Rabbit Polyclonal SMC5 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Structural maintenance of chromosomes protein 5 aa 250-500.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Liquid
Polyclonal
WB | |
---|---|
Human | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
Select an associated product type
Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome (PubMed:26983541).
KIAA0594, SMC5L1, SMC5L1, KIAA0594, SMC5, Structural maintenance of chromosomes protein 5, SMC protein 5, SMC-5, hSMC5
Rabbit Polyclonal SMC5 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Structural maintenance of chromosomes protein 5 aa 250-500.
IgG
Rabbit
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Liquid
Polyclonal
Affinity purification Immunogen
Blue Ice
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
SMC5 also known as Structural Maintenance of Chromosomes 5 is a protein that plays a significant role in chromosome segregation and stability. It has a molecular mass of approximately 122 kDa. This protein is widely expressed in many tissues with high levels observed in the brain liver and lung. SMC5 is a part of the SMC protein family and functions in connection with SMC6 forming the SMC5/6 complex. This complex is necessary for DNA repair and recombination processes.
SMC5 influences the maintenance of genomic integrity during cell division. It is an essential component of the SMC5/6 complex which also includes non-SMC proteins like NSMCE1-4. The complex facilitates proper segregation of chromosomes by stabilizing replication forks and resolving DNA interlinkages. This mechanism is key in preventing genomic instability which can lead to diverse cellular dysfunctions.
SMC5 is involved in the DNA damage response and homologous recombination repair pathways. It interacts with proteins like RAD51 which plays a role in the repair of double-strand breaks through homologous recombination. These pathways ensure that damaged DNA is accurately repaired preventing erroneous sequences from propagating during subsequent cell divisions.
SMC5 has been linked to conditions such as cancer and Fanconi anemia. Mutations affecting the SMC5/6 complex can lead to defective DNA repair and accumulated genomic instability often observed in cancers. The complex's disruption also relates to Fanconi anemia a disorder that affects bone marrow function. There are associations with proteins like BRCA1 and FANCI both of which participate in the cellular response to DNA damage and repair highlighting the complex's medical relevance.
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5% SDS PAGE
All lanes: Western blot - Anti-SMC5 antibody (ab154103) at 1/500 dilution
All lanes: NT2D1 whole cell lysate at 30 µg
Predicted band size: 129 kDa
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