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AB204982

Anti-Small leucine rich protein 1 antibody

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(1 Publication)

Rabbit Polyclonal Small leucine rich protein 1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SMLR1 aa 50 to C-terminus.

View Alternative Names

Small leucine-rich protein 1, SMLR1

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Small leucine rich protein 1 antibody (AB204982)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Small leucine rich protein 1 antibody (AB204982)

Immunohistochemical analysis of paraffin-embedded Human urinary bladder tissue labeling Small leucine rich protein 1 with ab204982 at 1/50 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SMLR1 aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

H3BR10

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Small leucine rich protein 1 (SLRP1) also known as osteoglycin or mimecan is a small proteoglycan with a molecular mass of approximately 36 kDa. SLRP1 contains leucine-rich repeats which are important for its function. It is predominantly found in the extracellular matrix of connective tissues including cartilage skin and bone where it plays a part in matrix organization. The expression of this protein can vary between different types of tissues highlighting its diverse roles in various physiological environments.
Biological function summary

Small leucine rich proteins such as SLRP1 are involved in the regulation of collagen fibrillogenesis. They interact directly with collagen fibrils and influence fiber size and spacing. SLRP1 is also known to impact cellular proliferation and differentiation which is partly due to its interaction with various growth factor receptors. This protein does not commonly form part of large stable complexes but may transiently associate with other extracellular matrix components during tissue development and repair.

Pathways

Several studies link small leucine rich proteins including SLRP1 to the transforming growth factor-beta (TGF-β) signaling pathway. TGF-β is important for controlling cell growth and repair mechanisms and SLRP1 can modulate its activity by influencing its bioavailability and receptor interactions. Additionally SLRP1 may have roles in the Wnt signaling pathway connected through indirect mechanisms related to extracellular matrix stability further interacting with other structural proteins in extracellular environments.

Malfunction or altered expression of SLRP1 associates primarily with musculoskeletal disorders such as osteoarthritis. Changes in the extracellular matrix composition and collagen interaction can disrupt tissue integrity contributing to disease progression. SLRP1 also associates with certain cardiovascular diseases where alterations in extracellular matrix components affect vascular function. In some cases the protein interacts with matrix metalloproteinases which degrade matrix proteins and contribute to structural changes in diseased tissues.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information SMLR1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Clinical epigenetics 12:173 PubMed33203470

2020

The tumor suppressor Zinc finger protein 471 suppresses breast cancer growth and metastasis through inhibiting AKT and Wnt/β-catenin signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Chunfang Tao,Juan Luo,Jun Tang,Danfeng Zhou,Shujun Feng,Zhu Qiu,Thomas C Putti,Tingxiu Xiang,Qiao Tao,Lili Li,Guosheng Ren
View all publications
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Product promise

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