AB39327

Anti-SOAT 1/ACAT1 antibody

Name: Anti-SOAT 1/ACAT1 antibody (ab39327) | Abcam
Brand: Abcam Limited
SKU: AB39327
Price: 525 USD
Availability: InStock

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(17 Publications)

Rabbit Polyclonal SOAT 1/ACAT1 antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 17 publications.

View Alternative Names

ACACT, ACACT1, ACAT, ACAT1, SOAT, STAT, SOAT1, Sterol O-acyltransferase 1, Acyl-coenzyme A:cholesterol acyltransferase 1, Cholesterol acyltransferase 1, ACAT-1

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOAT 1/ACAT1 antibody (AB39327)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOAT 1/ACAT1 antibody (AB39327)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) of human adreanal tissue using ab39327 at 1/200 after heat induced antigen reteval in pH 6.0 citrate buffer. DAB staining.

Unknown

Western blot - Anti-SOAT 1/ACAT1 antibody (AB39327)

The 65 kDa band detected is the native form of ACAT1.

All lanes:

Western blot - Anti-SOAT 1/ACAT1 antibody (ab39327)

Lane 1:

Rat Liver (30µg)

Lane 2:

HepG2 cell lysate (30µg)

Predicted band size: 65 kDa

Observed band size: 50 kDa,65 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat, Human

Applications

WB, IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed : 16154994, PubMed : 16647063, PubMed : 32433613, PubMed : 32433614, PubMed : 32944968, PubMed : 9020103). Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed : 16154994, PubMed : 9020103). Preferentially utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) as a substrate : shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions (PubMed : 11294643, PubMed : 32433614).

See full target information SOAT1

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Publications (17)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 25:231 PubMed37153054

2023

Evaluation of sterol‑o‑acyl transferase 1 and cholesterol ester levels in plasma, peritoneal fluid and tumor tissue of patients with endometrial cancer: A pilot study.

Applications

Unspecified application

Species

Unspecified reactive species

Vijayalakshmi N Ayyagari,Miao Li,Paula Diaz-Sylvester,Kathleen Groesch,Teresa Wilson,Zvi Pasman,Ejaz M Shah,Andrea Braundmeier-Fleming,Laurent Brard

BMC cancer 22:387 PubMed35399074

2022

Assessment of the diagnostic and prognostic relevance of ACAT1 and CE levels in plasma, peritoneal fluid and tumor tissue of epithelial ovarian cancer patients - a pilot study.

Applications

Unspecified application

Species

Unspecified reactive species

Vijayalakshmi Ayyagari,Maio Li,Zvi Pasman,Xinjia Wang,Somaja Louis,Paula Diaz-Sylvester,Kathleen Groesch,Teresa Wilson,Laurent Brard

Aging 14:2678-2694 PubMed35354120

2022

piRNA-6426 increases DNMT3B-mediated SOAT1 methylation and improves heart failure.

Applications

Unspecified application

Species

Unspecified reactive species

Nier Zhong,Xiting Nong,Jiayu Diao,Guang Yang

International journal of molecular sciences 23: PubMed35409086

2022

SOAT1: A Suitable Target for Therapy in High-Grade Astrocytic Glioma?

Applications

Unspecified application

Species

Unspecified reactive species

Mario Löhr,Wolfgang Härtig,Almut Schulze,Matthias Kroiß,Silviu Sbiera,Constantin Lapa,Bianca Mages,Sabrina Strobel,Jennifer Elisabeth Hundt,Simone Bohnert,Stefan Kircher,Sudha Janaki-Raman,Camelia-Maria Monoranu

Frontiers in pharmacology 12:769647 PubMed34790132

2021

SOAT1 Promotes Gastric Cancer Lymph Node Metastasis Through Lipid Synthesis.

Applications

Unspecified application

Species

Unspecified reactive species

Tingting Zhu,Zhangding Wang,Tianhui Zou,Lei Xu,Shu Zhang,Yali Chen,Chen Chen,Weijie Zhang,Shouyu Wang,Qingqing Ding,Guifang Xu

Prostate cancer and prostatic diseases 25:484-490 PubMed34326474

2021

High expression of Sterol-O-Acyl transferase 1 (SOAT1), an enzyme involved in cholesterol metabolism, is associated with earlier biochemical recurrence in high risk prostate cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Carolin Eckhardt,Iuliu Sbiera,Markus Krebs,Silviu Sbiera,Martin Spahn,Burkhard Kneitz,Steven Joniau,Martin Fassnacht,Hubert Kübler,Isabel Weigand,Matthias Kroiss

iScience 24:102722 PubMed34258555

2021

Stratification of patients with clear cell renal cell carcinoma to facilitate drug repositioning.

Applications

Unspecified application

Species

Unspecified reactive species

Xiangyu Li,Woonghee Kim,Kajetan Juszczak,Muhammad Arif,Yusuke Sato,Haruki Kume,Seishi Ogawa,Hasan Turkez,Jan Boren,Jens Nielsen,Mathias Uhlen,Cheng Zhang,Adil Mardinoglu

The Journal of clinical endocrinology and metabolism 105: PubMed32449514

2020

Expression of SOAT1 in Adrenocortical Carcinoma and Response to Mitotane Monotherapy: An ENSAT Multicenter Study.

Applications

Unspecified application

Species

Unspecified reactive species

Isabel Weigand,Barbara Altieri,Amanda M F Lacombe,Vittoria Basile,Stefan Kircher,Laura-Sophie Landwehr,Jochen Schreiner,Maria C N Zerbini,Cristina L Ronchi,Felix Megerle,Alfredo Berruti,Letizia Canu,Marco Volante,Isabel Paiva,Silvia Della Casa,Silviu Sbiera,Martin Fassnacht,Maria Candida B V Fragoso,Massimo Terzolo,Matthias Kroiss

Lipids 55:309-327 PubMed32314395

2020

High Glucose and Liver Fatty Acid Binding Protein Gene Ablation Differentially Impact Whole Body and Liver Phenotype in High-Fat Pair-Fed Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Gregory G Martin,Danilo Landrock,Avery L McIntosh,Sherrelle Milligan,Kerstin K Landrock,Ann B Kier,John Mackie,Friedhelm Schroeder

Cancers 12: PubMed31963898

2020

Sterol O-Acyl Transferase 1 as a Prognostic Marker of Adrenocortical Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Amanda Meneses Ferreira Lacombe,Iberê Cauduro Soares,Beatriz Marinho de Paula Mariani,Mirian Yumie Nishi,João Evangelista Bezerra-Neto,Helaine da Silva Charchar,Vania Balderrama Brondani,Fabio Tanno,Victor Srougi,José Luiz Chambo,Ricardo Miguel Costa de Freitas,Berenice Bilharinho Mendonca,Ana O Hoff,Madson Q Almeida,Isabel Weigand,Matthias Kroiss,Maria Claudia Nogueira Zerbini,Maria Candida Barisson Villares Fragoso

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SOAT 1/ACAT1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOAT 1/ACAT1 antibody (AB39327)

Western blot - Anti-SOAT 1/ACAT1 antibody (AB39327)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Complementary Products

Assay Kits

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (17)

Product promise