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AB115594

Anti-SLITRK2 antibody

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(1 Publication)

Rabbit Polyclonal SLITRK2 antibody. Suitable for IHC-P, WB and reacts with Human, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SLITRK2.

View Alternative Names

CXorf2, KIAA1854, SLITL1, UNQ9197/PRO34756, SLITRK2, SLIT and NTRK-like protein 2

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLITRK2 antibody (AB115594)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLITRK2 antibody (AB115594)

ab115594, at 5 µg/ml, staining SLITRK2 in formalin fixed, paraffin embedded Human brain cerebellum by Immunohistochemistry. After incubation with the primary antibody, slides were incubated with biotinylated goat anti-rabbit secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Western blot - Anti-SLITRK2 antibody (AB115594)
  • WB

Unknown

Western blot - Anti-SLITRK2 antibody (AB115594)

Lane 1:

Western blot - Anti-SLITRK2 antibody (ab115594) at 1 µg/mL

Lane 2:

Western blot - Anti-SLITRK2 antibody (ab115594) at 2 µg/mL

All lanes:

Rat brain tissue lysate

Predicted band size: 95 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human SLITRK2. The exact immunogen used to generate this antibody is proprietary information.

Q9H156

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLITRK2 also known as Slit and Trk-like family member 2 is a protein with a molecular weight of approximately 104 kDa. Expressed mainly in the central nervous system especially in the brain this protein includes six leucine-rich repeat domains. It plays a significant role in neural development by promoting neurite outgrowth and regulating synapse formation. SLITRK2 is a transmembrane protein influencing cell adhesion processes integral to nerve cell differentiation and connectivity.
Biological function summary

SLITRK2 contributes to synaptic connectivity and neuron-to-neuron communication. It is part of a family of proteins with structural similarities to Trk neurotrophin receptors which are key in maintaining neural networks. However SLITRK2 acts independently of classical neurotrophic signaling pathways. The protein's design lets it interact with other synaptic proteins supporting the appropriate development of neuron circuits essential for cognitive functions.

Pathways

SLITRK2 is involved in the regulation of synaptic strength and plasticity. It is associated with the synaptic adhesion network pathway interacting closely with proteins like LAR-RPTP and PSD-95. SLITRK2 modulates these pathways to influence synaptic remodeling and neurotransmission strength which are central aspects of synaptic function and plasticity. Although its pathways differ from classical neurotrophic signaling SLITRK2's role in neural connectivity is linked in scope and impact.

Research links SLITRK2 to neurodevelopmental disorders such as schizophrenia. Abnormalities in SLITRK2 expression and function can lead to disruptions in neural circuitry potentially contributing to cognitive deficits observed in such conditions. Additionally associations with autism spectrum disorders have been observed implicating SLITRK2 in abnormal synaptic development. The protein interacts with others like neurexins and neuroligins significant in these disorders playing a role in disrupted synaptic adhesion and signaling attributed to pathological states in neurodevelopmental contexts.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed : 27273464, PubMed : 27812321, PubMed : 35840571). Suppresses neurite outgrowth (By similarity). Involved in the negative regulation of NTRK2 (PubMed : 35840571).
See full target information SLITRK2
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

PloS one 10:e0118165 PubMed25680105

2015

Putative porcine embryonic stem cell lines derived from aggregated four-celled cloned embryos produced by oocyte bisection cloning.

Applications

Unspecified application

Species

Unspecified reactive species

Chawalit Siriboon,Yu-Hsuan Lin,Michel Kere,Chun-Da Chen,Lih-Ren Chen,Chien-Hong Chen,Ching-Fu Tu,Neng-Wen Lo,Jyh-Cherng Ju
View all publications
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Product promise

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