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AB69992

Anti-SNPH antibody

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(2 Publications)

Rabbit Polyclonal SNPH antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SNPH aa 50-150.

View Alternative Names

KIAA0374, SNPH, Syntaphilin

3 Images
Immunocytochemistry/ Immunofluorescence - Anti-SNPH antibody (AB69992)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-SNPH antibody (AB69992)

Immunofluorescence of Syntaphilin in Human Brain cells using ab69992 at 20 ug/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SNPH antibody (AB69992)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SNPH antibody (AB69992)

ab69992 at 5 μg/ml staining SNPH in human brain tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded tissue sections).

Western blot - Anti-SNPH antibody (AB69992)
  • WB

Unknown

Western blot - Anti-SNPH antibody (AB69992)

Lane 1:

Western blot - Anti-SNPH antibody (ab69992) at 2 µg/mL

Lane 2:

Western blot - Anti-SNPH antibody (ab69992) at 4 µg/mL

All lanes:

Human brain tissue lysate at 15 µg

Predicted band size: 54 kDa

Observed band size: 115 kDa,120 kDa,57 kDa,65 kDa,70 kDa,75 kDa,84 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Synthetic Peptide within Human SNPH aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

O15079

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "2-4 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SNPH also known as Syntaphilin is a protein that acts mechanically by binding to microtubules which is important for its role in anchoring mitochondria within axons. It has a molecular mass of approximately 66 kDa. SNPH predominantly expresses in neurons particularly in the brain suggesting its significant role in the nervous system. This anchoring function helps to regulate energy distribution and calcium buffering within axons highlighting its importance in maintaining proper neuronal function.
Biological function summary

This protein modulates mitochondrial distribution by stabilizing microtubules and interacting with the mitochondrial outer membrane. SNPH operates as a part of a complex with motor proteins and microtubular structures which facilitates the stationary positioning of mitochondria along the axons. It helps in energy homeostasis and signal transmission supporting synaptic activity and neuronal health. By influencing mitochondrial dynamics SNPH ensures that neurons maintain energy efficiency and health.

Pathways

SNPH plays a role in cellular processes like the mitochondrial transport and microtubular dynamics pathway. This involves SNPH interacting with proteins such as kinesin and dynein which are motor proteins that move cellular cargo along microtubules. SNPH helps anchor mitochondria by counteracting these transport proteins which helps in the proper positioning of mitochondria needed for neuron function. SNPH's activity is connected to the intracellular energy distribution pathway influencing the energy supply necessary for high-demand areas within the neurons.

SNPH is associated with neurodegenerative conditions such as Alzheimer’s disease and Parkinson’s disease. These diseases feature mitochondrial dysfunction and energy imbalances where SNPH’s role in mitochondrial anchoring and distribution becomes disrupted contributing to disease advancement. SNPH’s interactions with amyloid precursor protein in Alzheimer's and alpha-synuclein in Parkinson’s have shown relevance in the pathological processes of these disorders. Understanding SNPH’s function offers insights into therapeutic approaches targeting mitochondrial dynamics in neurodegenerative diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Inhibits SNARE complex formation by absorbing free STX1A.
See full target information SNPH
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in pharmacology 13:1049818 PubMed36588703

2022

Naringin attenuates fructose-induced NAFLD progression in rats through reducing endogenous triglyceride synthesis and activating the Nrf2/HO-1 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Sirinat Pengnet,Phinsuda Sumarithum,Nuttaphong Phongnu,Sakdina Prommaouan,Napapas Kantip,Ittipon Phoungpetchara,Wachirawadee Malakul

Frontiers in aging neuroscience 13:632374 PubMed33762923

2021

Dl-3-n-Butylphthalide Alleviates Demyelination and Improves Cognitive Function by Promoting Mitochondrial Dynamics in White Matter Lesions.

Applications

Unspecified application

Species

Unspecified reactive species

Yiwei Feng,Min Guo,Hongchen Zhao,Sida Han,Yining Hao,Yiwen Yuan,Weiwei Shen,Jian Sun,Qiang Dong,Mei Cui
View all publications
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