JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB243383

Anti-SLMAP antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal SLMAP antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLMAP aa 1-150.

View Alternative Names

KIAA1601, SLAP, UNQ1847/PRO3577, SLMAP, Sarcolemmal membrane-associated protein, Sarcolemmal-associated protein

6 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLMAP antibody (AB243383)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLMAP antibody (AB243383)

Formalin-fixed, paraffin-embedded human smooth muscle tissue stained for SLMAP with ab243383 at a 1 : 200 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-SLMAP antibody (AB243383)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SLMAP antibody (AB243383)

Immunocytochemistry/Immunofluorescence analysis of A431 (Human epidermoid carcinoma cell line) cells labeling SLMAP using ab243383 at 4 μg/ml (green). Nuclear probe is visualized in blue, microtubules in red.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLMAP antibody (AB243383)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLMAP antibody (AB243383)

Formalin-fixed, paraffin-embedded human testis tissue stained for SLMAP with ab243383 at a 1 : 200 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLMAP antibody (AB243383)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SLMAP antibody (AB243383)

Formalin-fixed, paraffin-embedded human liver tissue stained for SLMAP with ab243383 at a 1 : 200 dilution in immunohistochemical analysis.

Western blot - Anti-SLMAP antibody (AB243383)
  • WB

Supplier Data

Western blot - Anti-SLMAP antibody (AB243383)

All lanes:

Western blot - Anti-SLMAP antibody (ab243383) at 0.4 µg/mL

Lane 1:

RT4 (Human urinary bladder cancer cell line) cell lysate

Lane 2:

U-251 MG (Human brain glioma cell line) cell lysate

Lane 3:

A431 (Human epidermoid carcinoma cell line) cell lysate

Lane 4:

Human liver lysate

Lane 5:

Human tonsil lysate

Predicted band size: 95 kDa

false

Western blot - Anti-SLMAP antibody (AB243383)
  • WB

Supplier Data

Western blot - Anti-SLMAP antibody (AB243383)

All lanes:

Western blot - Anti-SLMAP antibody (ab243383) at 0.4 µg/mL

Lane 1:

NIH/3T3 (Mouse embryo fibroblast cell line) cell lysate

Lane 2:

NBT-II (Rat Wistar bladder tumor cell line) cell lysate

Predicted band size: 95 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human SLMAP aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q14BN4

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SLMAP also known as sarcolemmal membrane-associated protein is a protein of approximately 91 kDa in size. It plays a role in maintaining structure and stability in cells particularly in muscle tissues. The protein localizes primarily to membranes of the sarcolemma a structure associated with muscle cells. Although present in various tissues it shows higher expression within cardiac and skeletal muscles indicating its importance in these areas.
Biological function summary

SLMAP is involved in the organization of the cytoskeletal structure in muscular tissues. It interacts with ion channels and other membrane proteins forming part of a larger complex that stabilizes cellular membranes during muscle contraction and relaxation. SLMAP assists in modulating the activities of these channels impacting cellular excitability and signal transduction. Its role is critical for the integrity of muscle function ensuring proper mechanical and electrical responses in muscle fibers.

Pathways

SLMAP plays a role in the cellular signaling processes important for cardiac muscle homeostasis. It participates in the regulation of ion transport pathways interacting closely with proteins such as ion channel subunits. SLMAP is also associated with muscle contraction pathways where it impacts signaling mechanisms that coordinate muscle function. These interactions highlight its importance in pathways that ensure the efficient functioning of muscle tissues.

Problems with SLMAP expression or function relate to cardiac disorders including cardiomyopathy and arrhythmias. These conditions can stem from disruptions in cardiac ion channel functions a process in which SLMAP plays a critical role. Additionally abnormal SLMAP function may connect to muscular dystrophies where it is part of a network of proteins involving dystrophin that supports muscle integrity. These associations underline SLMAP’s involvement in maintaining muscle health suggesting its potential as a target for therapeutic intervention in relevant diseases.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1 : SLMAP)STRIPAK complex (PubMed : 29063833, PubMed : 30622739). The (SIKE1 : SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (PubMed : 29063833, PubMed : 30622739). May play a role during myoblast fusion (By similarity).
See full target information SLMAP
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer medicine 12:10738-10754 PubMed36880364

2023

Sulfotransferase 1C2 promotes hepatocellular carcinoma progression by enhancing glycolysis and fatty acid metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Liya Jiang,Fang Xu,Chenglong Li,Ting Liu,Qianwei Zhao,Yixian Liu,Ying Zhao,Yamei Li,Zhendong Zhang,Xiaolei Tang,Jintao Zhang
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Primary Antibodies

AB216508

Anti-KIBRA antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KIBRA antibody (AB216508)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB15580

Anti-Ki67 antibody

BOND RX™ Validated|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody (AB15580)

  • 5
  • 230
Primary Antibodies

AB52641

Anti-STK3/MST-2 antibody [EP1466Y]

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-STK3/MST-2 antibody [EP1466Y] (AB52641)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com