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AB189653

Anti-SnoN/SNO antibody - N-terminal

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(1 Publication)

Rabbit Polyclonal SnoN/SNO antibody. N-terminal. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human SKIL.

View Alternative Names

SNO, SKIL, Ski-like protein, Ski-related oncogene, Ski-related protein

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SnoN/SNO antibody - N-terminal (AB189653)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SnoN/SNO antibody - N-terminal (AB189653)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human lung, respiratory epithelium tissue labeling SnoN/SNO with ab189653 at 5 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SnoN/SNO antibody - N-terminal (AB189653)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SnoN/SNO antibody - N-terminal (AB189653)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human placenta tissue labeling SnoN/SNO with ab189653 at 5 μg/ml.

Immunocytochemistry/ Immunofluorescence - Anti-SnoN/SNO antibody - N-terminal (AB189653)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SnoN/SNO antibody - N-terminal (AB189653)

Immunofluorescent analysis of mouse lung cells labeling SnoN/SNO with ab189653 at 20 μg/ml.

Western blot - Anti-SnoN/SNO antibody - N-terminal (AB189653)
  • WB

Supplier Data

Western blot - Anti-SnoN/SNO antibody - N-terminal (AB189653)

Lane 1:

Western blot - Anti-SnoN/SNO antibody - N-terminal (ab189653) at 0.5 µg/mL

Lane 2:

Western blot - Anti-SnoN/SNO antibody - N-terminal (ab189653) at 1 µg/mL

All lanes:

A431 cell lysate

Predicted band size: 77 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, ICC/IF, IHC-P

applications

Immunogen

Synthetic Peptide within Human SKIL. The exact immunogen used to generate this antibody is proprietary information.

P12757

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SnoN also known as SNO is a transcriptional co-repressor that plays a significant role in cellular signaling. It has a molecular mass of approximately 75 kDa and is expressed in various tissues including the brain liver and muscle. The protein serves as an important regulator by interacting with different transcription factors influencing gene expression. SnoN is often involved in negative regulation of the transforming growth factor-beta (TGF-β) signaling pathway acting through binding and repressing activities of Smad proteins.
Biological function summary

SnoN influences cell growth and differentiation. It exists as part of a complex with other co-repressors and transcription factors particularly within the TGF-β signaling pathway. SnoN modulates the balance between cell proliferation and apoptosis therefore playing an important role in tissue homeostasis. Its regulation is essential for proper development and maintaining normal cellular function.

Pathways

SnoN has a central role in the TGF-β signaling pathway. This pathway is important for controlling a broad range of cellular processes including proliferation differentiation and apoptosis. Within this pathway SnoN interacts with Smad proteins to regulate gene transcription negatively. Additionally SnoN has connections with the ERK/MAPK pathway which links it to other important cellular processes and growth factor signals that influence cell fate decisions.

SnoN has been associated with cancer development particularly in breast cancer and pancreatic cancer. Its deregulation may lead to uncontrolled cell growth and resistance to apoptosis driven by altered TGF-β signaling. SnoN is connected to other proteins such as Smad2 and Smad4 which are known to play roles in the progression of these cancers. Understanding SnoN's role and interactions might provide new insights into therapeutic targets for treating these diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May have regulatory role in cell division or differentiation in response to extracellular signals.
See full target information SKIL
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 11:722814 PubMed34692499

2021

Exploring Somatic Alteration Associating With Aggressive Behaviors of Papillary Thyroid Carcinomas by Targeted Sequencing.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Li,Wei Gao,Xiaojun Cai,Anqi Jin,Jian Shen,Yichun Zhang,Yutong Chen,Bing Hu,Tao Zeng,Xiangtian Yu,Yuanyi Zheng,Yan Wang
View all publications
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Product promise

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For full details, please see our Terms & Conditions

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