AB62584

Anti-SOCS1 antibody

Name: Anti-SOCS1 antibody (ab62584) | Abcam
Brand: Abcam Limited
SKU: AB62584
Price: 670 USD
Availability: InStock

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(36 Publications)

Rabbit Polyclonal SOCS1 antibody. Suitable for WB and reacts with Human samples. Cited in 36 publications. Immunogen corresponding to Synthetic Peptide within Human SOCS1.

View Alternative Names

SSI1, TIP3, SOCS1, Suppressor of cytokine signaling 1, SOCS-1, JAK-binding protein, STAT-induced STAT inhibitor 1, Tec-interacting protein 3, JAB, SSI-1, TIP-3

2 Images

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Western blot - Anti-SOCS1 antibody (AB62584)

Lane 1:

Western blot - Anti-SOCS1 antibody (ab62584) at 1 µg/mL

Lane 2:

Western blot - Anti-SOCS1 antibody (ab62584) at 2 µg/mL

Lane 3:

Western blot - Anti-SOCS1 antibody (ab62584) at 4 µg/mL

All lanes:

Human spleen cell lysate at 15 µg

Predicted band size: 23 kDa

Observed band size: 38 kDa

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CiteAb

Western blot - Anti-SOCS1 antibody (AB62584)

SOCS1 western blot using anti-SOCS1 antibody ab62584. Publication image and figure legend from Kim, M. H., Kim, M. S., et al., 2015, PLoS One, PubMed 25849377.

ab62584 was used in this publication in western blot. This may not be the same as the application(s) guaranteed by Abcam. For a full list of applications guaranteed by Abcam for ab62584 please see the product overview.

Overexpression of SOCS1 or SOCS3 increased radioresistance of HeLa cells.SOCS1, SOCS3, or SOCS5 overexpressing HeLa cells were established using pLNCX2 retroviral vector and overexpression was confirmed by western blot analysis (A). A clonogenic assay was performed after exposure to the indicated dose of radiation in SOCS-overexpressing cells (B). Values are means ± standard deviation for triplicate wells for each dose point. Asterisk (*), statistically significant (p <0.05)

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Human SOCS1. The exact immunogen used to generate this antibody is proprietary information.

O15524

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF) (PubMed : 32499645, PubMed : 33087723). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity (PubMed : 9341160). Regulates IFN-gamma (IFNG)-mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed : 11278610, PubMed : 11313480).

See full target information SOCS1

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Publications (36)

Recent publications for all applications. Explore the full list and refine your search

Physiological research 73:37-45 PubMed38466003

2024

Protective Effects of Aspirin Supplemented With Quercetin in L-NAME-Induced Preeclampsia-Like Rats.

Applications

Unspecified application

Species

Unspecified reactive species

J Ding,S Yang,D Chen,X Shi,Y Zhang,L Song,J Zhang

Molecular neurobiology 60:5199-5213 PubMed37277682

2023

IRAK-M Ablation Promotes Status Epilepticus-Induced Neuroinflammation via Activating M1 Microglia and Impairing Excitatory Synaptic Function.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Shan Liang,Ting-Lin Qian,Yi-Fan Xiong,Xiao-Tao Liang,Yue-Wen Ding,Xiao-Yu Zhu,Yun-Lv Li,Jie-Li Zhou,Le-Yi Tan,Wei-Peng Li,Wei Xie

Experimental & molecular medicine 55:831-843 PubMed37009803

2023

LncRNA KIAA0087 suppresses the progression of osteosarcoma by mediating the SOCS1/JAK2/STAT3 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Haoli Gong,Ye Tao,Sheng Xiao,Xin Li,Ke Fang,Jie Wen,Pan He,Ming Zeng

International journal of molecular medicine 50: PubMed35795997

2022

Macrophage‑derived exosomal miRNA‑155 promotes tubular injury in ischemia‑induced acute kidney injury.

Applications

Unspecified application

Species

Unspecified reactive species

Zhijian Zhang,Hanzhi Chen,Leting Zhou,Cheng Li,Guoyuan Lu,Liang Wang

Cellular & molecular biology letters 27:36 PubMed35562668

2022

RNF7 inhibits apoptosis and sunitinib sensitivity and promotes glycolysis in renal cell carcinoma via the SOCS1/JAK/STAT3 feedback loop.

Applications

Unspecified application

Species

Unspecified reactive species

Chengwu Xiao,Wei Zhang,Meimian Hua,Huan Chen,Bin Yang,Ye Wang,Qing Yang

Science immunology 6:eabe8219 PubMed34860579

2021

In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4 T1 cell response.

Applications

Unspecified application

Species

Unspecified reactive species

Aurélien Sutra Del Galy,Silvia Menegatti,Jaime Fuentealba,Francesca Lucibello,Laetitia Perrin,Julie Helft,Aurélie Darbois,Michael Saitakis,Jimena Tosello,Derek Rookhuizen,Marc Deloger,Pierre Gestraud,Gérard Socié,Sebastian Amigorena,Olivier Lantz,Laurie Menger

PloS one 16:e0257908 PubMed34587205

2021

Transcriptome profiling reveals new insights into the roles of neuronal nitric oxide synthase on macrophage polarization towards classically activated phenotype.

Applications

Unspecified application

Species

Unspecified reactive species

Pingan Chang,Hao Gao,Quan Sun,Xiaohong He,Feifei Huang

International journal of molecular medicine 48: PubMed34368875

2021

GFI1 promotes the proliferation and migration of esophageal squamous cell carcinoma cells through the inhibition of SOCS1 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Yunlong Huang,Ran Ruan,Yanxin Fang,Kaiming Wu,Long Yao,Renquan Zhang,Wei He

Frontiers in physiology 12:709506 PubMed34434118

2021

TRIM18-Regulated STAT3 Signaling Pathway PTP1B Promotes Renal Epithelial-Mesenchymal Transition, Inflammation, and Fibrosis in Diabetic Kidney Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Qi Chen,Chan Gao,Ming Wang,Xiao Fei,Ning Zhao

Journal of breast cancer 24:330-343 PubMed34190442

2021

Long Non-Coding RNA NORAD Inhibits Breast Cancer Cell Proliferation and Metastasis by Regulating miR-155-5p/SOCS1 Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Weipeng Liu,Xin Zhou,Yuanqiang Li,Hong Jiang,Aijun Chen

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-SOCS1 antibody

Western blot - Anti-SOCS1 antibody (AB62584)

Western blot - Anti-SOCS1 antibody (AB62584)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (36)

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