Anti-SNPH antibody [EPR14115(2)]

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

SNPH also known as Syntaphilin is a protein that acts mechanically by binding to microtubules which is important for its role in anchoring mitochondria within axons. It has a molecular mass of approximately 66 kDa. SNPH predominantly expresses in neurons particularly in the brain suggesting its significant role in the nervous system. This anchoring function helps to regulate energy distribution and calcium buffering within axons highlighting its importance in maintaining proper neuronal function.

Biological function summary

This protein modulates mitochondrial distribution by stabilizing microtubules and interacting with the mitochondrial outer membrane. SNPH operates as a part of a complex with motor proteins and microtubular structures which facilitates the stationary positioning of mitochondria along the axons. It helps in energy homeostasis and signal transmission supporting synaptic activity and neuronal health. By influencing mitochondrial dynamics SNPH ensures that neurons maintain energy efficiency and health.

Pathways

SNPH plays a role in cellular processes like the mitochondrial transport and microtubular dynamics pathway. This involves SNPH interacting with proteins such as kinesin and dynein which are motor proteins that move cellular cargo along microtubules. SNPH helps anchor mitochondria by counteracting these transport proteins which helps in the proper positioning of mitochondria needed for neuron function. SNPH's activity is connected to the intracellular energy distribution pathway influencing the energy supply necessary for high-demand areas within the neurons.

Associated diseases and disorders

SNPH is associated with neurodegenerative conditions such as Alzheimer’s disease and Parkinson’s disease. These diseases feature mitochondrial dysfunction and energy imbalances where SNPH’s role in mitochondrial anchoring and distribution becomes disrupted contributing to disease advancement. SNPH’s interactions with amyloid precursor protein in Alzheimer's and alpha-synuclein in Parkinson’s have shown relevance in the pathological processes of these disorders. Understanding SNPH’s function offers insights into therapeutic approaches targeting mitochondrial dynamics in neurodegenerative diseases.