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AB198715

Anti-SMOC2 antibody - C-terminal

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(2 Publications)

Rabbit Polyclonal SMOC2 antibody. C-terminal. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SMOC2.

View Alternative Names

SMAP2, MSTP117, SMOC2, SPARC-related modular calcium-binding protein 2, Secreted modular calcium-binding protein 2, Smooth muscle-associated protein 2, SMOC-2, SMAP-2

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SMOC2 antibody - C-terminal (AB198715)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SMOC2 antibody - C-terminal (AB198715)

Immunohistochemical analysis of paraffin-embedded human liver cancer tissue labeling SMOC2 with ab198715 at 1/35 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human SMOC2. The exact immunogen used to generate this antibody is proprietary information.

Q9H3U7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/25 - 1/100", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SMOC2 also known as SPARC-related modular calcium-binding protein 2 functions mechanically as an extracellular matrix-associated protein. It weighs approximately 48 kDa. SMOC2 shows expression mainly in tissues like bone skin and blood vessels where it contributes to cellular processes through its interaction with other matrix components. This protein contains multiple functional domains that allow it to bind calcium ions and interact with various molecules within the extracellular matrix.
Biological function summary

SMOC2 influences several processes related to tissue development and remodeling. It is involved in angiogenesis and cell proliferation impacting cellular communication through the matrix. SMOC2 does not usually form part of any large structural complexes but interacts with extracellular matrix proteins such as collagen and fibronectin to modulate their effects on cell behavior. It can regulate interactions between cells and their surrounding environment thereby contributing to maintaining tissue homeostasis.

Pathways

SMOC2 participates in the TGF-beta signaling pathway and the integrin-mediated signaling pathway. In the TGF-beta signaling pathway SMOC2 affects the regulation of growth and differentiation in various cell types. It interacts with proteins such as TGF-beta and related receptors influencing their activity and downstream effects. While involved in integrin pathways SMOC2 further affects cell adhesion and migration by engaging with integrin receptors thereby playing a role in modulating cellular responses to environmental changes.

SMOC2 has associations with cancer progression and fibrosis. Abnormal SMOC2 expression can promote tumor growth as seen in some types of cancer due to its role in cell proliferation and angiogenesis. In the context of fibrosis SMOC2 might exacerbate tissue scarring processes by influencing extracellular matrix remodeling. SMOC2 also shows a connection with proteins like TGF-beta in these diseases highlighting its involvement in modifying pathological states through these signaling pathways.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Promotes matrix assembly and cell adhesiveness (By similarity). Can stimulate endothelial cell proliferation, migration, as well as angiogenesis.
See full target information SMOC2
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

BMC women's health 25:155 PubMed40181364

2025

Role of SMOC2 in adenomyosis: implications for ECM remodeling and EMT pathogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Lei-Na Wang,Li Ren,Lin Li,Shu-Lian Liu,Hua-Jie Lu,Meng-Lan Guo,Xiao-Min Niu,Shiwali Vinita,Shuang Ning,Li-Ping Han

International journal of molecular sciences 23: PubMed36142211

2022

The Relative Abundances of Human Leukocyte Antigen-E, α-Galactosidase A and α-Gal Antigenic Determinants Are Biased by Trichostatin A-Dependent Epigenetic Transformation of Triple-Transgenic Pig-Derived Dermal Fibroblast Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Marcin Samiec,Jerzy Wiater,Kamil Wartalski,Maria Skrzyszowska,Monika Trzcińska,Daniel Lipiński,Jacek Jura,Zdzisław Smorąg,Ryszard Słomski,Małgorzata Duda
View all publications
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