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AB96206

Anti-SMC1L2 antibody

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(2 Publications)

Rabbit Polyclonal SMC1L2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SMC1B aa 150-450.

View Alternative Names

SMC1L2, SMC1B, Structural maintenance of chromosomes protein 1B, SMC protein 1B, SMC-1-beta, SMC-1B

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SMC1L2 antibody (AB96206)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SMC1L2 antibody (AB96206)

Immunohistochemical analysis of paraffin-embedded SAS xenograft, using ab96206 at 1 : 500 dilution.

Western blot - Anti-SMC1L2 antibody (AB96206)
  • WB

Unknown

Western blot - Anti-SMC1L2 antibody (AB96206)

5% SDS PAGE

All lanes:

Western blot - Anti-SMC1L2 antibody (ab96206) at 1/1000 dilution

All lanes:

HeLa whole cell lysate at 30 µg

Predicted band size: 144 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SMC1B aa 150-450. The exact immunogen used to generate this antibody is proprietary information.

Q8NDV3

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SMC1L2 also known as Structural Maintenance of Chromosomes 1-Like 2 is a protein involved in important processes in cell division. It is a part of the cohesin complex a structure that regulates the cohesion of sister chromatids during cell division. SMC1L2 has a molecular mass of approximately 155 kDa. This protein is expressed in various tissues with notable expression in testis and other reproductive organs reflecting its involvement in meiotic cell division.
Biological function summary

This protein plays a significant role in ensuring the accurate segregation of chromosomes during both mitosis and meiosis. SMC1L2 is an important component of the cohesin complex interacting closely with other proteins like SMC3 RAD21 and STAG3. By holding sister chromatids together it helps maintain genomic stability and prevents aneuploidy which can lead to compromised cell function or cell death if not regulated properly.

Pathways

SMC1L2 functions in critical cellular mechanisms such as the cell cycle and DNA repair pathways. The protein contributes to the mitotic cell cycle particularly in the regulation of sister chromatid cohesion an essential checkpoint for proper cell cycle progression. Furthermore SMC1L2 involvement in the DNA damage response highlights its connection with proteins like ATM and ATR which act as sensors and mediators of DNA repair mechanisms following genotoxic stress.

SMC1L2 mutations or malfunctions can be associated with reproductive issues and chromosomal instability disorders. For instance defects in this protein can lead to male infertility due to its role in spermatogenesis. Moreover the protein’s dysfunction could contribute to cancer development by compromising genomic integrity. SMC1L2 may interact with altered p53 pathways as chromosomal stability is important in tumor suppression and prevention of cancerous cell growth.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity).
See full target information SMC1B
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Genome biology 23:70 PubMed35241136

2022

Meiosis-specific cohesin complexes display essential and distinct roles in mitotic embryonic stem cell chromosomes.

Applications

Unspecified application

Species

Unspecified reactive species

Eui-Hwan Choi,Seobin Yoon,Young Eun Koh,Tae Kyung Hong,Jeong Tae Do,Bum-Kyu Lee,Yoonsoo Hahn,Keun P Kim

Cancer biology & medicine 16:595-605 PubMed31565488

2019

A four-gene signature-derived risk score for glioblastoma: prospects for prognostic and response predictive analyses.

Applications

Unspecified application

Species

Unspecified reactive species

Mianfu Cao,Juan Cai,Ye Yuan,Yu Shi,Hong Wu,Qing Liu,Yueliang Yao,Lu Chen,Weiqi Dang,Xiang Zhang,Jingfang Xiao,Kaidi Yang,Zhicheng He,Xiaohong Yao,Yonghong Cui,Xia Zhang,Xiuwu Bian
View all publications
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