Goat Polyclonal SOCS1 antibody. Suitable for IHC-P, ICC, Flow Cyt, ICC/IF, Flow Cyt (Intra) and reacts with Mouse, Human, Rat, Pig samples. Cited in 38 publications. Immunogen corresponding to Synthetic Peptide within Human SOCS1 aa 150 to C-terminus.
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Publications
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- World journal of gastroenterology 29:5226-52392023Curcumin alleviated dextran sulfate sodium-induced colitis by recovering memory Th/Tfh subset balance.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLin-Xin Zheng,Kai-En Guo,Jia-Qi Huang,Miao-Hua Liu,Bai-Ling Deng,Duan-Yong Liu,Bu-Gao Zhou,Wen Zhou,You-Bao Zhong,Hai-Mei ZhaoPubMed 37901446
- International journal of molecular sciences 24:2023Effects of Tofacitinib on Muscle Remodeling in Experimental Rheumatoid Sarcopenia.Applications:Unspecified applicationReactive species:Unspecified reactive speciesIsmael Bermejo-Álvarez,Sandra Pérez-Baos,Paula Gratal,Juan Pablo Medina,Raquel Largo,Gabriel Herrero-Beaumont,Aránzazu MedieroPubMed 37685986
- Experimental & molecular medicine 55:831-8432023LncRNA KIAA0087 suppresses the progression of osteosarcoma by mediating the SOCS1/JAK2/STAT3 signaling pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHaoli Gong,Ye Tao,Sheng Xiao,Xin Li,Ke Fang,Jie Wen,Pan He,Ming ZengPubMed 37009803
- International journal of immunopathology and pharmacology 36:39463202211330182022Syk promotes phagocytosis by inducing reactive oxygen species generation and suppressing SOCS1 in macrophage-mediated inflammatory responses.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYoung-Su Yi,Han Gyung Kim,Ji Hye Kim,Woo Seok Yang,Eunji Kim,Jae Gwang Park,Nur Aziz,Narayanan Parameswaran,Jae Youl ChoPubMed 36214175
- Frontiers in immunology 13:9340842022Effect of Polysaccharide on M1 Polarization Induced by Autophagy Degradation of SOCS1/2 Proteins in 3D4/21 Cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesLiping Li,Xufang Chen,Meiyun Lv,Ziqiang Cheng,Fang Liu,Ying Wang,Aiqin Zhou,Jianzhu Liu,Xiaona ZhaoPubMed 35844489
- eLife 11:2022Macrophage inflammation resolution requires CPEB4-directed offsetting of mRNA degradation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesClara Suñer,Annarita Sibilio,Judit Martín,Chiara Lara Castellazzi,Oscar Reina,Ivan Dotu,Adrià Caballé,Elisa Rivas,Vittorio Calderone,Juana Díez,Angel R Nebreda,Raúl MéndezPubMed 35442882
- Journal of microbiology (Seoul, Korea) 60:402-4102022Down-regulation of microRNA-155 suppressed Candida albicans induced acute lung injury by activating SOCS1 and inhibiting inflammation response.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaohua Li,Yuanzhong Gong,Xin Lin,Qiong Lin,Jianxiong Luo,Tianxing Yu,Junping Xu,Lifang Chen,Liyu Xu,Ying HuPubMed 35157222
- BMC nephrology 22:4172021A novel de novo truncating TRIM8 variant associated with childhood-onset focal segmental glomerulosclerosis without epileptic encephalopathy: a case report.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYoko Shirai,Kenichiro Miura,Naoto Kaneko,Kiyonobu Ishizuka,Amane Endo,Taeko Hashimoto,Shoichiro Kanda,Yutaka Harita,Motoshi HattoriPubMed 34930159
- American journal of translational research 13:12395-124092021PIAS3/SOCS1-STAT3 axis responses to oxidative stress in hepatocellular cancer cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHonghua Sun,Yanglong Li,Xianglan Quan,Ning Chen,Xinglin Jin,Wenbiao Jin,Yongmin Jin,Xionghu ShenPubMed 34956461
- BioMed research international 2021:93118552021SOCS1 Mediates Berberine-Induced Amelioration of Microglial Activated States in N9 Microglia Exposed to Amyloid.Applications:Unspecified applicationReactive species:Unspecified reactive speciesQi Guo,Chen Wang,Xiaorong Xue,Bin Hu,He BaoPubMed 34778460
Key facts
- Isotype
IgG
- Host species
Goat
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, 0.5% Tris- Form
Liquid
- Clonality
Polyclonal
Immunogen
- Synthetic Peptide within Human SOCS1 aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link O15524
Reactivity data
Select an application| IHC-P | ICC | Flow Cyt | ICC/IF | Flow Cyt (Intra) | |
|---|---|---|---|---|---|
