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AB192605

Anti-SNPH antibody [EPR14115(2)]

4

(1 Review)

|

(4 Publications)

Rabbit Recombinant Monoclonal SNPH antibody. Suitable for WB, IHC-P and reacts with Rat, Human, Mouse samples. Cited in 4 publications.

View Alternative Names

KIAA0374, SNPH, Syntaphilin

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SNPH antibody [EPR14115(2)] (AB192605)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SNPH antibody [EPR14115(2)] (AB192605)

Immunohistochemical analysis of formalin fixed paraffin embedded human brain labeling SNPH with ab192605 at 1/1000 (1μg/ml) dilution and HRP Polymer to Rabbit/mouse IgG as secondary. Counterstained with Hematoxylin.

Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SNPH antibody [EPR14115(2)] (AB192605)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SNPH antibody [EPR14115(2)] (AB192605)

Immunohistochemical analysis of formalin fixed paraffin embedded mouse brain labeling SNPH with ab192605 at 1/1000 (1μg/ml) dilution and HRP Polymer to Rabbit/mouse IgG as secondary. Counterstained with Hematoxylin.

Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Western blot - Anti-SNPH antibody [EPR14115(2)] (AB192605)
  • WB

Supplier Data

Western blot - Anti-SNPH antibody [EPR14115(2)] (AB192605)

All lanes:

Western blot - Anti-SNPH antibody [EPR14115(2)] (ab192605) at 1/10000 dilution

All lanes:

Human hippocamus tissue lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 54 kDa

false

Western blot - Anti-SNPH antibody [EPR14115(2)] (AB192605)
  • WB

Supplier Data

Western blot - Anti-SNPH antibody [EPR14115(2)] (AB192605)

All lanes:

Western blot - Anti-SNPH antibody [EPR14115(2)] (ab192605) at 1/1000 dilution

All lanes:

Human fetal brain tissue lysate at 20 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 54 kDa

false

Western blot - Anti-SNPH antibody [EPR14115(2)] (AB192605)
  • WB

Supplier Data

Western blot - Anti-SNPH antibody [EPR14115(2)] (AB192605)

All lanes:

Western blot - Anti-SNPH antibody [EPR14115(2)] (ab192605) at 1/5000 dilution

All lanes:

Rat brain at 10 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Predicted band size: 54 kDa

false

  • Carrier free

    Anti-SNPH antibody [EPR14115(2)] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR14115(2)

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

IHC-P, WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

SNPH also known as Syntaphilin is a protein that acts mechanically by binding to microtubules which is important for its role in anchoring mitochondria within axons. It has a molecular mass of approximately 66 kDa. SNPH predominantly expresses in neurons particularly in the brain suggesting its significant role in the nervous system. This anchoring function helps to regulate energy distribution and calcium buffering within axons highlighting its importance in maintaining proper neuronal function.
Biological function summary

This protein modulates mitochondrial distribution by stabilizing microtubules and interacting with the mitochondrial outer membrane. SNPH operates as a part of a complex with motor proteins and microtubular structures which facilitates the stationary positioning of mitochondria along the axons. It helps in energy homeostasis and signal transmission supporting synaptic activity and neuronal health. By influencing mitochondrial dynamics SNPH ensures that neurons maintain energy efficiency and health.

Pathways

SNPH plays a role in cellular processes like the mitochondrial transport and microtubular dynamics pathway. This involves SNPH interacting with proteins such as kinesin and dynein which are motor proteins that move cellular cargo along microtubules. SNPH helps anchor mitochondria by counteracting these transport proteins which helps in the proper positioning of mitochondria needed for neuron function. SNPH's activity is connected to the intracellular energy distribution pathway influencing the energy supply necessary for high-demand areas within the neurons.

SNPH is associated with neurodegenerative conditions such as Alzheimer’s disease and Parkinson’s disease. These diseases feature mitochondrial dysfunction and energy imbalances where SNPH’s role in mitochondrial anchoring and distribution becomes disrupted contributing to disease advancement. SNPH’s interactions with amyloid precursor protein in Alzheimer's and alpha-synuclein in Parkinson’s have shown relevance in the pathological processes of these disorders. Understanding SNPH’s function offers insights into therapeutic approaches targeting mitochondrial dynamics in neurodegenerative diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Inhibits SNARE complex formation by absorbing free STX1A.
See full target information SNPH
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Journal of extracellular biology 4:e70084 PubMed40901048

2025

MicroRNA (miRNA) in Plasma Small Extracellular Vesicles (sEV) as Potential Early Indicators of Dairy Cow Subfertility.

Applications

Unspecified application

Species

Unspecified reactive species

Pevindu Abeysinghe,Natalie Turner,Holly Flay,Susanne Meier,Leila Cuttle,Murray D Mitchell

The Journal of neuroscience : the official journal of the Society for Neuroscience 42:7318-7329 PubMed35970564

2022

Tripartite Crosstalk between Cytokine IL-1β, NMDA-R and Misplaced Mitochondrial Anchor in Neuronal Dendrites Is a Novel Pathway for Neurodegeneration in Inflammatory Diseases.

Applications

Unspecified application

Species

Unspecified reactive species

Dinesh C Joshi,Chuan-Li Zhang,Deepali Mathur,Alex Li,Gaurav Kaushik,Zu-Hang Sheng,Shing-Yan Chiu

Current biology : CB 31:3098-3114.e7 PubMed34087103

2021

Reprogramming an energetic AKT-PAK5 axis boosts axon energy supply and facilitates neuron survival and regeneration after injury and ischemia.

Applications

Unspecified application

Species

Unspecified reactive species

Ning Huang,Sunan Li,Yuxiang Xie,Qi Han,Xiao-Ming Xu,Zu-Hang Sheng

Cell reports 29:685-696.e5 PubMed31618636

2019

Inappropriate Intrusion of an Axonal Mitochondrial Anchor into Dendrites Causes Neurodegeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Dinesh C Joshi,Chuan-Li Zhang,Lavanya Babujee,Jason D Vevea,Benjamin K August,Zu-Hang Sheng,Edwin R Chapman,Timothy M Gomez,Shing Yan Chiu
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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