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AB234743

Anti-Small integral membrane protein 1 antibody

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(1 Publication)

Rabbit Polyclonal Small integral membrane protein 1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SMIM1 aa 1-50.

View Alternative Names

Small integral membrane protein 1, Vel blood group antigen, SMIM1

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-Small integral membrane protein 1 antibody (AB234743)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Small integral membrane protein 1 antibody (AB234743)

HepG2 (human liver hepatocellular carcinoma cell line) cells labelling Small integral membrane protein 1 (green) using ab234743 at 1/100 dilution. The secondary antibody is Alexa Fluor® 488-congugated Goat Anti-Rabbit IgG(H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Small integral membrane protein 1 antibody (AB234743)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Small integral membrane protein 1 antibody (AB234743)

Paraffin-embedded human testis tissue stained for Small integral membrane protein 1 using ab234743 at 1/100 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SMIM1 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

B2RUZ4

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Small integral membrane protein 1 (SMIM1) also known as Vel blood group antigen is a component of erythrocyte membranes. This protein has a molecular mass of about 9 kDa. While its expression is most observed in red blood cells SMIM1 may also exhibit presence in other tissue types though less extensively studied. SMIM1 spans the membrane indicating its integral role as a transporter or a facilitator for intercellular communications.
Biological function summary

The small protein influences the surface characteristics of erythrocytes. It impacts cell membrane stability and arrangement of other proteins in the lipid bilayer. While not forming large complexes itself SMIM1 interacts with various membrane components to preserve membrane integrity. Its presence contributes to erythrocyte shape which is critical for optimal blood flow and oxygen transport.

Pathways

SMIM1 participates in pathways related to erythrocyte development and function. It relates closely to the erythroblastic island a niche important for red blood cell maturation. Through its interactions SMIM1 associates with proteins like band 3 and glycophorin which are involved in maintaining cell structure and transport mechanisms. These associations emphasize SMIM1's involvement in the orchestration of red blood cell stability and viability.

Aberrant SMIM1 expression or mutations link to transfusion-related complications and blood-group incompatibility. Vel-negative blood group individuals lack SMIM1 leading to transfusion challenges. SMIM1 mutations can relate to disorders like anemia where abnormal erythrocyte morphology impairs function. These conditions often involve other membrane proteins such as spectrin highlighting SMIM1's role within a network important for erythrocyte health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulator of red blood cell formation.
See full target information SMIM1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cellular neuroscience 15:662035 PubMed34025359

2021

Integrative Cell Type-Specific Multi-Omics Approaches Reveal Impaired Programs of Glial Cell Differentiation in Mouse Culture Models of DM1.

Applications

Unspecified application

Species

Unspecified reactive species

Anchel González-Barriga,Louison Lallemant,Diana M Dincã,Sandra O Braz,Hélène Polvèche,Paul Magneron,Cédric Pionneau,Aline Huguet-Lachon,Jean-Baptiste Claude,Cerina Chhuon,Ida Chiara Guerrera,Cyril F Bourgeois,Didier Auboeuf,Geneviève Gourdon,Mário Gomes-Pereira
View all publications
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Product promise

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