Mouse Monoclonal smooth muscle Myosin heavy chain 11 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Tissue preparation containing MYH11 protein.
IgG1
Mouse
pH: 7.2 - 7.4
Preservative: 0.05% Sodium azide
Constituents: PBS, 0.05% BSA
Liquid
Monoclonal
IHC-P | |
---|---|
Human | Tested |
Rat | Predicted |
Cat | Predicted |
Chicken | Predicted |
Cow | Predicted |
Dog | Predicted |
Guinea pig | Predicted |
Pig | Predicted |
Rabbit | Predicted |
Species | Dilution info | Notes |
---|---|---|
Species Human | Dilution info 0.5-1 µg/mL | Notes Incubate with primary antibody for 30 minutes at room temperature. Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species | Dilution info | Notes |
---|---|---|
Species Rat, Rabbit, Chicken, Guinea pig, Cow, Cat, Dog, Pig | Dilution info - | Notes - |
Select an associated product type
Myosin-11, Myosin heavy chain 11, SMMHC, KIAA0866, MYH11
Mouse Monoclonal smooth muscle Myosin heavy chain 11 antibody. Suitable for IHC-P and reacts with Human samples. Immunogen corresponding to Tissue preparation containing MYH11 protein.
Myosin-11, Myosin heavy chain 11, SMMHC, KIAA0866, MYH11
IgG1
Mouse
pH: 7.2 - 7.4
Preservative: 0.05% Sodium azide
Constituents: PBS, 0.05% BSA
Liquid
Monoclonal
SMMS-1
Affinity purification Protein A/G
kappa
Purified from bioreactor concentrate by Protein A/G.
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
Smooth muscle myosin heavy chain 1 also known as MYH11 plays a significant role in the contractile function of smooth muscle tissues. It is a part of the myosin II family which are motor proteins responsible for converting chemical energy into mechanical force enabling muscle contraction. MYH11 has a high molecular mass approximately 220 kDa and exists primarily in smooth muscles like those in the walls of blood vessels and the gastrointestinal tract.
MYH11 functions as a critical part of the contractile apparatus in smooth muscle cells. It interacts with actin filaments to initiate contraction utilizing ATP in the process. MYH11 often forms a complex with other proteins including light chains and myosin-binding proteins to ensure proper muscle contraction and relaxation. This complex stabilizes the filament structure optimizing muscle performance.
MYH11 integrates into smooth muscle contraction pathways and the cytoskeletal signaling networks. Its activity involves interaction with the RhoA/Rho kinase pathway essential for muscle contraction regulation. Proteins such as actin and tropomyosin work closely with MYH11 in these pathways facilitating coordinated contraction and enabling cells to adapt to mechanical stress.
MYH11 mutations or dysregulation associate with conditions like familial aortic aneurysm and patent ductus arteriosus. In these disorders the normal contractile function of smooth muscle can be compromised leading to vessel weakening. Additionally MYH11 may involve with proteins like actin and caldesmon in these pathologies where altered contractile proteins contribute to disease progression and symptoms.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
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Full details and terms and conditions can be found here:
Terms & Conditions.
Formalin-fixed, paraffin-embedded human breast carcinoma tissue stained for smooth muscle Myosin heavy chain I using ab233939 at 1 μg/ml in immunohistochemical analysis.
Formalin-fixed, paraffin-embedded human leiomyosarcoma tissue stained for smooth muscle Myosin heavy chain I using ab233939 at 1 μg/ml in immunohistochemical analysis.
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