Rabbit Polyclonal SOCS1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human SOCS1 aa 100-200.
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Publications
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- Frontiers in oncology 13:12084032023Transcriptional signature of early cisplatin drug-tolerant persister cells in lung adenocarcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRodolfo Chavez-Dominguez,Dolores Aguilar-Cazares,Mario Perez-Medina,Santiago Avila-Rios,Maribel Soto-Nava,Alfonso Mendez-Tenorio,Lorenzo Islas-Vazquez,Jesus J Benito-Lopez,Miriam Galicia-Velasco,Jose S Lopez-GonzalezPubMed 37916165
- Current issues in molecular biology 45:5598-56122023SOCS1 as a Biomarker Candidate for HPV Infection and Prognosis of Head and Neck Squamous Cell Carcinomas.Applications:Unspecified applicationReactive species:Unspecified reactive speciesManli Guo,Lijie Zhang,Huihui Wang,Qiaozhen Zhou,Xinrang Zhu,Xinyu Fu,Jinlong Yang,Shanhe Liu,Dingcheng Guo,Baoping ZhangPubMed 37504269
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology 35:e213882021Microtubule-dependent mechanism of anti-inflammatory effect of SOCS1 in endothelial dysfunction and lung injury.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPratap Karki,Boyoung Cha,Chen-Ou Zhang,Yue Li,Yunbo Ke,Kamoltip Promnares,Kozo Kaibuchi,Akihiko Yoshimura,Konstantin G Birukov,Anna A BirukovaPubMed 33724556
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Synthetic Peptide within Human SOCS1 aa 100-200. The exact immunogen used to generate this antibody is proprietary information. Database link O15524
Reactivity data
Select an application| IHC-P | WB | |
|---|---|---|
| Human | Tested | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/1000.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
Associated Products
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Target data
Function
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Through binding to JAKs and IFNGR1, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
Alternative names
Suppressor of cytokine signaling 1, SOCS-1, JAK-binding protein, STAT-induced STAT inhibitor 1, Tec-interacting protein 3, JAB, SSI-1, TIP-3, TIP3, SSI1, SOCS1
Recommended products
Rabbit Polyclonal SOCS1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human SOCS1 aa 100-200.
Alternative names
Suppressor of cytokine signaling 1, SOCS-1, JAK-binding protein, STAT-induced STAT inhibitor 1, Tec-interacting protein 3, JAB, SSI-1, TIP-3, TIP3, SSI1, SOCS1
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Synthetic Peptide within Human SOCS1 aa 100-200. The exact immunogen used to generate this antibody is proprietary information. Database link O15524
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-SOCS1 antibody (ab137384)
12% SDS PAGE
All lanes: Western blot - Anti-SOCS1 antibody (ab137384) at 1/1000 dilution
All lanes: Hep G2 whole cell lysate at 30 µg
Predicted band size: 23 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOCS1 antibody (ab137384)
Immunohistochemical analysis of paraffin-embedded A549 xenograft labelling SOCS1 with ab137384 at 1/100 dilution.
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