Rabbit Polyclonal SOCS1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human SOCS1 aa 100-200.
Images
Publications
Filter by
- Frontiers in oncology 13:12084032023Transcriptional signature of early cisplatin drug-tolerant persister cells in lung adenocarcinoma.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRodolfo Chavez-Dominguez,Dolores Aguilar-Cazares,Mario Perez-Medina,Santiago Avila-Rios,Maribel Soto-Nava,Alfonso Mendez-Tenorio,Lorenzo Islas-Vazquez,Jesus J Benito-Lopez,Miriam Galicia-Velasco,Jose S Lopez-GonzalezPubMed 37916165
- Current issues in molecular biology 45:5598-56122023SOCS1 as a Biomarker Candidate for HPV Infection and Prognosis of Head and Neck Squamous Cell Carcinomas.Applications:Unspecified applicationReactive species:Unspecified reactive speciesManli Guo,Lijie Zhang,Huihui Wang,Qiaozhen Zhou,Xinrang Zhu,Xinyu Fu,Jinlong Yang,Shanhe Liu,Dingcheng Guo,Baoping ZhangPubMed 37504269
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology 35:e213882021Microtubule-dependent mechanism of anti-inflammatory effect of SOCS1 in endothelial dysfunction and lung injury.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPratap Karki,Boyoung Cha,Chen-Ou Zhang,Yue Li,Yunbo Ke,Kamoltip Promnares,Kozo Kaibuchi,Akihiko Yoshimura,Konstantin G Birukov,Anna A BirukovaPubMed 33724556
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human SOCS1 aa 100-200. The exact immunogen used to generate this antibody is proprietary information. Database link O15524
Reactivity data
Select an application| IHC-P | WB | |
|---|---|---|
| Human | Tested | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/100.00000 - 1/1000.00000 | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
Associated Products
Select an associated product type
3 products for Alternative Product
Target data
Function
Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF) (PubMed:32499645, PubMed:33087723). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity (PubMed:9341160). Regulates IFN-gamma (IFNG)-mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11278610, PubMed:11313480).
Alternative names
SSI1, TIP3, SOCS1, Suppressor of cytokine signaling 1, SOCS-1, JAK-binding protein, STAT-induced STAT inhibitor 1, Tec-interacting protein 3, JAB, SSI-1, TIP-3
Recommended products
Rabbit Polyclonal SOCS1 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human SOCS1 aa 100-200.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human SOCS1 aa 100-200. The exact immunogen used to generate this antibody is proprietary information. Database link O15524
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
2 product images
Western blot - Anti-SOCS1 antibody (ab137384)
12% SDS PAGE
All lanes: Western blot - Anti-SOCS1 antibody (ab137384) at 1/1000 dilution
All lanes: Hep G2 whole cell lysate at 30 µg
Predicted band size: 23 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOCS1 antibody (ab137384)
Immunohistochemical analysis of paraffin-embedded A549 xenograft labelling SOCS1 with ab137384 at 1/100 dilution.
Downloads
Product protocols
- Visit the general protocols
- Visit troubleshooting
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com