Anti-smooth muscle Myosin heavy chain I antibody [MYH11/923]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Smooth muscle myosin heavy chain 1 also known as MYH11 plays a significant role in the contractile function of smooth muscle tissues. It is a part of the myosin II family which are motor proteins responsible for converting chemical energy into mechanical force enabling muscle contraction. MYH11 has a high molecular mass approximately 220 kDa and exists primarily in smooth muscles like those in the walls of blood vessels and the gastrointestinal tract.

Biological function summary

MYH11 functions as a critical part of the contractile apparatus in smooth muscle cells. It interacts with actin filaments to initiate contraction utilizing ATP in the process. MYH11 often forms a complex with other proteins including light chains and myosin-binding proteins to ensure proper muscle contraction and relaxation. This complex stabilizes the filament structure optimizing muscle performance.

Pathways

MYH11 integrates into smooth muscle contraction pathways and the cytoskeletal signaling networks. Its activity involves interaction with the RhoA/Rho kinase pathway essential for muscle contraction regulation. Proteins such as actin and tropomyosin work closely with MYH11 in these pathways facilitating coordinated contraction and enabling cells to adapt to mechanical stress.

Associated diseases and disorders

MYH11 mutations or dysregulation associate with conditions like familial aortic aneurysm and patent ductus arteriosus. In these disorders the normal contractile function of smooth muscle can be compromised leading to vessel weakening. Additionally MYH11 may involve with proteins like actin and caldesmon in these pathologies where altered contractile proteins contribute to disease progression and symptoms.