AB137384

Anti-SOCS1 antibody

Name: Anti-SOCS1 antibody (ab137384) | Abcam
Brand: Abcam Limited
SKU: AB137384

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(5 Publications)

Rabbit Polyclonal SOCS1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human, Mouse samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human SOCS1 aa 100-200.

View Alternative Names

SSI1, TIP3, SOCS1, Suppressor of cytokine signaling 1, SOCS-1, JAK-binding protein, STAT-induced STAT inhibitor 1, Tec-interacting protein 3, JAB, SSI-1, TIP-3

5 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOCS1 antibody (AB137384)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOCS1 antibody (AB137384)

Immunohistochemical analysis of paraffin-embedded A549 xenograft labelling SOCS1 with ab137384 at 1/100 dilution.

Immunocytochemistry/ Immunofluorescence - Anti-SOCS1 antibody (AB137384)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-SOCS1 antibody (AB137384)

Immunofluorescence analysis of HeLa cells fixed in 4% paraformaldehyde at RT for 15 min labelling SOCS1 protein at cytoplasm and nucleus using ab137384 at a 1/200 dilution (Green). Hoechst 33342 was used for nuclear staining (Blue). Scale bar = 10 µm

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOCS1 antibody (AB137384)

Immunohistochemical analysis of mouse colon tissue stained for SOCS1 protein at nucleus with ab137384 at a 1/500 dilution.

Antigen retrieval : EDTA based, pH 8.0 buffer, 15min.

Unknown

Western blot - Anti-SOCS1 antibody (AB137384)

12% SDS PAGE

All lanes:

Western blot - Anti-SOCS1 antibody (ab137384) at 1/1000 dilution

All lanes:

Hep G2 whole cell lysate at 30 µg

Predicted band size: 23 kDa

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Supplier Data

Western blot - Anti-SOCS1 antibody (AB137384)

Samples were separated by 12% SDS PAGE.

All lanes:

Western blot - Anti-SOCS1 antibody (ab137384) at 1/2000 dilution

All lanes:

Mouse brain lysate at 50 µg

Predicted band size: 24 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human, Mouse

Applications

ICC/IF, WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human SOCS1 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

O15524

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF) (PubMed : 32499645, PubMed : 33087723). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity (PubMed : 9341160). Regulates IFN-gamma (IFNG)-mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed : 11278610, PubMed : 11313480).

See full target information SOCS1

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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

JID innovations : skin science from molecules to population health 5:100401 PubMed40927131

2025

Immunoregulatory Microenvironment in the Elderly Skin.

Applications

Unspecified application

Species

Unspecified reactive species

Yuri Shimizu,Hanako Koguchi-Yoshioka,Toshiki Kubo,Yutaka Matsumura,Shoichi Matsuda,Atsushi Tanemura,Michiko Nomori,Naoya Otani,Mifue Taminato,Koichi Tomita,Tateki Kubo,Manabu Fujimoto,Rei Watanabe

Frontiers in oncology 13:1208403 PubMed37916165

2023

Transcriptional signature of early cisplatin drug-tolerant persister cells in lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Rodolfo Chavez-Dominguez,Dolores Aguilar-Cazares,Mario Perez-Medina,Santiago Avila-Rios,Maribel Soto-Nava,Alfonso Mendez-Tenorio,Lorenzo Islas-Vazquez,Jesus J Benito-Lopez,Miriam Galicia-Velasco,Jose S Lopez-Gonzalez

Current issues in molecular biology 45:5598-5612 PubMed37504269

2023

SOCS1 as a Biomarker Candidate for HPV Infection and Prognosis of Head and Neck Squamous Cell Carcinomas.

Applications

Unspecified application

Species

Unspecified reactive species

Manli Guo,Lijie Zhang,Huihui Wang,Qiaozhen Zhou,Xinrang Zhu,Xinyu Fu,Jinlong Yang,Shanhe Liu,Dingcheng Guo,Baoping Zhang

Cancers 13: PubMed34885061

2021

CARMA3 Promotes Colorectal Cancer Cell Motility and Cancer Stemness via YAP-Mediated NF-κB Activation.

Applications

Unspecified application

Species

Unspecified reactive species

Ting-Yu Chang,Cheng-Tien Wu,Meei-Ling Sheu,Rong-Sen Yang,Shing-Hwa Liu

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 35:e21388 PubMed33724556

2021

Microtubule-dependent mechanism of anti-inflammatory effect of SOCS1 in endothelial dysfunction and lung injury.

Applications

Unspecified application

Species

Unspecified reactive species

Pratap Karki,Boyoung Cha,Chen-Ou Zhang,Yue Li,Yunbo Ke,Kamoltip Promnares,Kozo Kaibuchi,Akihiko Yoshimura,Konstantin G Birukov,Anna A Birukova

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SOCS1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOCS1 antibody (AB137384)

Immunocytochemistry/ Immunofluorescence - Anti-SOCS1 antibody (AB137384)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOCS1 antibody (AB137384)

Western blot - Anti-SOCS1 antibody (AB137384)

Western blot - Anti-SOCS1 antibody (AB137384)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (5)

Product promise