Rabbit Polyclonal SNIP1 antibody. Suitable for IHC-P, WB and reacts with Mouse, Rat, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SNIP1 aa 1-350.
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Publications
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- Nature communications 13:21922022KMT5A-methylated SNIP1 promotes triple-negative breast cancer metastasis by activating YAP signaling.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBo Yu,Jun Su,Qiqi Shi,Qing Liu,Jun Ma,Guoqing Ru,Lei Zhang,Jian Zhang,Xichun Hu,Jianming TangPubMed 35449131
- American journal of human genetics 109:116-1352021Functional analysis of the 1p34.3 risk locus implicates GNL2 in high-grade serous ovarian cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesKoji Nakamura,Brett M Reid,Ann Chen,Zhihua Chen,Ellen L Goode,Jennifer B Permuth,Jamie K Teer,Jonathan Tyrer,Xiaoqing Yu,Peter A Kanetsky,Paul D Pharoah,Simon A Gayther,Thomas A Sellers,Kate Lawrenson,Florian A KarrethPubMed 34965383
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Recombinant Fragment Protein within Human SNIP1 aa 1-350. The exact immunogen used to generate this antibody is proprietary information. Database link Q8TAD8
Reactivity data
Select an application| IHC-P | WB | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Tested | Expected |
| Rat | Tested | Expected |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/100.00000 - 1/500.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species Rat | Dilution info 1/100.00000 - 1/500.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species Human | Dilution info 1/100.00000 - 1/500.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/1000.00000 - 1/10000.00000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info Use at an assay dependent concentration. | Notes - |
Associated Products
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Target data
Function
Required for pre-mRNA splicing as component of the spliceosome (PubMed:29360106). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.
Alternative names
Smad nuclear-interacting protein 1, FHA domain-containing protein SNIP1, SNIP1
Recommended products
Rabbit Polyclonal SNIP1 antibody. Suitable for IHC-P, WB and reacts with Mouse, Rat, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SNIP1 aa 1-350.
Alternative names
Smad nuclear-interacting protein 1, FHA domain-containing protein SNIP1, SNIP1
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 20% Glycerol (glycerin, glycerine), 1% BSA- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human SNIP1 aa 1-350. The exact immunogen used to generate this antibody is proprietary information. Database link Q8TAD8
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
SNIP1 also known as Smad nuclear interacting protein 1 is a nuclear protein with a mass of approximately 43 kDa. This protein mechanically functions as a nuclear co-repressor that interacts with Smad proteins and the transcription factor c-Myc. SNIP1 is expressed in various tissues notably in embryonic and adult brain tissues which indicates a role in development and cellular regulation within these areas.
- Biological function summary
SNIP1 influences transcriptional repression by modulating the transcriptional activity of the Smad4 complex. SNIP1 interacts with several regulatory proteins to modulate gene expression. By inhibiting the transcriptional activity of Smad proteins SNIP1 can regulate various genes involved in cell growth and proliferation affecting how cells behave in different contexts.
- Pathways
SNIP1 participates in important cellular signaling pathways such as the TGF-beta and BMP signaling pathways. SNIP1 interacts with proteins in these pathways including Smad2 and Smad3 to control cellular responses to growth factors. By influencing these pathways SNIP1 plays a part in cellular processes like apoptosis and differentiation.
- Associated diseases and disorders
SNIP1 has implications in cancer and neurodevelopmental disorders. In cancer SNIP1's interaction with proteins like c-Myc and Smad3 plays a role in tumor progression highlighting its involvement in oncogenic pathways. In neurodevelopmental disorders altered SNIP1 expression affects normal brain development suggesting links between its expression and conditions such as autism spectrum disorders.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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4 product images
Western blot - Anti-SNIP1 antibody (ab126194)
10% SDS PAGE
All lanes: Western blot - Anti-SNIP1 antibody (ab126194) at 1/5000 dilution
All lanes: Jurkat whole cell lysate at 30 µg
Predicted band size: 40 kDa, 46 kDa, 47 kDa, 48 kDa, 49 kDa, 54 kDa, 59 kDa, 68 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SNIP1 antibody (ab126194)
ab126194, at 1/500 dilution, staining SNIP1 in Paraffin-embedded Human 59T xenograft tissue by Immunohistochemistry.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SNIP1 antibody (ab126194)
ab126194, at 1/500 dilution, staining SNIP1 in Paraffin-embedded HumRat RT2 xenograft tissue by Immunohistochemistry.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SNIP1 antibody (ab126194)
ab126194, at 1/500 dilution, staining SNIP1 in Paraffin-embedded Mouse Muscle tissue by Immunohistochemistry.
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