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AB67312

Anti-SLITRK6 antibody

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(1 Publication)

Rabbit Polyclonal SLITRK6 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SLIT and NTRK-like protein 6.

View Alternative Names

SLIT and NTRK-like protein 6, SLITRK6

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-SLITRK6 antibody (AB67312)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-SLITRK6 antibody (AB67312)

Immunofluorescence of Slitrk6 in Human Brain cells using ab67312 at 20 ug/ml.

Western blot - Anti-SLITRK6 antibody (AB67312)
  • WB

Unknown

Western blot - Anti-SLITRK6 antibody (AB67312)

Lane 1:

Western blot - Anti-SLITRK6 antibody (ab67312) at 0.5 µg/mL

Lane 2:

Western blot - Anti-SLITRK6 antibody (ab67312) at 1 µg/mL

All lanes:

SK-N-SH cell lysate at 15 µg

Predicted band size: 95 kDa

Observed band size: 55 kDa,95 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, WB

applications

Immunogen

Synthetic Peptide within Human SLIT and NTRK-like protein 6. The exact immunogen used to generate this antibody is proprietary information.

Q9H5Y7

Specificity

This antibody is predicted to have no cross-reactivity to other Slitrk proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLITRK6 also known as SLIT and NTRK-like family protein 6 is a transmembrane protein weighing approximately 103 kDa. It belongs to the SLITRK family and is characterized by containing leucine-rich repeat (LRR) domains. SLITRK6 is mainly expressed in the nervous system particularly in the retina and specific regions of the brain such as the olfactory bulb and limbic system. In addition it shows expression in non-neuronal tissues including the kidney and prostate tissue demonstrating a diverse tissue distribution.
Biological function summary

SLITRK6 plays a critical role in neural development and cell signaling processes. It participates in neurite outgrowth regulation impacting both neuronal differentiation and synaptic connectivity. SLITRK6 does not function in isolation but may form complexes with other proteins contributing to axon guidance and synaptic maintenance. The protein's involvement in cell signaling extends its influence on tissue organization and stability.

Pathways

SLITRK6 interacts with neurotrophin pathways impacting neural growth and survival. Specifically it modulates pathways involving the NTRK family of receptors which are central to neurotrophic signaling. SLITRK6 is related to the SLIT and ROBO proteins through shared roles in axonal pathfinding and synapse formation. The cross-talk with neurotrophic pathways suggests SLITRK6 as a mediator in neuronal network formation and structural integrity.

SLITRK6 has been linked to sensorineural hearing loss and psychiatric conditions such as schizophrenia. Its connection to neurotrophic pathways implicates an association with cognitive and sensory disorders. In some cancers it also appears to interact with other molecules affecting tumor growth and resistance for example interacting with NTRK family members in cancer pathways. Elucidating SLITRK6's role furthers understanding in neurologic disorders and potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulator of neurite outgrowth required for normal hearing and vision.
See full target information SLIT and NTRK-like protein 6
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer letters 297:198-206 PubMed20547442

2010

Novel target genes responsive to the anti-growth activity of triptolide in endometrial and ovarian cancer cells.

Applications

WB

Species

Human

Haili Li,Noriyuki Takai,Akitoshi Yuge,Yuichi Furukawa,Akitoshi Tsuno,Yoshiyuki Tsukamoto,Shigi Kong,Masatsugu Moriyama,Hisashi Narahara
View all publications
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Product promise

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