| Human | Tested | Tested | Tested | Expected | Tested |
| Mouse | Tested | Expected | Expected | Expected | Expected |
| Rat | Predicted | Predicted | Predicted | Expected | Predicted |
| Cow | Predicted | Predicted | Predicted | Predicted | Predicted |
| Dog | Predicted | Predicted | Predicted | Predicted | Predicted |
| Pig | Predicted | Predicted | Predicted | Expected | Predicted |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 2.00000-3.00000 µg/mL | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Species Human | Dilution info 2.00000-3.00000 µg/mL | Notes Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cow, Dog, Pig, Rat | Dilution info - | Notes - |
ICC
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cow, Dog, Pig, Rat | Dilution info - | Notes - |
Flow Cyt
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes ab37373 - Goat polyclonal IgG, is suitable for use as an isotype control with this antibody. |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cow, Dog, Pig, Rat | Dilution info - | Notes - |
ICC/IF
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat, Pig, Human | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cow, Dog | Dilution info - | Notes - |
Flow Cyt (Intra)
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cow, Dog, Pig, Rat | Dilution info - | Notes - |
Associated Products
Select an associated product type
3 products for Alternative Product
Target data
Function
Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF) (PubMed:32499645, PubMed:33087723). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity (PubMed:9341160). Regulates IFN-gamma (IFNG)-mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11278610, PubMed:11313480).
Alternative names
SSI1, TIP3, TIP3, SSI1, SOCS1, Suppressor of cytokine signaling 1, SOCS-1, JAK-binding protein, STAT-induced STAT inhibitor 1, Tec-interacting protein 3, JAB, SSI-1, TIP-3
Recommended products
Goat Polyclonal SOCS1 antibody. Suitable for IHC-P, ICC, Flow Cyt, ICC/IF, Flow Cyt (Intra) and reacts with Mouse, Human, Rat, Pig samples. Cited in 38 publications. Immunogen corresponding to Synthetic Peptide within Human SOCS1 aa 150 to C-terminus.
Key facts
- Isotype
IgG
- Host species
Goat
- Storage buffer
pH: 7.3
Preservative: 0.02% Sodium azide
Constituents: 0.5% BSA, 0.5% Tris- Form
Liquid
- Clonality
Polyclonal
- Immunogen
- Synthetic Peptide within Human SOCS1 aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information. Database link O15524
- Purification technique
Affinity purification Immunogen
- Concentration
- Purification notes
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Storage
- Shipped at conditions
Blue Ice
- Appropriate long-term storage conditions
-20°C
- Aliquoting information
Upon delivery aliquot
- Storage information
Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
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4 product images
Immunocytochemistry - Anti-SOCS1 antibody (ab9870)
Immunofluorescence analysis of paraformaldehyde fixed MCF7 cells, permeabilized with 0.15% Triton. Primary incubation with ab9870 (10 μg/ml) followed by Alexa Fluor 488 secondary antibody (2 μg/ml), showing cytoplasmic and nuclear staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 μg/ml) followed by Alexa Fluor 488 secondary antibody (2 μg/ml).
Flow Cytometry (Intracellular) - Anti-SOCS1 antibody (ab9870)
Flow cytometric analysis of HEK293 cells with ab9870 (blue line), permeabilized with 0.5% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (1ug/ml). IgG control: Unimmunized goat IgG (black line) followed by Alexa Fluor 488 secondary antibody.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOCS1 antibody (ab9870)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) staining of paraffin embedded Human Kidney with ab9870 (8 μg/ml). Heat induced antigen retrieval with citrate buffer pH 6, HRP-staining.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SOCS1 antibody (ab9870)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) staining of paraffin embedded Mouse Kidney with ab9870 (8 μg/ml). Heat induced antigen retrieval with citrate buffer pH 6, HRP-staining.
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