Rabbit Polyclonal SNM1A antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human DCLRE1A aa 400-500.
View Alternative Names
KIAA0086, SNM1, SNM1A, DCLRE1A, DNA cross-link repair 1A protein, Beta-lactamase DCLRE1A, SNM1 homolog A, hSNM1, hSNM1A
- IP
Supplier Data
Immunoprecipitation - Anti-SNM1A antibody (AB226003)
SNM1A was immunoprecipitated from HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate (1 mg for IP, 20% of IP loaded) with ab226003 at 6 μg/mg lysate. Western blot was performed from the immunoprecipitate using ab226003 at 1 μg/ml.
Lane 1 : ab226003 IP in HEK-293T whole cell lysate.
Lane 2 : Control IgG IP in HEK-293T whole cell lysate.
Detection : Chemiluminescence with exposure time of 30 seconds.
All lanes:
Immunoprecipitation - Anti-SNM1A antibody (ab226003)
Predicted band size: 116 kDa
false
- WB
Supplier Data
Western blot - Anti-SNM1A antibody (AB226003)
All lanes:
Western blot - Anti-SNM1A antibody (ab226003) at 0.1 µg/mL
Lane 1:
HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate at 50 µg
Lane 2:
HEK-293T whole cell lysate at 15 µg
Lane 3:
HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 50 µg
Lane 4:
Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate at 50 µg
Predicted band size: 116 kDa
true
Exposure time: 3min
Reactivity data
Properties and storage information
Form
Purification technique
Purification notes
Storage buffer
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
SNM1A participates in DNA damage response and repair. It functions as part of the DNA interstrand cross-link repair and processes stalled replication forks. SNM1A does not form part of a larger protein complex but works alongside other proteins like FANCD2 and FANCI. Its activity is essential for preventing DNA damage accumulation which may lead to cell death or cancerous growths.
Pathways
SNM1A operates in the Fanconi anemia pathway facilitating the repair of interstrand cross-links which are critical obstacles to DNA replication. It associates with components like the SLX4 complex and the FANCD2-FANCI complex helping resolve replication issues. Another important pathway includes the homologous recombination repair interconnecting SNM1A with RAD51 a protein important in the exchange of genetic material for accurate DNA repair.
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Target data
Publications (1)
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Thoracic cancer 14:2093-2104 PubMed37349884
2023
Applications
Unspecified application
Species
Unspecified reactive species
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