Rabbit Polyclonal SLITRK6 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SLIT and NTRK-like protein 6.
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- Cancer letters 297:198-2062010Novel target genes responsive to the anti-growth activity of triptolide in endometrial and ovarian cancer cells.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human SLIT and NTRK-like protein 6. The exact immunogen used to generate this antibody is proprietary information. Database link Q9H5Y7
Reactivity data
Select an application| WB | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Predicted | Predicted |
| Rat | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.50000-1.00000 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 20 µg/mL | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Associated Products
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2 products for Alternative Product
Target data
Function
Regulator of neurite outgrowth required for normal hearing and vision.
Alternative names
SLIT and NTRK-like protein 6, SLITRK6
Recommended products
Rabbit Polyclonal SLITRK6 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SLIT and NTRK-like protein 6.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human SLIT and NTRK-like protein 6. The exact immunogen used to generate this antibody is proprietary information. Database link Q9H5Y7
- Purification technique
- Affinity purification Immunogen
- Specificity
This antibody is predicted to have no cross-reactivity to other Slitrk proteins.
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- +4°C
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SLITRK6 also known as SLIT and NTRK-like family protein 6 is a transmembrane protein weighing approximately 103 kDa. It belongs to the SLITRK family and is characterized by containing leucine-rich repeat (LRR) domains. SLITRK6 is mainly expressed in the nervous system particularly in the retina and specific regions of the brain such as the olfactory bulb and limbic system. In addition it shows expression in non-neuronal tissues including the kidney and prostate tissue demonstrating a diverse tissue distribution.
- Biological function summary
SLITRK6 plays a critical role in neural development and cell signaling processes. It participates in neurite outgrowth regulation impacting both neuronal differentiation and synaptic connectivity. SLITRK6 does not function in isolation but may form complexes with other proteins contributing to axon guidance and synaptic maintenance. The protein's involvement in cell signaling extends its influence on tissue organization and stability.
- Pathways
SLITRK6 interacts with neurotrophin pathways impacting neural growth and survival. Specifically it modulates pathways involving the NTRK family of receptors which are central to neurotrophic signaling. SLITRK6 is related to the SLIT and ROBO proteins through shared roles in axonal pathfinding and synapse formation. The cross-talk with neurotrophic pathways suggests SLITRK6 as a mediator in neuronal network formation and structural integrity.
- Associated diseases and disorders
SLITRK6 has been linked to sensorineural hearing loss and psychiatric conditions such as schizophrenia. Its connection to neurotrophic pathways implicates an association with cognitive and sensory disorders. In some cancers it also appears to interact with other molecules affecting tumor growth and resistance for example interacting with NTRK family members in cancer pathways. Elucidating SLITRK6's role furthers understanding in neurologic disorders and potential therapeutic targets.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-SLITRK6 antibody (ab67312)
Lane 1: Western blot - Anti-SLITRK6 antibody (ab67312) at 0.5 µg/mL
Lane 2: Western blot - Anti-SLITRK6 antibody (ab67312) at 1 µg/mL
All lanes: SK-N-SH cell lysate at 15 µg
Predicted band size: 95 kDa
Observed band size: 55 kDa, 95 kDa
Immunocytochemistry/ Immunofluorescence - Anti-SLITRK6 antibody (ab67312)
Immunofluorescence of Slitrk6 in Human Brain cells using ab67312 at 20 ug/ml.
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