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AB227952

Anti-SMNDC1 antibody

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(1 Publication)

Rabbit Polyclonal SMNDC1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SMNDC1.

View Alternative Names

SMNR, SPF30, SMNDC1, Survival of motor neuron-related-splicing factor 30, 30 kDa splicing factor SMNrp, SMN-related protein, Survival motor neuron domain-containing protein 1

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SMNDC1 antibody (AB227952)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SMNDC1 antibody (AB227952)

Paraffin-embedded human lung cancer tissue stained for SMNDC1 using ab227952 at 1/500 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-SMNDC1 antibody (AB227952)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SMNDC1 antibody (AB227952)

Paraformaldehyde-fixed MCF7 (human breast adenocarcinoma cell line) cells stained for SMNDC1 (green) using ab227952 at 1/500 dilution in ICC/IF.

Nuclear counter stain : Hoechst 33342 (blue).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SMNDC1 antibody (AB227952)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SMNDC1 antibody (AB227952)

Paraffin-embedded SNU1 xenograft tissue stained for SMNDC1 using ab227952 at 1/500 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SMNDC1 antibody (AB227952)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SMNDC1 antibody (AB227952)

Paraffin-embedded C2C12 xenograft tissue stained for SMNDC1 using ab227952 at 1/500 dilution in immunohistochemical analysis.

Western blot - Anti-SMNDC1 antibody (AB227952)
  • WB

Supplier Data

Western blot - Anti-SMNDC1 antibody (AB227952)

12% SDS-PAGE gel.

All lanes:

Western blot - Anti-SMNDC1 antibody (ab227952) at 1/1000 dilution

All lanes:

IMR32 (human neuroblast cell line) whole cell lysate at 30 µg

Predicted band size: 27 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

ICC/IF, IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human SMNDC1. The exact immunogen used to generate this antibody is proprietary information.

O75940

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rhesus monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SMNDC1 also known as Small Nuclear Riboprotein SmN functions as an important player in pre-mRNA splicing. It is a protein weighing approximately 37 kDa. SMNDC1 shows expression in a variety of tissues notably in the brain and spinal cord. It interacts directly with components of the spliceosome suggesting that its primary mechanical role involves the assembly and rearrangement of spliceosomal complexes to facilitate accurate splicing processes.
Biological function summary

SMNDC1 assists in regulating gene expression through its contribution to mRNA maturation. SMNDC1 forms part of the spliceosomal complex which is important for the removal of introns from pre-mRNA transcripts. The assembly of this complex ensures that genetic messages are processed and translated correctly within the cell. Furthermore SMNDC1's involvement in RNA metabolism affects overall cellular function highlighting its importance in maintaining the integrity of cellular biology.

Pathways

SMNDC1 is integral in the spliceosome pathway where it collaborates with other proteins to perform splicing activities. This pathway influences gene expression patterns critical for cellular function and differentiation. Another related pathway is the RNA transport pathway where SMNDC1 is associated with proteins such as SMN1 and Gemin2. These associations highlight its contribution to the regulation of gene expression beyond splicing alone accommodating the broader requirements of cell survival and adaptability.

SMNDC1's involvement connects to neurodegenerative conditions such as spinal muscular atrophy (SMA). Dysfunction in its interactions particularly with the SMN1 protein disrupts normal spliceosomal activity which can lead to neuronal degeneration and muscle wasting characteristic of SMA. Additionally researchers have noted links between SMNDC1 and certain cancers which may arise from its role in genomic stability and cell cycle regulation. Understanding these disease associations provides insight into potential therapeutic targets for modulating SMNDC1's function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in spliceosome assembly.
See full target information SMNDC1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in cell and developmental biology 12:1487685 PubMed39723238

2024

Anticarcinogenic effects of ursodeoxycholic acid in pancreatic adenocarcinoma cell models.

Applications

Unspecified application

Species

Unspecified reactive species

Patrik Kovács,Szandra Schwarcz,Petra Nyerges,Tímea Ingrid Bíró,Gyula Ujlaki,Péter Bai,Edit Mikó
View all publications
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Product promise

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