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AB213631

Anti-SMOX antibody

1

(1 Review)

|

(3 Publications)

Rabbit Polyclonal SMOX antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human SMOX aa 150-200.

View Alternative Names

C20orf16, SMO, UNQ3039/PRO9854, SMOX, Spermine oxidase, Polyamine oxidase 1, PAO-1, PAOh1

1 Images
Western blot - Anti-SMOX antibody (AB213631)
  • WB

Supplier Data

Western blot - Anti-SMOX antibody (AB213631)

All lanes:

Western blot - Anti-SMOX antibody (ab213631) at 1/500 dilution

Lane 1:

HEK-293T cells overexpressing Human SMOX

Lane 2:

HEK-293T cells overexpressing Human SMOX with SMOX immunizing peptide (Human,151-165)

Secondary

All lanes:

Goat Anti-Rabbit IgG-Peroxidase

Predicted band size: 62 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human SMOX aa 150-200. The exact immunogen used to generate this antibody is proprietary information.

Q9NWM0

Specificity

ab213631 is also expected to react with isoforms 2, 4 and 6 of Human SMOX

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Alternative Products

Primary Antibodies

AB150971

Anti-SMOX antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SMOX antibody (AB150971)

  • 0
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Complementary Products

Primary Antibodies

AB156879

Anti-Spermine synthase antibody [EPR9252(B)]

RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-Spermine synthase antibody [EPR9252(B)] (AB156879)

  • 0
  • 0
Primary Antibodies

AB97395

Anti-Ornithine Decarboxylase/ODC antibody

Western blot - Anti-Ornithine Decarboxylase/ODC antibody (AB97395)

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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  • 20
Primary Antibodies

AB9485

Anti-GAPDH antibody - Loading Control

BOND RX™ Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-GAPDH antibody - Loading Control (AB9485)

  • 5
  • 88
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purity
IgG fraction
Storage buffer
pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SMOX also known as spermine oxidase is an enzyme that catalyzes the oxidation of spermine to spermidine releasing hydrogen peroxide and 3-aminopropanal. This enzyme is important in the polyamine metabolism process. SMOX has a molecular mass of approximately 66 kDa. It is expressed in various tissues including the liver kidney and other tissues with high metabolic activity.
Biological function summary

SMOX is essential for polyamine catabolism influencing cell growth and proliferation. It does not function as part of a complex but works independently to regulate intracellular levels of polyamines. The balance of polyamines like spermine and spermidine is critical for cellular functions impacting cell cycle regulation and apoptosis.

Pathways

The enzymatic activity of SMOX plays an important role in the polyamine metabolic pathway. This pathway interconnects with the urea cycle and is involved in the regulation of cellular proliferation. SMOX influences the activity of proteins like ornithine decarboxylase (ODC) which is vital in polyamine synthesis. By controlling polyamine levels SMOX indirectly modulates signaling pathways associated with cellular responses and stress reactions.

SMOX has a connection with cancer and neurodegenerative diseases. Abnormal expression of SMOX can disrupt polyamine homeostasis leading to oxidative stress and promoting tumorigenesis. In cancer SMOX activity often pairs with increased levels of ODC contributing to tumor progression. In neurodegenerative diseases such as Alzheimer's disease SMOX activity is linked to elevated oxidative stress resulting in neuronal damage and cognitive decline. The regulation of SMOX and polyamine metabolism remains a focus of research for therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.
See full target information SMOX
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 15:1613458 PubMed40823069

2025

Polyamine metabolism related gene index prediction of prognosis and immunotherapy response in breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ruoya Wang,Shouliang Cai,Qing Gao,Yidong Chen,Xue Han,Fangjian Shang,Chunyan Liang,Guolian Zhu,Bo Chen

Hepatology research : the official journal of the 48:967-977 PubMed29923661

2018

Spermine oxidase is upregulated and promotes tumor growth in hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Tingting Hu,Dalong Sun,Jie Zhang,Ruyi Xue,Harry L A Janssen,Wenqing Tang,Ling Dong

Journal of the American Society of Nephrology : JA 29:2310-2325 PubMed30042193

2018

Interactions between Macrophages and Cyst-Lining Epithelial Cells Promote Kidney Cyst Growth in -Deficient Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Yang,Meihan Chen,Jie Zhou,Jiayi Lv,Shuwei Song,LiLi Fu,Jiejian Chen,Ming Yang,Changlin Mei
View all publications
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Product promise

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