama,Toshihiko Hibino,Ken Kataoka,Nam-ho Huh
View all publications
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Product promise

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