Anti-SMAP2 antibody [OTI9B6]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

SMAP2 also known as Stromal Membrane-Associated Protein 2 encodes a protein with an approximate mass of 45 kDa. This protein plays a role as a GTPase-activating protein for the ADP-ribosylation factor (ARF) family of GTPases. It regulates the ARF proteins by converting them from the active GTP-bound state to the inactive GDP-bound state. SMAP2 shows a widespread expression pattern in various tissues with detectable levels in organs such as the brain liver and kidney.

Biological function summary

The regulation of ARF proteins by SMAP2 impacts membrane trafficking and dynamics. It assists in the disassembly of coated vesicles a critical step for intracellular transport. Although SMAP2 does not form part of a well-defined protein complex itself its regulation of ARFs influences complexes involved in vesicular trafficking like the coatomer complexes. This activity ensures proper cellular transport and communication.

Pathways

The GTPase-activating function of SMAP2 integrates into the vesicular transport and Golgi apparatus-related pathways. SMAP2 activity is important in trafficking pathways where it impacts vesicle budding and uncoating processes. It functions alongside other proteins involved in these pathways such as ARF1 and COPI which coordinate in maintaining cellular homeostasis and protein sorting.

Associated diseases and disorders

SMAP2 has potential links to neurodegenerative diseases such as Alzheimer's disease and various types of cancer. Alterations in vesicular trafficking may contribute to the pathophysiology of these conditions. The interactions of SMAP2 with proteins like ARF1 are of interest as ARF1’s dysregulation has been noted in cancer cell proliferation and survival. Understanding SMAP2’s role could therefore offer insights into therapeutic targets for these diseases.