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AB53309

Anti-Smallpox B5R antibody

1

(1 Review)

|

(1 Publication)

Rabbit Polyclonal Smallpox B5R antibody. Suitable for WB and reacts with Recombinant fragment - Variola virus samples. Cited in 1 publication.
1 Images
Western blot - Anti-Smallpox B5R antibody (AB53309)
  • WB

Unknown

Western blot - Anti-Smallpox B5R antibody (AB53309)

60kDa band is a dimerized peptide carrier.

All lanes:

Western blot - Anti-Smallpox B5R antibody (ab53309) at 0.1 µg/mL

Lane 1:

recombinant fusion protein containing amino acids 180-194

Lane 2:

fusion partner only

Predicted band size: 64 kDa

Observed band size: 30 kDa,60 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Variola virus

Applications

WB

applications

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Primary Antibodies

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Secondary Antibodies

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Primary Antibodies

AB312854

Anti-Vaccinia Virus antibody [EPR28236-80]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Vaccinia Virus antibody [EPR28236-80] (AB312854)

  • 0
  • 0
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Recombinant fragment - Variola virus": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-1 µg/mL", "WB-species-notes": "<p></p>" }, "Variola virus": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Storage buffer
Preservative: 0.05% Sodium azide Constituents: PBS, 0.2% Gelatin
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The smallpox B5R protein often just referred to as B5R is a critical component in the life cycle of Orthopoxviruses including variola virus and monkeypox. This protein with a mass of around 42 kDa integrates into the membrane of the extracellular enveloped virus (EEV) form of these viruses. B5R facilitates the virus's ability to leave the host cell and spread to new cells. While there are no widely known alternate names for B5R it remains a significant target for neutralizing antibodies in the design of vaccines.
Biological function summary

B5R plays an important role in the egress and dissemination of the virus within the host. It is part of a larger protein complex responsible for forming the outer envelope of the virus which is necessary for the release of virus particles from infected cells. By aiding the fusion of viral and cellular membranes B5R enables the virus to evade the immune response and promote infection.

Pathways

B5R involves itself in viral replication and immune evasion mechanisms. It is essential in the viral egress pathway operating alongside proteins such as A33R and F13L. These proteins together contribute to the packaging and release of the virus from the host cell allowing it to infect neighboring cells efficiently. B5R through its function supports a seamless interaction within these pathways enhancing viral spread.

B5R has significant implications in the context of diseases caused by Orthopoxviruses namely smallpox and monkeypox. The B5R protein is linked with the virulence of these pathogens making it an important target for antiviral drug development and vaccine design. The protein interacts with immune modulatory pathways potentially working alongside other viral proteins like A36R to disrupt normal immune functions thereby exacerbating the pathogenicity of these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information Smallpox B5R

Alternative Names

B5R, EEV type I membrane glycoprotein, Smallpox
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Publications (1)

Recent publications for all applications. Explore the full listand refine your search

International journal of molecular medicine 42:988-997 PubMed29786109

2018

Engulfment of platelets delays endothelial cell aging via girdin and its phosphorylation.

Applications

Unspecified application

Species

Unspecified reactive species

Yong Lan,Yongjun Li,Dajun Li,Peng Li,Jiyang Wang,Yongpeng Diao,Guodong Ye,Yangfang Li
View all publications
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Product promise

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