Rabbit Polyclonal SOCS1 antibody. Suitable for WB and reacts with Human samples. Cited in 30 publications. Immunogen corresponding to Synthetic Peptide within Human SOCS1.
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- Molecular neurobiology 60:5199-52132023IRAK-M Ablation Promotes Status Epilepticus-Induced Neuroinflammation via Activating M1 Microglia and Impairing Excitatory Synaptic Function.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiao-Shan Liang,Ting-Lin Qian,Yi-Fan Xiong,Xiao-Tao Liang,Yue-Wen Ding,Xiao-Yu Zhu,Yun-Lv Li,Jie-Li Zhou,Le-Yi Tan,Wei-Peng Li,Wei XiePubMed 37277682
- Experimental & molecular medicine 55:831-8432023LncRNA KIAA0087 suppresses the progression of osteosarcoma by mediating the SOCS1/JAK2/STAT3 signaling pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHaoli Gong,Ye Tao,Sheng Xiao,Xin Li,Ke Fang,Jie Wen,Pan He,Ming ZengPubMed 37009803
- International journal of molecular medicine 50:2022Macrophage‑derived exosomal miRNA‑155 promotes tubular injury in ischemia‑induced acute kidney injury.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhijian Zhang,Hanzhi Chen,Leting Zhou,Cheng Li,Guoyuan Lu,Liang WangPubMed 35795997
- PloS one 16:e02579082021Transcriptome profiling reveals new insights into the roles of neuronal nitric oxide synthase on macrophage polarization towards classically activated phenotype.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPingan Chang,Hao Gao,Quan Sun,Xiaohong He,Feifei HuangPubMed 34587205
- Frontiers in physiology 12:7095062021TRIM18-Regulated STAT3 Signaling Pathway PTP1B Promotes Renal Epithelial-Mesenchymal Transition, Inflammation, and Fibrosis in Diabetic Kidney Disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQi Chen,Chan Gao,Ming Wang,Xiao Fei,Ning ZhaoPubMed 34434118
- International journal of molecular medicine 48:2021GFI1 promotes the proliferation and migration of esophageal squamous cell carcinoma cells through the inhibition of SOCS1 expression.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYunlong Huang,Ran Ruan,Yanxin Fang,Kaiming Wu,Long Yao,Renquan Zhang,Wei HePubMed 34368875
- Journal of breast cancer 24:330-3432021Long Non-Coding RNA NORAD Inhibits Breast Cancer Cell Proliferation and Metastasis by Regulating miR-155-5p/SOCS1 Axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesWeipeng Liu,Xin Zhou,Yuanqiang Li,Hong Jiang,Aijun ChenPubMed 34190442
- Neural regeneration research 16:2453-24642021SOCS1/JAK2/STAT3 axis regulates early brain injury induced by subarachnoid hemorrhage via inflammatory responses.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYang Wang,Xiang-Qian Kong,Fei Wu,Bin Xu,De-Jun Bao,Chuan-Dong Cheng,Xiang-Ping Wei,Yong-Fei Dong,Chao-Shi NiuPubMed 33907034
- Journal of neuroinflammation 18:22021Mer regulates microglial/macrophage M1/M2 polarization and alleviates neuroinflammation following traumatic brain injury.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHaijian Wu et. al.PubMed 33402181
- Molecular therapy : the journal of the American Society of Gene Therapy 29:1512-15282021Cancer-secreted exosomal miR-1468-5p promotes tumor immune escape via the immunosuppressive reprogramming of lymphatic vessels.Applications:Unspecified applicationReactive species:Unspecified reactive speciesChenfei Zhou,Wenfei Wei,Jing Ma,Yang Yang,Luojiao Liang,Yanmei Zhang,Zici Wang,Xiaojing Chen,Lei Huang,Wei Wang,Sha WuPubMed 33388421
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Synthetic Peptide within Human SOCS1. The exact immunogen used to generate this antibody is proprietary information. Database link O15524
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1.00000-2.00000 µg/mL | Notes - |
Associated Products
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3 products for Alternative Product
Target data
Function
Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF) (PubMed:32499645, PubMed:33087723). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity (PubMed:9341160). Regulates IFN-gamma (IFNG)-mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11278610, PubMed:11313480).
Alternative names
SSI1, TIP3, TIP3, SSI1, SOCS1, Suppressor of cytokine signaling 1, SOCS-1, JAK-binding protein, STAT-induced STAT inhibitor 1, Tec-interacting protein 3, JAB, SSI-1, TIP-3
Recommended products
Rabbit Polyclonal SOCS1 antibody. Suitable for WB and reacts with Human samples. Cited in 30 publications. Immunogen corresponding to Synthetic Peptide within Human SOCS1.
Key facts
- Isotype
IgG
- Host species
Rabbit
- Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituents: PBS- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Synthetic Peptide within Human SOCS1. The exact immunogen used to generate this antibody is proprietary information. Database link O15524
- Purification technique
Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
Blue Ice
- Appropriate short-term storage duration
1-2 weeks
- Appropriate short-term storage conditions
+4°C
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-SOCS1 antibody (ab62584)
Lane 1: Western blot - Anti-SOCS1 antibody (ab62584) at 1 µg/mL
Lane 2: Western blot - Anti-SOCS1 antibody (ab62584) at 2 µg/mL
Lane 3: Western blot - Anti-SOCS1 antibody (ab62584) at 4 µg/mL
All lanes: Human spleen cell lysate at 15 µg
Predicted band size: 23 kDa
Observed band size: 38 kDa
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